UNC119 Gene

Name	unc-119 homolog (C. elegans)
Description	This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUNC119 is a lipid‐binding adaptor protein that sequesters acylated cargo molecules, recognizing and encapsulating N-terminally modified peptides in a deep hydrophobic pocket. This molecular chaperone binds myristoylated and prenylated proteins and, through interactions with small G proteins (notably Arl3), facilitates the regulated release of high‐affinity cargos. In these capacities, UNC119 plays a central role in sorting and trafficking lipid-modified proteins to specialized subcellular compartments, particularly the ciliary membrane."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the visual system, UNC119 (also known as HRG4) is critical for photoreceptor function. It interacts with ARL2 and facilitates the light-dependent trafficking of the G protein transducin between the inner and outer segments of rod photoreceptors. This activity underpins proper photoreceptor signaling and the maintenance of synaptic integrity through precise spatial localization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond the retina, UNC119 is a key regulator of signaling in immune and developmental contexts. In T cells, it directs the plasma membrane targeting of the lymphocyte-specific kinase Lck, thereby initiating T cell receptor signaling, while mutations in UNC119 can lead to impaired T cell activation and immunodeficiency. In eosinophils, UNC119 associates with IL-5 receptor complexes to activate Src family kinases such as Lyn. Moreover, in fibroblasts, it influences myofibroblast differentiation via activation of kinases like Fyn and p38 MAPK. Its roles in cytokinesis, mediated through interactions with Rab11 and Src family kinases, further underscore its importance in cell-cycle progression and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, UNC119 plays an integral role in the spatial organization of Src family kinases and in membrane trafficking. By sequestering myristoylated kinases, UNC119 assists in maintaining their enrichment at the plasma membrane and modulates endocytic pathways by interacting with dynamin, effectively setting thresholds for vesicular internalization."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the context of oncogenesis, UNC119 appears to have dual roles. On one hand, it can promote apoptosis through interactions with tumor suppressors such as RASSF6 and p53, as observed by its capacity to stabilize p53 via facilitating RASSF6–MDM2 interactions and enhancing KRAS-mediated apoptotic signaling. On the other hand, elevated levels of UNC119 have been observed in hepatocellular carcinoma, where it contributes to tumor cell proliferation, migration, and invasion by modulating pathways such as Wnt/β-catenin and TGF-β/EMT. These findings indicate that UNC119’s precise role in tumorigenesis is context-dependent."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Houbin Zhang, Ryan Constantine, Sergey Vorobiev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 is required for G protein trafficking in sensory neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nn.2835"}], "href": "https://doi.org/10.1038/nn.2835"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21642972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21642972"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2012.257"}], "href": "https://doi.org/10.1038/emboj.2012.257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22960633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22960633"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mamta Jaiswal, Eyad K Fansa, Stefanie K Kösling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M116.741827"}], "href": "https://doi.org/10.1074/jbc.M116.741827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27481943"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27481943"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Louise A Stephen, Shehab Ismail "}, {"type": "b", "children": [{"type": "t", "text": "Shuttling and sorting lipid-modified cargo into the cilia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST20160122"}], "href": "https://doi.org/10.1042/BST20160122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27911709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27911709"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Francesca Jean, David Pilgrim "}, {"type": "b", "children": [{"type": "t", "text": "Coordinating the uncoordinated: UNC119 trafficking in cilia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejcb.2017.09.001"}], "href": "https://doi.org/10.1016/j.ejcb.2017.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28935136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28935136"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Akira Kobayashi, Shinya Kubota, Naoki Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(02)03766-3"}], "href": "https://doi.org/10.1016/s0014-5793(02"}, {"type": "t", "text": "03766-3) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12527357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12527357"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Kota N Gopalakrishna, Krishnarao Doddapuneni, Kimberly K Boyd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.268821"}], "href": "https://doi.org/10.1074/jbc.M111.268821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21712387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21712387"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Satyabrata Sinha, Anurima Majumder, Marycharmain Belcastro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and subcellular distribution of UNC119a, a protein partner of transducin α subunit in rod photoreceptors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2012.10.005"}], "href": "https://doi.org/10.1016/j.cellsig.2012.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23072788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23072788"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Osman Cen, Magdalena M Gorska, Susan J Stafford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of UNC119 as a novel activator of SRC-type tyrosine kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208261200"}], "href": "https://doi.org/10.1074/jbc.M208261200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12496276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12496276"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ramarao Vepachedu, Magdalena M Gorska, Neil Singhania, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.1.682"}], "href": "https://doi.org/10.4049/jimmunol.179.1.682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17579091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17579091"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Magdalena M Gorska, Qiaoling Liang, Zunayet Karim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0900792"}], "href": "https://doi.org/10.4049/jimmunol.0900792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19592652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19592652"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Magdalena M Gorska, Nicolas