{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE2S is a critical ubiquitin‐conjugating enzyme that functions predominantly in mitotic regulation. It collaborates with the anaphase‐promoting complex/cyclosome (APC/C) by elongating K11‐linked ubiquitin chains on pre‐modified substrates, a process initiated by enzymes such as UbcH10. This chain elongation enhances substrate recognition by the proteasome and ensures timely degradation of key cell‐cycle regulators to drive mitotic exit. Structural and mechanistic studies further reveal that UBE2S achieves its linkage specificity via unique noncovalent interactions with donor ubiquitin, thereby providing a substrate‐assisted catalytic mechanism necessary for robust APC/C activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its essential role in regulating mitosis, UBE2S modulates several key signaling pathways that respond to cellular stress and dictate cell fate. At sites of DNA damage, it cooperates with specific E3 ligases to assemble Lys11‐linked ubiquitin conjugates on chromatin, thereby contributing to transcriptional silencing and efficient repair. UBE2S also targets β‐catenin for K11‐linked ubiquitination, leading to its stabilization and the subsequent activation of canonical Wnt/β‐catenin signaling—a process that influences stem cell differentiation and tumor progression. Moreover, UBE2S attenuates innate immune responses by interacting with TBK1 and recruiting deubiquitinating enzymes to remove activating ubiquitin chains, thus serving as a negative regulator of type I interferon production."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant overexpression and dysregulation of UBE2S have been documented in a broad spectrum of human cancers, where its oncogenic activities correlate with aggressive disease and poor clinical outcomes. Elevated levels of UBE2S have been associated with enhanced cellular proliferation, migration, and invasion in hepatocellular carcinoma, breast cancer, renal, esophageal, endometrial, ovarian, lung, melanoma, bladder, and pan‐cancer analyses. Mechanistically, UBE2S promotes tumorigenesis by facilitating the degradation of key tumor suppressors such as p27 and p53, while concurrently stabilizing oncogenic drivers like β‐catenin. Its ability to modulate additional pathways—including mTOR and NF‐κB signaling—underscores its multifaceted role in tumor progression and highlights its potential as a therapeutic target; indeed, pharmacological inhibitors directed against UBE2S have shown promising preclinical efficacy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther fine‐tuning of UBE2S activity is achieved through intricate posttranslational modifications that impact its conformation and enzymatic cycling. Autoubiquitination events and dimerization regulate the reloading of ubiquitin onto UBE2S, thereby modulating its activity during the cell cycle. In the context of viral infection, UBE2S exerts antiviral effects by mediating the Lys11‐linked degradation of viral proteins such as the hepatitis C virus NS5A, an activity that underscores its broader role in maintaining cellular protein homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mathew J Garnett, Jörg Mansfeld, Colin Godwin, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Identification of a physiological E2 module for the human anaphase-promoting complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0907887106"}], "href": "https://doi.org/10.1073/pnas.0907887106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19822757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19822757"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tao Wu, Yifat Merbl, Ying Huo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0912802107"}], "href": "https://doi.org/10.1073/pnas.0912802107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20080579"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20080579"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Katherine E Wickliffe, Sonja Lorenz, David E Wemmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.01.035"}], "href": "https://doi.org/10.1016/j.cell.2011.01.035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21376237"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21376237"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hermann-Josef Meyer, Michael Rape "}, {"type": "b", "children": [{"type": "t", "text": "Enhanced protein degradation by branched ubiquitin chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.03.037"}], "href": "https://doi.org/10.1016/j.cell.2014.03.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24813613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24813613"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Thomas Wild, Marie Sofie Yoo Larsen, Takeo Narita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2016.01.060"}], "href": "https://doi.org/10.1016/j.celrep.2016.01.060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26904940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26904940"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Peng Kuang, Mingjia Tan, Weihua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep37441"}], "href": "https://doi.org/10.1038/srep37441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27910872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27910872"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Atanu Paul, Bin Wang "}, {"type": "b", "children": [{"type": "t", "text": "RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2017.04.013"}], "href": "https://doi.org/10.1016/j.molcel.2017.04.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28525740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28525740"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Zhaoyan Li, Yan Wang, Yadan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-018-0451-y"}], "href": "https://doi.org/10.1038/s41419-018-0451-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29674637"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29674637"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yanan Qin, Jiang Du, Chuifeng Fan "}, {"type": "b", "children": [{"type": "t", "text": "Ube2S regulates Wnt/β-catenin signaling and promotes the progression of non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Med Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijms.40243"}], "href": "https://doi.org/10.7150/ijms.40243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32038111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32038111"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Li Huang, Hongyang Liu, Kunli Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.108044"}], "href": "https://doi.org/10.1016/j.celrep.2020.108044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32814047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32814047"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jung Hwa Lim, Cho-Rok Jung, Chan-Hee Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Egr-1 and serum response factor are involved in growth factors- and serum-mediated induction of E2-EPF UCP expression that regulates the VHL-HIF pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.21914"}], "href": "https://doi.org/10.1002/jcb.21914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18780286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18780286"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Miao-Fen Chen, Kuan-Der Lee, Ming-Shian Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The predictive role of E2-EPF ubiquitin carrier protein in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Med (Berl) (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00109-008-0430-3"}], "href": "https://doi.org/10.1007/s00109-008-0430-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19083192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19083192"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Frederik C Roos, Andrew J Evans, Walburgis Brenner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of E2-EPF ubiquitin carrier protein in papillary renal cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajpath.2010.10.033"}], "href": "https://doi.org/10.1016/j.ajpath.2010.10.