UBE3C Gene

Name	ubiquitin protein ligase E3C
Description	Enables ubiquitin protein ligase activity. Involved in protein K29-linked ubiquitination; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUBE3C is a HECT‐domain ubiquitin ligase that plays a central role in maintaining cellular protein homeostasis. Biochemical and structural studies have established that UBE3C catalyzes the assembly of polyubiquitin chains on diverse substrates, thereby targeting them for proteasomal degradation and ensuring efficient clearance of misfolded or partially degraded proteins. Detailed analyses have defined critical structural determinants in its HECT domain that govern its activity—including autoubiquitination and the E2–E3 transthiolation process—which, in turn, allows the ligase to adapt proteasome processivity in response to increased levels of ubiquitinated substrates and even participates in antiviral defense by targeting viral proteins for degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also implicates UBE3C in modulating inflammatory responses and promoting tumor progression. Genetic studies have suggested that variations in UBE3C may influence complex traits such as antidepressant response and airway inflammatory conditions, including aspirin-intolerant asthma. In the oncological context, UBE3C is frequently overexpressed, where it drives epithelial-to-mesenchymal transition, enhances cancer stem-like properties, and activates protumorigenic signaling pathways (for example, by promoting β-catenin signaling via degradation of regulatory proteins such as AXIN1). Furthermore, UBE3C targets tumor suppressors—for instance, by ubiquitinating AHNAK in non-small-cell lung cancer and contributing to glioma cell invasiveness—and its expression can be modulated by microRNAs in hepatocellular carcinoma and breast cancer. Together, these studies underscore the pivotal contribution of UBE3C to cancer cell proliferation, invasion, and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in protein quality control and oncogenesis, aberrant UBE3C function has been linked to neuronal pathologies. Recent work in motor neuron models has revealed that complex structural alterations that encompass part of the UBE3C gene can result in the formation of novel fusion transcripts, which are associated with axonal degeneration and distal hereditary motor neuropathy. Moreover, pathogenic variation in ubiquitin ligase genes—including UBE3C—has emerged as a contributing mechanism in neurodevelopmental syndromes, highlighting its broad physiological relevance across multiple systems."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianxin You, Min Wang, Tsutomu Aoki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212887200"}], "href": "https://doi.org/10.1074/jbc.M212887200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12692129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12692129"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bernard W Chu, Kyle M Kovary, Johan Guillaume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The E3 ubiquitin ligase UBE3C enhances proteasome processivity by ubiquitinating partially proteolyzed substrates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.499350"}], "href": "https://doi.org/10.1074/jbc.M113.499350"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24158444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24158444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chueh-Ling Kuo, Alfred Lewis Goldberg "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitinated proteins promote the association of proteasomes with the deubiquitinating enzyme Usp14 and the ubiquitin ligase Ube3c."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1701734114"}], "href": "https://doi.org/10.1073/pnas.1701734114"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28396413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28396413"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Sunil Singh, J Sivaraman "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of HECT domain of UBE3C E3 ligase and its ubiquitination activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20200027"}], "href": "https://doi.org/10.1042/BCJ20200027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32039437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32039437"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-21715-1"}], "href": "https://doi.org/10.1038/s41467-021-21715-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33637724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33637724"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Boming Cui, Ge Yang, Haiyan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3C restricts EV-A71 replication by ubiquitination-dependent degradation of 2C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/jvi.01335-24"}], "href": "https://doi.org/10.1128/jvi.01335-24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39212385"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39212385"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Holly A Garriock, Jeffrey B Kraft, Stanley I Shyn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genomewide association study of citalopram response in major depressive disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopsych.2009.08.029"}], "href": "https://doi.org/10.1016/j.biopsych.2009.08.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19846067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19846067"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jin Sol Lee, Jeong-Hyun Kim, Joon Seol Bae, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association analysis of UBE3C polymorphisms in Korean aspirin-intolerant asthmatic patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Allergy Asthma Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.anai.2010.07.006"}], "href": "https://doi.org/10.1016/j.anai.2010.07.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20934631"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20934631"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yanxing Yu, Gary S Hayward "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunity (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.immuni.2010.11.027"}], "href": "https://doi.org/10.1016/j.immuni.2010.11.