Goplen, Qiaoling Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0903115"}], "href": "https://doi.org/10.4049/jimmunol.0903115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20220094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20220094"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Magdalena M Gorska, Rafeul Alam "}, {"type": "b", "children": [{"type": "t", "text": "Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Allergy Asthma Rep (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11882-012-0281-4"}], "href": "https://doi.org/10.1007/s11882-012-0281-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22729960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22729960"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "YuKyung Lee, Sunglan Chung, In Keol Baek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC119a bridges the transmission of Fyn signals to Rab11, leading to the completion of cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.24404"}], "href": "https://doi.org/10.4161/cc.24404"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23535298"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23535298"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zunayet Karim, Ramarao Vepachedu, Magdalena Gorska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 inhibits dynamin and dynamin-dependent endocytic processes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2009.09.022"}], "href": "https://doi.org/10.1016/j.cellsig.2009.09.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19781630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19781630"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Antonios D Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00116-3"}], "href": "https://doi.org/10.1038/s41467-017-00116-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28740133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28740133"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Zhihong Liu, Youfu Zhang, Zhidan Xu "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β-catenin and TGF-β/EMT signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29552781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29552781"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Zhihong Liu, Youfu Zhang, Zhidan Xu "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 promotes the growth and migration of hepatocellular carcinoma via Wnt/β/catenin and TGF/β-EMT signaling pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29552782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29552782"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hiroaki Iwasa, Aradhan Sarkar, Takanobu Shimizu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 is a binding partner of tumor suppressor Ras-association domain family 6 and induces apoptosis and cell cycle arrest by MDM2 and p53."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.13706"}], "href": "https://doi.org/10.1111/cas.13706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29931788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29931788"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Zhi Hong Liu, You-Fu Zhang, Zhi-Dan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC119 promoted cell growth and migration by Wnt/β-catenin signal and TGF-β/EMT signal pathway in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J BUON (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30610799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30610799"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Zhenjiang Zhao, Anshoo Malhotra, Wu Yuan Seng "}, {"type": "b", "children": [{"type": "t", "text": "Curcumin Modulates Hepatocellular Carcinoma by Reducing UNC119 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Environ Pathol Toxicol Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1615/JEnvironPatholToxicolOncol.2019029549"}], "href": "https://doi.org/10.1615/JEnvironPatholToxicolOncol.2019029549"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31679307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31679307"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Takanobu Shimizu, Takeshi Nakamura, Hironori Inaba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RAS-interacting chaperone UNC119 drives the RASSF6-MDM2-p53 axis and antagonizes RAS-mediated malignant transformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA120.012649"}], "href": "https://doi.org/10.1074/jbc.RA120.012649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32554467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32554467"}]}]}]}
Synonyms	IMD13, POC7, POC7A
Proteins	U119A_HUMAN
NCBI Gene ID	9094
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UNC119 has 6,804 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 115 datasets.

Click the + buttons to view associations for UNC119 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UNC119 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC119 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC119 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UNC119 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UNC119 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UNC119 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC119 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UNC119 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UNC119 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UNC119 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UNC119 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UNC119 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UNC119 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UNC119 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UNC119 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UNC119 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UNC119 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UNC119 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with UNC119 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with UNC119 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UNC119 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UNC119 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UNC119 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UNC119 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UNC119 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UNC119 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UNC119 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with UNC119 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of UNC119 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UNC119 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving UNC119 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving UNC119 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UNC119 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UNC119 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UNC119 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UNC119 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UNC119 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UNC119 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UNC119 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UNC119 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UNC119 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.