| HGNC Family | Glycosyltransferases |
| Name | UDP glucuronosyltransferase 1 family, polypeptide A10 |
| Description | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity on mycophenolic acid, coumarins, and quinolines. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUDP‐glucuronosyltransferase 1A10 (UGT1A10) plays a central role in the detoxification and metabolic inactivation of a wide range of xenobiotics and endogenous compounds. UGT1A10 contributes to the glucuronidation of anticancer drug metabolites such as SN-38—the active metabolite of irinotecan"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "—as well as tamoxifen metabolites"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and tobacco‐smoke carcinogen metabolites including those of benzo(a)pyrene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In the gastrointestinal tract where UGT1A10 is highly expressed, it additionally glucuronidates estrogens and phytoestrogens, natural aromatic acids and bioflavonoids"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ";"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", psilocin"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", darexaban"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and even novel antitumor agents such as C-1311 and C-1305, where it can influence not only detoxification but also bioactivation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Furthermore, UGT1A10 exhibits superior catalytic efficiency toward estrone and 16α-hydroxyestrone conjugation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", detoxifies the tobacco-specific procarcinogen metabolite NNAL"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and even processes hydroxywarfarin metabolites through a substrate-selective active site motif."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Studies with flavonoid substrates further underscore its broad substrate specificity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its catalytic functions, UGT1A10 displays distinctive regulatory and structural features that underlie its tissue-specific expression and substrate specificity. The enzyme is predominantly expressed in the intestine due, in part, to epigenetic mechanisms—such as promoter hypermethylation in liver versus hypomethylation in the gut"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "—and promoter elements that enhance its extrahepatic transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Unexpectedly, UGT1A10 mRNA can also be detected in human hepatocytes and is inducible by xenobiotics"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", while mutagenesis studies have highlighted critical active-site residues (such as F90 and F93) that govern substrate binding and intrinsic activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Moreover, tissue-specific transcription factors, including CDX2 and HNF4α, synergistically regulate its expression and contribute to presystemic first-pass metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic variation in UGT1A10 further modulates its enzymatic capacity and clinical impact. Analysis of UGT1A polymorphisms has revealed conserved nucleotide variants that, while not directly associated with hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ", may influence the detoxification efficiency in individuals with a predisposition to cancer, such as patients with familial adenomatous polyposis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " In addition, innovative translational approaches utilizing graphene nano-cages have enabled the assembly of bienzyme complexes incorporating cytochrome P450 1A2 and UGT1A10 to study sequential drug metabolism"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", thereby reinforcing the clinical relevance of UGT1A10 in individualized therapy and drug design.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hironobu Minami, Kimie Sai, Mayumi Saeki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1"}, {"type": "i", "children": [{"type": "t", "text": "6 and "}]}, {"type": "t", "text": "28."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e328014341f"}], "href": "https://doi.org/10.1097/FPC.0b013e328014341f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17558305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17558305"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrea S Blevins-Primeau, Dongxiao Sun, Gang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-3708"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-3708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19244109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19244109"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Abul Elahi, Jean Bendaly, Zhong Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of UGT1A10 polymorphisms and their association with orolaryngeal carcinoma risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.11587"}], "href": "https://doi.org/10.1002/cncr.11587"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12910533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12910533"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nikhil K Basu, Shigeki Kubota, Meselhy R Meselhy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M401396200"}], "href": "https://doi.org/10.1074/jbc.M401396200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117964"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "R H Lewinsky, P A Smith, P I Mackenzie "}, {"type": "b", "children": [{"type": "t", "text": "Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xenobiotica (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/00498250400028189"}], "href": "https://doi.org/10.1080/00498250400028189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16019943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16019943"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nenad Manevski, Mika Kurkela, Camilla Höglund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.109.031138"}], "href": "https://doi.org/10.1124/dmd.109.031138"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20007669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20007669"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Toshifumi Shiraga, Kanako Yajima, Kenta Suzuki, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Metabolic transformation of antitumor acridinone C-1305 but not C-1311 via selective cellular expression of UGT1A10 increases cytotoxic response: implications for clinical use."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.112.047811"}], "href": "https://doi.org/10.1124/dmd.112.047811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23160818"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23160818"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Roope A Kallionpää, Erkka Järvinen, Moshe Finel "}, {"type": "b", "children": [{"type": "t", "text": "Glucuronidation of estrone and 16α-hydroxyestrone by human UGT enzymes: The key roles of UGT1A10 and UGT2B7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Steroid Biochem Mol Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jsbmb.2015.07.013"}], "href": "https://doi.org/10.1016/j.jsbmb.2015.07.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26220143"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26220143"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Rene M Balliet, Gang Chen, Ryan W Dellinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UDP-glucuronosyltransferase 1A10: activity against the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and a potential role for a novel UGT1A10 promoter deletion polymorphism in cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.109.030569"}], "href": "https://doi.org/10.1124/dmd.109.030569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20007297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20007297"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rajat Banerjee, Matthew W Pennington, Amanda Garza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi8006127"}], "href": "https://doi.org/10.1021/bi8006127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18570380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18570380"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lan Tang, Ling Ye, Rashim Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharm (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/mp900223c"}], "href": "https://doi.org/10.1021/mp900223c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20297805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20297805"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shingo Oda, Tatsuki Fukami, Tsuyoshi Yokoi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic regulation of the tissue-specific expression of human UDP-glucuronosyltransferase (UGT) 1A10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bcp.2013.11.001"}], "href": "https://doi.org/10.1016/j.bcp.2013.