UBE2K Gene

HGNC Family	Ubiquitin-conjugating enzymes E2 (UBE2)
Name	ubiquitin-conjugating enzyme E2K
Description	The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2K, also known as E2‐25K or Hip2, is a multifunctional ubiquitin‐conjugating enzyme that plays critical roles in neurodegenerative disorders by modulating protein aggregation and toxicity. In models of polyglutamine diseases such as Huntington’s disease, UBE2K interacts directly with aberrant proteins to promote their ubiquitination and inclusion formation, a process that may influence neuronal cell death. In addition, UBE2K binds non‐canonical ubiquitin species (e.g. UBB(+1)) to drive the accumulation of neurotoxic polyubiquitin chains, and altered interactions with partners such as the E3 ligase BRCA1 have been implicated in Alzheimer’s and Parkinson’s pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, UBE2K is distinguished by its ability to synthesize Lys48‐linked polyubiquitin chains—the canonical signal for proteasomal degradation. Structural and biochemical studies have revealed that UBE2K functions as a monomer via its catalytic ubiquitin‐conjugating (UBC) domain, with its auxiliary C‐terminal ubiquitin‐associated (UBA) domain enhancing processivity and chain‐linkage specificity. UBE2K is capable of driving polyubiquitination even in the absence of an E3 ligase, as shown in endoplasmic reticulum–associated degradation (ERAD) processes and in the regulation of histone H3 levels in stem cells. Furthermore, detailed analyses of its active site gate dynamics and inhibition by natural compounds such as vitexin have provided significant insights into the precise control of its catalytic activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in protein quality control and aggregate handling, UBE2K exerts significant influence over cell cycle regulation and apoptosis. By targeting key regulators such as p53 and proapoptotic factors like Smac/DIABLO for ubiquitination and subsequent degradation, UBE2K helps to modulate DNA damage responses and the transition through cell cycle checkpoints. These actions contribute to the overcoming of radiation‐ or UV–induced cell cycle arrest, while aberrant elevation of UBE2K has been associated with oncogenic processes in disorders such as hepatocellular carcinoma and glioma through the upregulation of proliferative drivers like c-Myc. Moreover, increased peripheral expression of UBE2K in schizophrenia further supports its broader involvement in disease‐related ubiquitin–proteasome system dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Remko de Pril, David F Fischer, Raymund A C Roos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2006.09.006"}], "href": "https://doi.org/10.1016/j.mcn.2006.09.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17092742"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17092742"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sunggeon Ko, Gil Bu Kang, Sung Min Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis of E2-25K/UBB+1 interaction leading to proteasome inhibition and neurotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.145219"}], "href": "https://doi.org/10.1074/jbc.M110.145219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20826778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20826778"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mehar Sahu, Neetu Rani, Pravir Kumar "}, {"type": "b", "children": [{"type": "t", "text": "Simulation and Computational Study of RING Domain Mutants of BRCA1 and Ube2k in AD/PD Pathophysiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biotechnol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12033-023-01006-4"}], "href": "https://doi.org/10.1007/s12033-023-01006-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38172369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38172369"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Adam J Middleton, Catherine L Day "}, {"type": "b", "children": [{"type": "t", "text": "The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep16793"}], "href": "https://doi.org/10.1038/srep16793"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26592444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26592444"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dennis Flierman, Catherine S Coleman, Cecile M Pickart, et al. "}, {"type": "b", "children": [{"type": "t", "text": "E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0605215103"}], "href": "https://doi.org/10.1073/pnas.0605215103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16868077"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16868077"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Randall C Wilson, Stephen P Edmondson, Justin W Flatt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E2-25K ubiquitin-associated (UBA) domain aids in polyubiquitin chain synthesis and linkage specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2011.01.089"}], "href": "https://doi.org/10.1016/j.bbrc.2011.01.089"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21281599"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21281599"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Azra Fatima, Dilber Irmak, Alireza Noormohammadi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-020-0984-3"}], "href": "https://doi.org/10.1038/s42003-020-0984-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32451438"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32451438"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jung-Gyu Lee, Hyung-Seop Youn, Jung Youn Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of the Ube2K/E2-25K and K48-linked di-ubiquitin complex provides structural insight into the mechanism of K48-specific ubiquitin chain synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.10.067"}], "href": "https://doi.org/10.1016/j.bbrc.2018.10.067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30336976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30336976"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Manoj K Rout, Brian L Lee, Aiyang Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Active Site Gate Dynamics Modulate the Catalytic Activity of the Ubiquitination Enzyme E2-25K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-25476-8"}], "href": "https://doi.org/10.1038/s41598-018-25476-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29725124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29725124"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kimberli M Helms, Randall C Wilson, Ifedayo V Ogungbe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vitexin inhibits polyubiquitin synthesis by the ubiquitin-conjugating enzyme E2-25K."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Prod Commun (2011)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22164771"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22164771"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hannah Meiklejohn, Md Shaki Mostaid, Sandra Luza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatr Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpsychires.2019.03.005"}], "href": "https://doi.org/10.1016/j.jpsychires.2019.03.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30901725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30901725"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yoonhee Bae, Song Hwa Jung, Goo-Young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hip2 ubiquitin-conjugating enzyme overcomes radiation-induced G2/M arrest."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2013.07.023"}], "href": "https://doi.org/10.1016/j.bbamcr.2013.07.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23933584"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23933584"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Nan Hee Hong, Yeong Jin Tak, Hyangshuk Rhim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hip2 ubiquitin-conjugating enzyme has a role in UV-induced G1/S arrest and re-entry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13258-018-0747-4"}], "href": "https://doi.org/10.1007/s13258-018-0747-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30264212"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30264212"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yoonhee Bae, Chang Won Kho, Soo Young Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hip2 interacts with and destabilizes Smac/DIABLO."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.06.016"}], "href": "https://doi.org/10.1016/j.bbrc.2010.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20537984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20537984"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Xiangxiang Lei, Xiaoge Hu, Qiliang Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2K promotes the malignant progression of hepatocellular carcinoma by regulating c-Myc."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.11.046"}], "href": "https://doi.org/10.1016/j.bbrc.2022.11.046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36481361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36481361"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Guangxiong Ouyang, Wen Fu, Jinhui Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced UBE2K promotes the malignant progression of HCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.154422"}], "href": "https://doi.org/10.1016/j.prp.2023.154422"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37003132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37003132"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhen Xin, Kristian Holgersson, Pengcheng Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing UBE2K inhibits the growth of glioma cells by inducing the autophagy-related apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23758"}], "href": "https://doi.org/10.1002/jbt.23758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38963134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38963134"}]}]}]}
Synonyms	LIG, HYPG, HIP2, UBC1, E2-25K
Proteins	UBE2K_HUMAN
NCBI Gene ID	3093
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE2K has 7,405 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for UBE2K from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE2K Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2K gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2K gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE2K gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE2K gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE2K gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2K gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2K gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2K gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2K gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2K gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2K gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE2K protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2K gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE2K gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE2K gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE2K protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UBE2K protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UBE2K protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBE2K protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE2K protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2K gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE2K gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE2K gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE2K gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE2K gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE2K gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE2K gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE2K gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE2K gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE2K gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2K gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE2K gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE2K from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2K gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBE2K gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing UBE2K from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of UBE2K gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of UBE2K gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of UBE2K gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE2K gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.