{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUGT1A7 is a member of the UDP‐glucuronosyltransferase enzyme family critically involved in the glucuronidation process that detoxifies both endogenous compounds and xenobiotics. In the context of anticancer therapy, UGT1A7 contributes to the inactivation and elimination of cytotoxic agents such as SN-38, the active metabolite of irinotecan. Variations in this isoform—as observed in patients with advanced non–small-cell lung cancer and colorectal malignancies—can affect irinotecan pharmacokinetics and treatment outcomes, highlighting its clinical importance in drug metabolism and toxicity modulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in drug metabolism, UGT1A7 is instrumental in detoxifying environmental carcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons. Numerous studies have reported that genetic polymorphisms in UGT1A7—most notably low‐activity alleles like UGT1A7*3—are associated with an increased risk for several cancers, including hepatocellular, colorectal, lung, pancreatic, and cancers of the proximal digestive tract. These associations underscore the enzyme’s protective function in metabolizing potentially carcinogenic compounds and influencing individual susceptibility to cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "23"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistic studies have further revealed that UGT1A7’s catalytic efficiency and substrate selectivity are subject to modulation by protein–protein interactions and post‐translational modifications such as phosphorylation. Such regulation not only influences its ability to metabolize a broad array of substrates—including flavonoids and other dietary components—but also helps explain interindividual differences in detoxification capacity among various tissues. In some settings, for instance during the metabolism of mycophenolic acid, UGT1A7 genetic variants may not lead to overt differences in drug clearance, underscoring the complex interplay of genetic and regulatory factors that govern its function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "24", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Leslie E Carlini, Neal J Meropol, John Bever, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15709193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15709193"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ji-Youn Han, Hyeong-Seok Lim, Eun Soon Shin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2005.03.0239"}], "href": "https://doi.org/10.1200/JCO.2005.03.0239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16636344"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16636344"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ken-ichi Fujita, Yuichi Ando, Fumio Nagashima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic linkage of UGT1A7 and UGT1A9 polymorphisms to UGT1A1*6 is associated with reduced activity for SN-38 in Japanese patients with cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Chemother Pharmacol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00280-006-0396-1"}], "href": "https://doi.org/10.1007/s00280-006-0396-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17406868"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17406868"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hironobu Minami, Kimie Sai, Mayumi Saeki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Irinotecan pharmacokinetics/pharmacodynamics and UGT1A genetic polymorphisms in Japanese: roles of UGT1A1"}, {"type": "i", "children": [{"type": "t", "text": "6 and "}]}, {"type": "t", "text": "28."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacogenet Genomics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FPC.0b013e328014341f"}], "href": "https://doi.org/10.1097/FPC.0b013e328014341f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17558305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17558305"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tim O Lankisch, Christoph Schulz, Thomas Zwingers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gilbert's Syndrome and irinotecan toxicity: combination with UDP-glucuronosyltransferase 1A7 variants increases risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-07-2517"}], "href": "https://doi.org/10.1158/1055-9965.EPI-07-2517"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18349289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18349289"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Federico Innocenti, Deanna L Kroetz, Erin Schuetz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2008.20.6300"}], "href": "https://doi.org/10.1200/JCO.2008.20.6300"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19349540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19349540"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Erika Cecchin, Federico Innocenti, Mario D'Andrea, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Predictive role of the UGT1A1, UGT1A7, and UGT1A9 genetic variants and their haplotypes on the outcome of metastatic colorectal cancer patients treated with fluorouracil, leucovorin, and irinotecan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2008.19.0314"}], "href": "https://doi.org/10.1200/JCO.2008.19.0314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19364970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19364970"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A Vogel, S Kneip, A Barut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/gast.2001.28655"}], "href": "https://doi.org/10.1053/gast.2001.28655"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11677206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11677206"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "C P Strassburg, A Vogel, S Kneip, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gut (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/gut.50.6.851"}], "href": "https://doi.org/10.1136/gut.50.6.851"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12010889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12010889"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Christoph Köhle, Bernd Möhrle, Peter A Münzel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1"}, {"type": "i", "children": [{"type": "t", "text": "28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7"}]}, {"type": "t", "text": "3) in Caucasians and Egyptians."