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21281817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21281817"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jing Liang, Hirotaka Nishi, Mei-Lu Bian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin-conjugating enzyme E2-EPF is overexpressed in cervical cancer and associates with tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.1949"}], "href": "https://doi.org/10.3892/or.2012.1949"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22895574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22895574"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Akter Khondker Ayesha, Toshinori Hyodo, Eri Asano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S is associated with malignant characteristics of breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-3863-7"}], "href": "https://doi.org/10.1007/s13277-015-3863-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26245992"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26245992"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ying-Hua Pan, Mei Yang, Li-Ping Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S enhances the ubiquitination of p53 and exerts oncogenic activities in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.06.093"}], "href": "https://doi.org/10.1016/j.bbrc.2018.06.093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29928880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29928880"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Meifang Lin, Ting Lei, Ju Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S mediates tumor progression via SOX6/β-Catenin signaling in endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2019.01.014"}], "href": "https://doi.org/10.1016/j.biocel.2019.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30690078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30690078"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ping Wang, Yong Li, Yangyang Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive Investigation into the Role of Ubiquitin-Conjugating Enzyme E2S in Melanoma Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2020.05.113"}], "href": "https://doi.org/10.1016/j.jid.2020.05.113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32603752"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32603752"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Anna K L Liess, Alena Kucerova, Kristian Schweimer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dimerization regulates the human APC/C-associated ubiquitin-conjugating enzyme UBE2S."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.aba8208"}], "href": "https://doi.org/10.1126/scisignal.aba8208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33082289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33082289"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Ren-Yu Zhang, Ze-Kun Liu, Ding Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Signal Transduct Target Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41392-020-00432-z"}], "href": "https://doi.org/10.1038/s41392-020-00432-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33589597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33589597"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hao Tang, Tong Fang, Meng Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S exerts oncogenic activities in urinary bladder cancer by ubiquitinating TSC1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2021.08.057"}], "href": "https://doi.org/10.1016/j.bbrc.2021.08.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34520980"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34520980"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Wenjing Hu, Min Li, Youguo Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S promotes the progression and Olaparib resistance of ovarian cancer through Wnt/β-catenin signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Ovarian Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13048-021-00877-y"}], "href": "https://doi.org/10.1186/s13048-021-00877-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34535173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34535173"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Jhih-Yun Ho, Hsin-Ying Lu, Hsing-Hsien Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S activates NF-κB signaling by binding with IκBα and promotes metastasis of lung adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-021-00639-4"}], "href": "https://doi.org/10.1007/s13402-021-00639-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34582005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34582005"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shengmeng Peng, Xu Chen, Chaoyun Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S as a novel ubiquitinated regulator of p16 and β-catenin to promote bone metastasis of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/ijbs.72629"}], "href": "https://doi.org/10.7150/ijbs.72629"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35637955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35637955"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Kanghua Xiao, Shengmeng Peng, Junlin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-023-05938-2"}], "href": "https://doi.org/10.1038/s41419-023-05938-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37422473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37422473"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Haodi Yue, Jialin Wang, Siyu Hou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "As a potential predictor of pan-cancer, "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "UBE2S"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " is related to tumor-associated macrophage infiltration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Future Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/fon-2023-0086"}], "href": "https://doi.org/10.2217/fon-2023-0086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37791471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37791471"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "H Chen, Z Li, M Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[High expression of UBE2S promotes progression of hepatocellular carcinoma by increasing cancer cell stemness]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12122/j.issn.1673-4254.2024.03.06"}], "href": "https://doi.org/10.12122/j.issn.1673-4254.2024.03.06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38597436"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38597436"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Hang T Pham, Tram T T Nguyen, Lap P Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01240-18"}], "href": "https://doi.org/10.1128/JVI.01240-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30381483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30381483"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Anna K L Liess, Alena Kucerova, Kristian Schweimer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2019.05.008"}], "href": "https://doi.org/10.1016/j.str.2019.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31230944"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31230944"}]}]}]}