UBE3B Gene

Name	ubiquitin protein ligase E3B
Description	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE3B is a HECT‐domain E3 ubiquitin ligase that plays a critical role in cellular protein homeostasis and neurodevelopment. Molecular studies first characterized the full‐length cDNA of UBE3B and uncovered an alternative splicing mechanism that generates both a functional isoform—with a complete HECT domain essential for ubiquitin transfer—and a truncated, likely inactive variant (as observed in."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although not implicated in the genetic studies of complex traits such as alcohol dependence"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", subsequent investigations have firmly associated biallelic UBE3B mutations with a rare developmental disorder previously referred to as Kaufman oculocerebrofacial syndrome (KOS) or blepharophimosis-ptosis-intellectual disability syndrome. A number of independent clinical studies reported that patients carrying recessive mutations in UBE3B display a constellation of features—including microcephaly, growth retardation, facial dysmorphisms, congenital anomalies, low cholesterol levels and severe intellectual disability—which has expanded the phenotypic spectrum of this disorder."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in neurodevelopment, UBE3B is emerging as a key regulator of intracellular organelle function and cellular signaling. Functional studies have demonstrated that UBE3B associates with mitochondria, where its proper ubiquitin ligase activity is essential for maintaining mitochondrial morphology, volume, and overall cellular proliferation. Notably, UBE3B activity is modulated by calmodulin binding via an N-terminal IQ motif, with calcium fluctuations disrupting this interaction and consequently enhancing its ubiquitination activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Moreover, UBE3B contributes to oncogenic pathways. One study revealed that UBE3B mediates the ubiquitination and turnover of MYC, a central transcription factor in lymphoma, an activity counteracted by TRIB3 that ultimately stabilizes MYC and promotes tumor cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In a separate oncological context, UBE3B was identified as the E3 ligase responsible for K63-linked polyubiquitination of hypoxia-inducible factor 2α (HIF-2α), a modification that prevents its degradation and supports breast cancer cell growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUBE3B itself is subject to tight post-translational regulation. A recent study identified the von Hippel–Lindau (VHL) tumor suppressor protein as a bona fide E3 ligase for UBE3B; VHL targets UBE3B for proteasomal degradation via lysine 48-linked polyubiquitination at key residues, thereby adding an extra layer of control over its protein levels and activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Collectively, these findings underscore the multifaceted functions of UBE3B in neural development, mitochondrial regulation, and oncogenesis, highlighting its importance as a pivotal mediator of ubiquitin-dependent signaling pathways.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tzy-Wen L Gong, Li Huang, Steven J Warner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genomics (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0888-7543(03)00111-3"}], "href": "https://doi.org/10.1016/s0888-7543(03"}, {"type": "t", "text": "00111-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12837265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12837265"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laura J Bierut, Arpana Agrawal, Kathleen K Bucholz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study of alcohol dependence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0911109107"}], "href": "https://doi.org/10.1073/pnas.0911109107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20202923"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20202923"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lina Basel-Vanagaite, Bruno Dallapiccola, Ramiro Ramirez-Solis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2012.10.011"}], "href": "https://doi.org/10.1016/j.ajhg.2012.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23200864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23200864"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elisabetta Flex, Andrea Ciolfi, Viviana Caputo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of function of the E3 ubiquitin-protein ligase UBE3B causes Kaufman oculocerebrofacial syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2012-101405"}], "href": "https://doi.org/10.1136/jmedgenet-2012-101405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23687348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23687348"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Lina Basel-Vanagaite, Rüstem Yilmaz, Sha Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the clinical and mutational spectrum of Kaufman oculocerebrofacial syndrome with biallelic UBE3B mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-014-1436-2"}], "href": "https://doi.org/10.1007/s00439-014-1436-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24615390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24615390"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Christeen Ramane J Pedurupillay, Tuva Barøy, Asbjørn Holmgren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaufman oculocerebrofacial syndrome in sisters with novel compound heterozygous mutation in UBE3B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36944"}], "href": "https://doi.org/10.1002/ajmg.a.36944"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25691420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25691420"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ariana Kariminejad, Norbert Fonya Ajeawung, Bita Bozorgmehr, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaufman oculo-cerebro-facial syndrome in a child with small and absent terminal phalanges and absent nails."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2016.151"}], "href": "https://doi.org/10.1038/jhg.2016.151"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28003643"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28003643"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Rüstem Yilmaz, Katalin Szakszon, Anna Altmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Kaufman oculocerebrofacial syndrome: Novel UBE3B mutations and clinical features in four unrelated patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38538"}], "href": "https://doi.org/10.1002/ajmg.a.38538"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29160006"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29160006"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maha S Zaki, Ghada A Otaify, Samira Ismail, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Blepharophimosis-ptosis-intellectual disability syndrome: A report of nine Egyptian patients with further expansion of phenotypic and mutational spectrum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.61857"}], "href": "https://doi.org/10.1002/ajmg.a.61857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32949109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32949109"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "AlBandary Albakheet, Duaa Almuallami, Rawan Almass, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel UBE3B mutations: report of eight patients with Kaufman oculocerebrofacial syndrome with additional clinical findings from a highly consanguineous population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Dysmorphol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MCD.0000000000000486"}], "href": "https://doi.org/10.1097/MCD.0000000000000486"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38410982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38410982"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Andrea Braganza, Jianfeng Li, Xuemei Zeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3B Is a Calmodulin-regulated, Mitochondrion-associated E3 Ubiquitin Ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.766824"}], "href": "https://doi.org/10.1074/jbc.M116.766824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28003368"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28003368"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ke Li, Feng Wang, Zhao-Na Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-20107-1"}], "href": "https://doi.org/10.1038/s41467-020-20107-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33298911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33298911"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yijie Wang, Xiong Liu, Min Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3B promotes breast cancer progression by antagonizing HIF-2α degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-023-02842-z"}], "href": "https://doi.org/10.1038/s41388-023-02842-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37783786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37783786"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shuo Wang, Huiyan Li, Xiong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VHL suppresses UBE3B-mediated breast tumor growth and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-06844-x"}], "href": "https://doi.org/10.1038/s41419-024-06844-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38914543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38914543"}]}]}]}
Synonyms	BPIDS, KOS
Proteins	UBE3B_HUMAN
NCBI Gene ID	89910
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE3B has 5,984 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 132 datasets.

Click the + buttons to view associations for UBE3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by UBE3B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE3B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UBE3B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with UBE3B gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE3B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UBE3B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with UBE3B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with UBE3B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UBE3B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UBE3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UBE3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UBE3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with UBE3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with UBE3B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UBE3B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving UBE3B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving UBE3B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UBE3B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.