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21167755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21167755"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Charisse Flerida A Pasaje, Jeong-Hyun Kim, Byung-Lae Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3C genetic variations as potent markers of nasal polyps in Korean asthma patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2011.104"}], "href": "https://doi.org/10.1038/jhg.2011.104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21881582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21881582"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jia-Hao Jiang, Yan-Feng Liu, Ai-Wu Ke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical significance of the ubiquitin ligase UBE3C in hepatocellular carcinoma revealed by exome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.27012"}], "href": "https://doi.org/10.1002/hep.27012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24425307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24425307"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ji Ling Wen, Xiao Fei Wen, Rong Bing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3C promotes growth and metastasis of renal cell carcinoma via activating Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0115622"}], "href": "https://doi.org/10.1371/journal.pone.0115622"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25658088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25658088"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Si-Jian Pan, Shi-Kun Zhan, Wei-Zhong Ji, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep11066"}], "href": "https://doi.org/10.1038/srep11066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26067607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26067607"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Li Tang, Xue-Mei Yi, Jia Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin ligase UBE3C promotes melanoma progression by increasing epithelial-mesenchymal transition in melanoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7393"}], "href": "https://doi.org/10.18632/oncotarget.7393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26894856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26894856"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jiaxiu Xiong, Bo Wei, Qinong Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-30a-5p/UBE3C axis regulates breast cancer cell proliferation and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2016.03.069"}], "href": "https://doi.org/10.1016/j.bbrc.2016.03.069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27003255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27003255"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jie Tao, Zhikui Liu, Yufeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-542-3p inhibits metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting UBE3C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2017.06.070"}], "href": "https://doi.org/10.1016/j.biopha.2017.06.070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28666208"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28666208"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jie Gu, Wei Mao, Wenjia Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-protein ligase E3C maintains non-small-cell lung cancer stemness by targeting AHNAK-p53 complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.11.029"}], "href": "https://doi.org/10.1016/j.canlet.2018.11.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30503554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30503554"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yu Zhang, Jiapeng Xu, Hongbing Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UBE3C promotes proliferation and inhibits apoptosis by activating the β-catenin signaling via degradation of AXIN1 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgaa098"}], "href": "https://doi.org/10.1093/carcin/bgaa098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32930707"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32930707"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Anthony N Cutrupi, Ramesh K Narayanan, Gonzalo Perez-Siles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awac424"}], "href": "https://doi.org/10.1093/brain/awac424"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36380488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36380488"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Eissa A Faqeih, Malak Ali Alghamdi, Marwa A Almahroos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Biallelic variants in HECT E3 paralogs, HECTD4 and UBE3C, encoding ubiquitin ligases cause neurodevelopmental disorders that overlap with Angelman syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gim.2022.10.006"}], "href": "https://doi.org/10.1016/j.gim.2022.10.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36401616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36401616"}]}]}]}
Synonyms	HECTH2
Proteins	UBE3C_HUMAN
NCBI Gene ID	9690
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UBE3C has 9,184 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 120 datasets.

Click the + buttons to view associations for UBE3C from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UBE3C Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE3C gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE3C gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UBE3C gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UBE3C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UBE3C gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UBE3C gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE3C gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE3C gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UBE3C gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UBE3C gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE3C gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE3C gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UBE3C protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE3C gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UBE3C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UBE3C gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with UBE3C gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UBE3C protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UBE3C gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UBE3C protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UBE3C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UBE3C protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UBE3C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UBE3C protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UBE3C gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UBE3C gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UBE3C gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UBE3C gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UBE3C gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UBE3C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UBE3C gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UBE3C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UBE3C gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UBE3C gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UBE3C gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UBE3C gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UBE3C from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with UBE3C gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UBE3C gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with UBE3C gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.