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Pharmacol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0006-2952(03)00074-1"}], "href": "https://doi.org/10.1016/s0006-2952(03"}, {"type": "t", "text": "00074-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12732365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12732365"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Johann Ockenga, Arndt Vogel, Niels Teich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0016-5085(03)00294-4"}], "href": "https://doi.org/10.1016/s0016-5085(03"}, {"type": "t", "text": "00294-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12806614"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12806614"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "E M J van der Logt, S M Bergevoet, H M J Roelofs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms in UDP-glucuronosyltransferases and glutathione S-transferases and colorectal cancer risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgh251"}], "href": "https://doi.org/10.1093/carcin/bgh251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15319294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15319294"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "May-Jen Huang, Sien-Sing Yang, Min-Shung Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v11.i6.797"}], "href": "https://doi.org/10.3748/wjg.v11.i6.797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15682470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15682470"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Kung-Sheng Tang, Hui-Fen Chiu, Hong-Hwa Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Link between colorectal cancer and polymorphisms in the uridine-diphosphoglucuronosyltransferase 1A7 and 1A1 genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v11.i21.3250"}], "href": "https://doi.org/10.3748/wjg.v11.i21.3250"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15929176"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15929176"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lesley M Butler, Yannick Duguay, Robert C Millikan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Joint effects between UDP-glucuronosyltransferase 1A7 genotype and dietary carcinogen exposure on risk of colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-04-0682"}], "href": "https://doi.org/10.1158/1055-9965.EPI-04-0682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16030093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16030093"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chien-Sen Tseng, Kung-Sheng Tang, Hoi-Wan Lo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UDP-glucuronosyltransferase 1A7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Gastroenterol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1572-0241.2005.41857.x"}], "href": "https://doi.org/10.1111/j.1572-0241.2005.41857.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16086712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16086712"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jun Araki, Yoshinao Kobayashi, Motoh Iwasa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphism of UDP-glucuronosyltransferase 1A7 gene: a possible new risk factor for lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cancer (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejca.2005.04.043"}], "href": "https://doi.org/10.1016/j.ejca.2005.04.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16143514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16143514"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "M Verlaan, J P H Drenth, K Truninger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms of UDP-glucuronosyltransferase 1A7 are not involved in pancreatic diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmg.2005.032599"}], "href": "https://doi.org/10.1136/jmg.2005.032599"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16199544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16199544"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Kun Chen, Mingjuan Jin, Yimin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic polymorphisms of the uridine diphosphate glucuronosyltransferase 1A7 and colorectal cancer risk in relation to cigarette smoking and alcohol drinking in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1440-1746.2005.04032.x"}], "href": "https://doi.org/10.1111/j.1440-1746.2005.04032.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16724991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16724991"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ada Piepoli, Annamaria Gentile, Maria Rosa Valvano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v12.i39.6343"}], "href": "https://doi.org/10.3748/wjg.v12.i39.6343"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17072959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17072959"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sung Su Yea, Sang Seop Lee, Woo-Young Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variations and haplotypes of UDP-glucuronosyltransferase 1A locus in a Korean population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ther Drug Monit (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FTD.0b013e3181633824"}], "href": "https://doi.org/10.1097/FTD.0b013e3181633824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18223459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18223459"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sun-Young Kong, Chang-Seok Ki, Byung Chul Yoo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UGT1A7 haplotype is associated with an increased risk of hepatocellular carcinoma in hepatitis B carriers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2007.00693.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2007.00693.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18271934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18271934"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "S R Park, S-Y Kong, J Rhee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phase II study of a triplet regimen of S-1 combined with irinotecan and oxaliplatin in patients with metastatic gastric cancer: clinical and pharmacogenetic results."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Oncol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/annonc/mdq435"}], "href": "https://doi.org/10.1093/annonc/mdq435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20860988"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20860988"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Haruhisa Machida, Kazuhiro Tsukamoto, Chun-Yang Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crohn's disease in Japanese is associated with a SNP-haplotype of N-acetyltransferase 2 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v11.i31.4833"}], "href": "https://doi.org/10.3748/wjg.v11.i31.4833"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16097053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16097053"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Kazuyuki Inoue, Masatomo Miura, Shigeru Satoh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ther Drug Monit (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/FTD.0b013e3180686146"}], "href": "https://doi.org/10.1097/FTD.0b013e3180686146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17529886"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17529886"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Nikhil K Basu, Labanyamoy Kole, Mousumi Basu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M800032200"}], "href": "https://doi.org/10.1074/jbc.M800032200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18556656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18556656"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Vincent Ménard, Hugo Girard, Mario Harvey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20946"}], "href": "https://doi.org/10.1002/humu.20946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19204906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19204906"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Lan Tang, Ling Ye, Rashim Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharm (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/mp900223c"}], "href": "https://doi.org/10.1021/mp900223c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20297805"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20297805"}]}]}]}