HGNC Family | Endogenous ligands |
Name | urocortin 3 |
Description | This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family of proteins. The encoded preproprotein is proteolytically processed to generate the mature peptide hormone, which is secreted by pancreatic beta and alpha cells. This hormone is an endogenous ligand for corticotropin-releasing factor receptor 2 and may regulate insulin secretion in response to plasma glucose levels. Patients with type 2 diabetes exhibit reduced levels of the encoded protein in beta cells. In the brain, the encoded protein may be responsible for the effects of stress on appetite. [provided by RefSeq, May 2016] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUrocortin 3 (UCN3), a member of the corticotropin‐releasing factor (CRF) peptide family and a selective ligand for CRF receptor type 2, has been implicated in central neuromodulation. Genetic studies have linked UCN3 with major depressive disorder and shown that its expression or structural modifications can influence antidepressant response and ameliorate memory deficits, while electrophysiological studies indicate that UCN3 modulates neuronal excitability through CRF receptors and associated GIRK channel activation. These findings support a role for UCN3 in stress responsiveness, mood regulation, and cognitive processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn peripheral tissues, UCN3 plays crucial roles in cardiovascular and metabolic regulation. In pancreatic islets UCN3 is stored in mature β‐cells and is co‐released with insulin where it potentiates glucose‐stimulated somatostatin secretion from δ‐cells, establishing a negative feedback loop essential for glycemic control and serving as a marker for β‐cell maturity. UCN3 is also expressed in the heart, kidney, adrenal glands, and placenta, where its paracrine actions evoke cardioprotective effects and participate in the response to hypoxic stress. Furthermore, altered UCN3 expression has been observed in heart failure and metabolic disorders, underscoring its role in maintaining organ homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUCN3 also exerts important modulatory effects in reproductive and other peripheral systems. It is expressed in adipose tissue and the gastrointestinal tract – where it regulates angiogenic mediators such as VEGF‐A – as well as in the endometrium, placenta, and ovarian cells, modulating cytokine secretion and steroidogenesis. Elevated or altered UCN3 levels have been associated with conditions such as endometriosis, polycystic ovary syndrome, and arthritic joint inflammation, highlighting its multifaceted paracrine and endocrine actions in inflammatory, reproductive, and metabolic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "M-L Wong, C Dong, J Maestre-Mesa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2008.59"}], "href": "https://doi.org/10.1038/mp.2008.59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18504423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18504423"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Elisabeth B Binder, Michael J Owens, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Gen Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archgenpsychiatry.2010.18"}], "href": "https://doi.org/10.1001/archgenpsychiatry.2010.18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20368512"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20368512"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chun-Ping Chu, Wen-Zhe Jin, Yan-Hua Bing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of stresscopin on rat hypothalamic paraventricular nucleus neurons in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0053863"}], "href": "https://doi.org/10.1371/journal.pone.0053863"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23349753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23349753"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kinga Rákosi, Tanaka Masaru, Márta Zarándia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Short analogs and mimetics of human urocortin 3 display antidepressant effects in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2014.09.023"}], "href": "https://doi.org/10.1016/j.peptides.2014.09.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25304878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25304878"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gyula Telegdy, Anita Kármen Kovács, Kinga Rákosi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Amino Acids (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00726-016-2268-2"}], "href": "https://doi.org/10.1007/s00726-016-2268-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27262310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27262310"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Talitha van der Meulen, Cynthia J Donaldson, Elena Cáceres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3872"}], "href": "https://doi.org/10.1038/nm.3872"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26076035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26076035"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kazuhiro Takahashi, Kazuhito Totsune, Osamu Murakami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of urocortin III/stresscopin in human heart and kidney."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2003-031663"}], "href": "https://doi.org/10.1210/jc.2003-031663"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15070962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15070962"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A Chanalaris, K M Lawrence, A Stephanou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protective effects of the urocortin homologues stresscopin (SCP) and stresscopin-related peptide (SRP) against hypoxia/reoxygenation injury in rat neonatal cardiomyocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0022-2828(03)00244-x"}], "href": "https://doi.org/10.1016/s0022-2828(03"}, {"type": "t", "text": "00244-x) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14519439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14519439"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Masayuki Saruta, Kazuhiro Takahashi, Takashi Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urocortin 3/stresscopin in human colon: possible modulators of gastrointestinal function during stressful conditions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2005.01.014"}], "href": "https://doi.org/10.1016/j.peptides.2005.01.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15949638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15949638"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kazuhiro Takahashi, Kazuhito Totsune, Masayuki Saruta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of urocortin 3/stresscopin in human adrenal glands and adrenal tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2005.06.017"}], "href": "https://doi.org/10.1016/j.peptides.2005.06.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16095756"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16095756"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alberto Imperatore, Pasquale Florio, Paulo B Torres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Obstet Gynecol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajog.2005.12.048"}], "href": "https://doi.org/10.1016/j.ajog.2005.12.048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16626608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16626608"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Talitha van der Meulen, Mark O Huising "}, {"type": "b", "children": [{"type": "t", "text": "Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Rev Diabet Stud (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1900/RDS.2014.11.115"}], "href": "https://doi.org/10.1900/RDS.2014.11.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25148370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25148370"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Colin G Stirrat, Sowmya Venkatasubramanian, Tania Pawade, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Clin Pharmacol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bcp.13033"}], "href": "https://doi.org/10.1111/bcp.13033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27275843"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27275843"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anna P Pilbrow, Kathy A Lewis, Marilyn H Perrin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/en.2016-1448"}], "href": "https://doi.org/10.1210/en.2016-1448"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27754786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27754786"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Pınar Alarslan, Gokcen Unal Kocabas, Ismail Demir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1753-0407.13020"}], "href": "https://doi.org/10.1111/1753-0407.13020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31893569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31893569"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Marcus F Flisher, Donghan Shin, Mark O Huising "}, {"type": "b", "children": [{"type": "t", "text": "Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2022.170748"}], "href": "https://doi.org/10.1016/j.peptides.2022.170748"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35065098"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35065098"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Janette Seres, Stefan R Bornstein, Peter Seres, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corticotropin-releasing hormone system in human adipose tissue."