UBE2B Gene

HGNC Family	Ubiquitin-conjugating enzymes E2 (UBE2)
Name	ubiquitin-conjugating enzyme E2B
Description	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2B, a ubiquitin‐conjugating enzyme also known as human RAD6B, plays a central role in maintaining genomic integrity by promoting DNA repair. It functions in postreplication repair and translesion synthesis by partnering with E3 ligases such as RAD18 and MDM2 to ubiquitinate key substrates—including histone proteins, p53, and heterochromatin protein 1α—to facilitate lesion bypass and homologous recombination repair. In oral cancer cells, for instance, microRNA‐mediated downregulation of UBE2B contributes to tumorigenesis, illustrating its importance in cellular responses to DNA damage and stress."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUBE2B is also critical for normal spermatogenesis. Animal studies reveal that loss of UBE2B function causes structural abnormalities in sperm—including disorganization of the fibrous sheath and impaired mitochondrial sheath formation—that lead to male infertility. In human studies, genetic variations and post‐transcriptional defects in the UBE2B gene have been significantly associated with conditions such as oligozoospermia, underscoring its indispensable role in sperm development and function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe catalytic activity of UBE2B is tightly regulated by both posttranslational modifications and its intrinsic structural features. Phosphorylation at key residues such as Ser120 has been shown to modulate its ubiquitin‐conjugating efficiency—altering substrate ubiquitination profiles—and mutations in conserved regions like helix‐3 (for example, substitutions at Ala126) disrupt its catalytic pocket organization, thereby impairing the charging and discharging steps essential for ubiquitin transfer. These regulatory mechanisms ensure that UBE2B functions with precision in context‐dependent cellular pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of cancer, aberrant UBE2B activity—often manifesting as its overexpression—contributes to chemoresistance and tumor progression. In aggressive cancers such as triple negative breast cancer, ovarian cancer, and melanoma, UBE2B promotes error‐prone DNA repair and supports oncogenic signaling pathways by modulating the stability and activity of proteins including β‐catenin and other transcriptional regulators. The therapeutic targeting of UBE2B, using selective small‐molecule inhibitors, has shown promise in sensitizing cancer cells to platinum-based chemotherapies and in impairing tumor growth, highlighting its potential as a novel intervention point in cancer treatment."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Alex Lyakhovich, Malathy P V Shekhar "}, {"type": "b", "children": [{"type": "t", "text": "RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1207449"}], "href": "https://doi.org/10.1038/sj.onc.1207449"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14981545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14981545"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Su Chen, Chen Wang, Luxi Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAD6 promotes homologous recombination repair by activating the autophagy-mediated degradation of heterochromatin protein HP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01044-14"}], "href": "https://doi.org/10.1128/MCB.01044-14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25384975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25384975"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chao-Min Cheng, Shine-Gwo Shiah, Chien-Chang Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of miR-455-5p by the TGF-β-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4752"}], "href": "https://doi.org/10.1002/path.4752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27235675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27235675"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Matthew A Sanders, Brittany Haynes, Pratima Nangia-Makker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M117.792192"}], "href": "https://doi.org/10.1074/jbc.M117.792192"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28490629"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28490629"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ivan Huang, Benjamin R Emery, Greg L Christensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel UBE2B-associated polymorphisms in an azoospermic/oligozoospermic population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian J Androl (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1745-7262.2008.00386.x"}], "href": "https://doi.org/10.1111/j.1745-7262.2008.00386.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18385908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18385908"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Viswanadhapalli Suryavathi, Arun Khattri, Kaliappan Gopal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel variants in UBE2B gene and idiopathic male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Androl (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2164/jandrol.107.004580"}], "href": "https://doi.org/10.2164/jandrol.107.004580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18497339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18497339"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Y Hu, W Wen, J-G Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2012.September.12.2"}], "href": "https://doi.org/10.4238/2012.September.12.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23079972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23079972"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alexander N Yatsenko, Andrew P Georgiadis, Lata J Murthy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gat008"}], "href": "https://doi.org/10.1093/molehr/gat008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23378580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23378580"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lisha Mou, Qiang Zhang, Ruiying Diao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-015-0074-4"}], "href": "https://doi.org/10.1186/s12958-015-0074-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26223869"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26223869"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Brajesh Kumar, Kimberly G Lecompte, Jennifer M Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ser(120) of Ubc2/Rad6 regulates ubiquitin-dependent N-end rule targeting by E3{alpha}/Ubr1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.169136"}], "href": "https://doi.org/10.1074/jbc.M110.169136"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21041297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21041297"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gonghua Hu, Zhixiong Zhuang, Jianping Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Effect of hydroquinone on the expression of ubiquitin-conjugating enzyme Rad6B in human L-02 hepatic cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Wei Sheng Yan Jiu (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19548583"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19548583"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Prakash K Shukla, Dhiraj Sinha, Andrew M Leng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations of Rad6 E2 ubiquitin-conjugating enzymes at alanine-126 in helix-3 affect ubiquitination activity and decrease enzyme stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.102524"}], "href": "https://doi.org/10.1016/j.jbc.2022.102524"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36162503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36162503"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Brittany Haynes, Ambikai Gajan, Pratima Nangia-Makker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAD6B is a major mediator of triple negative breast cancer cisplatin resistance: Regulation of translesion synthesis/Fanconi anemia crosstalk and BRCA1 independence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2019.165561"}], "href": "https://doi.org/10.1016/j.bbadis.2019.165561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31639439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31639439"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ambikai Gajan, Carly E Martin, Seongho Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative Splicing of RAD6B and Not RAD6A is Selectively Increased in Melanoma: Identification and Functional Characterization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells8111375"}], "href": "https://doi.org/10.3390/cells8111375"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31683936"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31683936"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xi Zeng, Wen Zheng, Yuting Sheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2B promotes ovarian cancer growth via promoting RAD18 mediated ZMYM2 monoubiquitination and stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2048991"}], "href": "https://doi.org/10.1080/21655979.2022.2048991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35313791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35313791"}]}]}]}
Synonyms	E2-17KDA, HHR6B, HR6B, RAD6B
Proteins	UBE2B_HUMAN
NCBI Gene ID	7320
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE2B has 8,031 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for UBE2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE2B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE2B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBE2B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE2B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UBE2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBE2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE2B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE2B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UBE2B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE2B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE2B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE2B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with UBE2B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with UBE2B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBE2B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing UBE2B from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of UBE2B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.