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24239897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24239897"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Philip A Gregory, Dione A Gardner-Stephen, Rikke H Lewinsky, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305565200"}], "href": "https://doi.org/10.1074/jbc.M305565200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12847094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12847094"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Xin Li, Stacie Bratton, Anna Radominska-Pandya "}, {"type": "b", "children": [{"type": "t", "text": "Human UGT1A8 and UGT1A10 mRNA are expressed in primary human hepatocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Pharmacokinet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2133/dmpk.22.152"}], "href": "https://doi.org/10.2133/dmpk.22.152"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17603215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17603215"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Camilla Höglund, Nina Sneitz, Anna Radominska-Pandya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenylalanine 93 of the human UGT1A10 plays a major role in the interactions of the enzyme with estrogens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Steroids (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.steroids.2011.07.017"}], "href": "https://doi.org/10.1016/j.steroids.2011.07.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21846474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21846474"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Nurul Mubarokah, Julie-Ann Hulin, Peter I Mackenzie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4"}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "α"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Is Mediated by a Novel Composite Regulatory Element."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.117.110619"}], "href": "https://doi.org/10.1124/mol.117.110619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29519853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29519853"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ursula Ehmer, Arndt Vogel, Jan Karl Schütte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.20131"}], "href": "https://doi.org/10.1002/hep.20131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15057901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15057901"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "M Berkhout, H M J Roelofs, R H M te Morsche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Surg (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bjs.6027"}], "href": "https://doi.org/10.1002/bjs.6027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18161889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18161889"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jusheng Lu, Yuanjian Zhang, Henan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Electrochemically driven drug metabolism via a CYP1A2-UGT1A10 bienzyme confined in a graphene nano-cage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Chem Commun (Camb) (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1039/c4cc06200k"}], "href": "https://doi.org/10.1039/c4cc06200k"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25264962"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25264962"}]}]}]}
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| Synonyms | UGT1-01, UGT1-10, UGT1J, UGT-1A, UGT1A1, UGT-1J, UGT1.1, UGT1.10, UGT1A, UDPGT |
| Proteins | UD110_HUMAN |
| NCBI Gene ID | 54575 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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UGT1A10 has 3,378 functional associations with biological entities spanning 8 categories (molecular profile, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 88 datasets.
Click the + buttons to view associations for UGT1A10 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UGT1A10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of UGT1A10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of UGT1A10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of UGT1A10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with UGT1A10 protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UGT1A10 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of UGT1A10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of UGT1A10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing UGT1A10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing UGT1A10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with UGT1A10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with UGT1A10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of UGT1A10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with UGT1A10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with UGT1A10 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with UGT1A10 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with UGT1A10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by UGT1A10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with UGT1A10 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with UGT1A10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with UGT1A10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with UGT1A10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with UGT1A10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| DrugBank Drug Targets | interacting drugs for UGT1A10 protein from the curated DrugBank Drug Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UGT1A10 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of UGT1A10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of UGT1A10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with UGT1A10 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with UGT1A10 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of UGT1A10 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with UGT1A10 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing UGT1A10 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of UGT1A10 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of UGT1A10 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding UGT1A10 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving UGT1A10 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving UGT1A10 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving UGT1A10 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing UGT1A10 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing UGT1A10 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing UGT1A10 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by UGT1A10 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by UGT1A10 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by UGT1A10 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of UGT1A10 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of UGT1A10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of UGT1A10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with UGT1A10 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with UGT1A10 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with UGT1A10 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for UGT1A10 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of UGT1A10 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of UGT1A10 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of UGT1A10 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with UGT1A10 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for UGT1A10 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of UGT1A10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of UGT1A10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving UGT1A10 protein from the KEGG Pathways dataset. | |
| KEGG Pathways 2026 | pathways involving UGT1A10 protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of UGT1A10 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with UGT1A10 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of UGT1A10 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain UGT1A10 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting UGT1A10 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of UGT1A10 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of UGT1A10 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| MW Enzyme Metabolite Associations | interacting metabolites for UGT1A10 protein from the MW Gene Metabolite Associations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for UGT1A10 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of UGT1A10 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving UGT1A10 protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with UGT1A10 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| Reactome Pathways 2024 | pathways involving UGT1A10 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of UGT1A10 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at UGT1A10 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of UGT1A10 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of UGT1A10 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with UGT1A10 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of UGT1A10 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of UGT1A10 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of UGT1A10 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of UGT1A10 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of UGT1A10 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of UGT1A10 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with UGT1A10 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with UGT1A10 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving UGT1A10 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving UGT1A10 protein from the WikiPathways Pathways 2024 dataset. | |