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Endocrinol Metab (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/jc.2003-031299"}], "href": "https://doi.org/10.1210/jc.2003-031299"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14764822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14764822"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Romina Novembri, Patrizia Carrarelli, Paolo Toti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Urocortin 2 and urocortin 3 in endometriosis: evidence for a possible role in inflammatory response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Hum Reprod (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/molehr/gar020"}], "href": "https://doi.org/10.1093/molehr/gar020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454316"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alberto Imperatore, Alessandro Rolfo, Felice Petraglia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719110373147"}], "href": "https://doi.org/10.1177/1933719110373147"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20616367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20616367"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "R Novembri, M Torricelli, E Bloise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effects of urocortin 2 and urocortin 3 on IL-10 and TNF-α expression and secretion from human trophoblast explants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Placenta (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.placenta.2011.09.013"}], "href": "https://doi.org/10.1016/j.placenta.2011.09.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22000474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22000474"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sang Hoon Rhee, Elise L Ma, Yunna Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M115.678979"}], "href": "https://doi.org/10.1074/jbc.M115.678979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26350463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26350463"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Selene Pérez-García, Yasmina Juarranz, Mar Carrión, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping the CRF-urocortins system in human osteoarthritic and rheumatoid synovial fibroblasts: effect of vasoactive intestinal peptide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22687"}], "href": "https://doi.org/10.1002/jcp.22687"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21360527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21360527"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Muzaffer Temur, Özgür Yilmaz, Saliha Aksun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Endocrinol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/09513590.2015.1110135"}], "href": "https://doi.org/10.3109/09513590.2015.1110135"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26488073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26488073"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Pasquale Florio, Paulo B Torres, Michela Torricelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human endometrium expresses urocortin II and III messenger RNA and peptides."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2006.05.041"}], "href": "https://doi.org/10.1016/j.fertnstert.2006.05.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17074339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17074339"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ai Yata, Koji Nakabayashi, Senn Wakahashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Reprod (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/humrep/dep063"}], "href": "https://doi.org/10.1093/humrep/dep063"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19351656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19351656"}]}]}]}
|
Synonyms | UCNIII |
Proteins | UCN3_HUMAN |
NCBI Gene ID | 114131 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
UCN3 has 2,316 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 75 datasets.
Click the + buttons to view associations for UCN3 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of UCN3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of UCN3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of UCN3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of UCN3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UCN3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UCN3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of UCN3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of UCN3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with UCN3 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UCN3 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of UCN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of UCN3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing UCN3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with UCN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with UCN3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of UCN3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with UCN3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with UCN3 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with UCN3 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with UCN3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by UCN3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with UCN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with UCN3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with UCN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with UCN3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UCN3 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UCN3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of UCN3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing UCN3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with UCN3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with UCN3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing UCN3 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of UCN3 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving UCN3 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving UCN3 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving UCN3 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing UCN3 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by UCN3 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by UCN3 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by UCN3 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of UCN3 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of UCN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of UCN3 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of UCN3 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of UCN3 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of UCN3 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with UCN3 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by UCN3 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for UCN3 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of UCN3 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of UCN3 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by UCN3 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of UCN3 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by UCN3 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
NURSA Protein Complexes | protein complexs containing UCN3 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for UCN3 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of UCN3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of UCN3 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving UCN3 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving UCN3 protein from the Wikipathways PFOCR 2024 dataset. | |
Reactome Pathways 2024 | pathways involving UCN3 protein from the Reactome Pathways 2024 dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of UCN3 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UCN3 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of UCN3 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of UCN3 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of UCN3 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of UCN3 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of UCN3 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with UCN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with UCN3 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |