UBE2Z Gene

HGNC Family	Ubiquitin-conjugating enzymes E2 (UBE2)
Name	ubiquitin-conjugating enzyme E2Z
Description	This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nProtein ubiquitination is a fundamental post‐translational modification that regulates diverse cellular functions through an E1–E2–E3 enzymatic cascade. In this complex system, E2 ubiquitin–conjugating enzymes transfer the activated ubiquitin from E1 enzymes to substrates via E3 ligases. Although one study highlighted the functional divergence of E1 enzymes and their specific charging of distinct E2 partners (including the UBA6‐specific E2, USE1, in lung cancer tumorigenesis)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", research specifically addressing UBE2Z has demonstrated that this putative ubiquitin–conjugating enzyme is encoded by a gene that produces a 246–amino acid protein, is mapped to human chromosome 17q21.32, and exhibits a broad tissue expression profile with notable presence in the placenta, pancreas, spleen, and testis. Its subcellular localization in both the nucleus and cytoplasm suggests potential roles in diverse cellular contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn hepatocellular carcinoma (HCC), UBE2Z is significantly overexpressed relative to normal liver tissue, and high levels of UBE2Z correlate with advanced tumor stage, vascular invasion, and poorer patient survival. Functional studies in HCC cell lines have shown that silencing UBE2Z leads to reduced proliferation, migration, and invasion, likely by suppressing matrix metalloproteinases (MMP2 and MMP9) and modulating key signaling cascades such as ERK and STAT3 pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in cancer, UBE2Z has garnered attention for its genetic associations with cardiometabolic disorders. Several studies report that the UBE2Z single nucleotide polymorphism rs46522 is linked to an increased risk of coronary artery disease (CAD) and myocardial infarction (MI) across diverse populations, including Chinese, Iranian, and Mexican cohorts. Moreover, regulatory interplay, as suggested by its interaction with transcription factor TCF7L2, points to a contributory role in type 2 diabetes mellitus pathogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianping Jin, Xue Li, Steven P Gygi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05902"}], "href": "https://doi.org/10.1038/nature05902"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17597759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17597759"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Seong-Jin Kim, Tae Hyeong Lee, Sang Hee Nam, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Uba6-Specific-E2 (USE1) With Lung Tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djw224"}], "href": "https://doi.org/10.1093/jnci/djw224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28376205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28376205"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xing Gu, Feng Zhao, Mei Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Rep (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11033-006-9033-7"}], "href": "https://doi.org/10.1007/s11033-006-9033-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17160626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17160626"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaokang Shi, Bin Wang, Xiaoyan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of ubiquitin-conjugating enzyme E2Z is associated with human hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.11.170"}], "href": "https://doi.org/10.1016/j.bbrc.2019.11.170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31831168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31831168"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Difei Lu, Jia Huang, Xiaowei Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rs46522 in the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with the Risk of Coronary Artery Disease in Individuals of Chinese Han Population with Type 2 Diabetes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2017/4501794"}], "href": "https://doi.org/10.1155/2017/4501794"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28840129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28840129"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "M Bastami, S M Ghaderian, M D Omrani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol (Noisy-le-grand) (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26602883"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26602883"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ali Mohammad Foroughmand, Sana Shafidelpour, Merhrnoosh Zakerkish, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between the UBE2Z rs46522 and TCF7L2 rs7903146 polymorphisms with type 2 diabetes in south western Iran."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Afr Health Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4314/ahs.v19i3.24"}], "href": "https://doi.org/10.4314/ahs.v19i3.24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32127821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32127821"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "José Manuel Rodríguez-Pérez, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The rs46522 Polymorphism of the Ubiquitin-Conjugating Enzyme E2Z Gene Is Associated with Abnormal Metabolic Parameters in Patients with Myocardial Infarction: The Genetics of Atherosclerosis Disease Mexican Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2020.5477"}], "href": "https://doi.org/10.1089/dna.2020.5477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32392439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32392439"}]}]}]}
Synonyms	USE1, HOYS7
Proteins	UBE2Z_HUMAN
NCBI Gene ID	65264
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE2Z has 6,730 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for UBE2Z from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE2Z Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Z gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Z gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE2Z gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE2Z gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE2Z gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE2Z gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2Z gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2Z gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE2Z gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2Z gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE2Z gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE2Z protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBE2Z gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2Z gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE2Z gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE2Z gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UBE2Z protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE2Z gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE2Z protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UBE2Z protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UBE2Z protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE2Z protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE2Z gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE2Z gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE2Z gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE2Z gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with UBE2Z gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UBE2Z protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE2Z gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with UBE2Z gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UBE2Z gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE2Z gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE2Z gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE2Z gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE2Z gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE2Z gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE2Z gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE2Z gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE2Z from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with UBE2Z gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.