UNC45A Gene

Name	unc-45 homolog A (C. elegans)
Description	This gene encodes a regulatory component of the progesterone receptor/heat shock protein 90 chaperoning complex, which functions in the assembly and folding of the progesterone receptor. The encoded protein is thought to be essential for normal cell proliferation, and for the accumulation of myosin during development of muscle cells. [provided by RefSeq, Sep 2018]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUNC45A functions as an essential co‐chaperone within the Hsp90 pathway, where it modulates the activation and chaperoning of specific client proteins such as the progesterone receptor. In this context, UNC45A (also referred to as GCUNC-45) binds directly to the ATP‐binding domain of Hsp90 to restrict cochaperone-induced ATPase activation, thereby fine-tuning receptor folding and activation. Moreover, this interaction displays isoform selectivity, with a preferential association for the Hsp90β isoform, emphasizing its specialized regulatory role in steroid receptor signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in steroid receptor regulation, UNC45A acts as a molecular chaperone for non-muscle myosins. It is critical for the proper folding of non-muscle myosin II, thereby facilitating the assembly of contractile actomyosin bundles such as stress fibers, which are vital for cell morphology, adhesion, and motility. In immune as well as neuronal cells, UNC45A supports the formation and dynamic turnover of cytoskeletal structures required for processes like natural killer cell granule exocytosis and growth cone-driven neurite elongation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUNC45A also contributes to oncogenesis by promoting tumor cell proliferation, invasion, and metastasis. Elevated levels of UNC45A have been documented in ovarian and breast carcinomas, where its chaperone activity supports not only actomyosin complex formation but also additional functions such as facilitating the transcriptional activation of key mitotic regulators (for example, via glucocorticoid receptor-NEK7 signaling) and ensuring proper centrosomal dynamics. These combined activities enhance cancer cell proliferation and enable invasive behaviors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its classical role in myosin folding, UNC45A interacts directly with microtubules, where it functions as an ATP-independent destabilizer of the microtubule lattice. This activity influences mitotic spindle dynamics, contributing to proper chromosome congression and segregation. Moreover, studies in yeast highlight an evolutionarily conserved function of the general cell isoform of UNC45 (UNC45-GC) in supporting Hsp90-mediated myosin head folding, underscoring the dual capacity of UNC45A to regulate both actomyosin and microtubule systems."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUNC45A is further indispensable for epithelial morphogenesis. By serving as a chaperone for myosin Vb, UNC45A ensures proper folding of this unconventional myosin, which is crucial for the organization of apical microvilli and the establishment of functional epithelial barriers. Defects in UNC45A consequently lead to impaired lumen formation, mislocalization of apical proteins, and disruptions in barrier integrity, as evidenced in both in vitro models and patient-derived tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, mutations that compromise UNC45A function have been linked to rare congenital disorders. Biallelic loss-of-function variants in the UNC45A gene are associated with a multisystem disorder characterized by cholestasis, congenital diarrhea, deafness, and bone fragility. In a related context, aberrant UNC45A activity is implicated in syndromes such as Aagenaes syndrome, highlighting the wide-ranging developmental and physiological consequences that emerge from disrupted chaperone activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ahmed Chadli, J Dinny Graham, M Greg Abel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.5.1722-1730.2006"}], "href": "https://doi.org/10.1128/MCB.26.5.1722-1730.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16478993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16478993"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ahmed Chadli, Sara J Felts, David O Toft "}, {"type": "b", "children": [{"type": "t", "text": "GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C800017200"}], "href": "https://doi.org/10.1074/jbc.C800017200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18285346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18285346"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jaakko I Lehtimäki, Aidan M Fenix, Tommi M Kotila, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC-45a promotes myosin folding and stress fiber assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201703107"}], "href": "https://doi.org/10.1083/jcb.201703107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29055011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29055011"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yoshie Iizuka, Frank Cichocki, Andrew Sieben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC-45A Is a Nonmuscle Myosin IIA Chaperone Required for NK Cell Cytotoxicity via Control of Lytic Granule Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1500979"}], "href": "https://doi.org/10.4049/jimmunol.1500979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26438524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26438524"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yoshie Iizuka, Ashley Mooneyham, Andrew Sieben, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC-45A is required for neurite extension via controlling NMII activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E16-06-0381"}], "href": "https://doi.org/10.1091/mbc.E16-06-0381"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28356421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28356421"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Martina Bazzaro, Antonio Santillan, Zhenhua Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin II co-chaperone general cell UNC-45 overexpression is associated with ovarian cancer, rapid proliferation, and motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2007.070325"}], "href": "https://doi.org/10.2353/ajpath.2007.070325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17872978"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17872978"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nada H Eisa, Yasmeen Jilani, Kashish Kainth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The co-chaperone UNC45A is essential for the expression of mitotic kinase NEK7 and tumorigenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.006597"}], "href": "https://doi.org/10.1074/jbc.RA118.006597"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30737284"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30737284"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wei Guo, Daisi Chen, Zhen Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential turnover of myosin chaperone UNC-45A isoforms increases in metastatic human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2011.07.012"}], "href": "https://doi.org/10.1016/j.jmb.2011.07.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21802425"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21802425"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yasmeen Jilani, Su Lu, Huang Lei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC45A localizes to centrosomes and regulates cancer cell proliferation through ChK1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2014.11.009"}], "href": "https://doi.org/10.1016/j.canlet.2014.11.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25444911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25444911"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Ashley Mooneyham, Yoshie Iizuka, Qing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-18-0670"}], "href": "https://doi.org/10.1158/1541-7786.MCR-18-0670"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30322860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30322860"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Juri Habicht, Ashley Mooneyham, Asumi Hoshino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC-45A breaks the microtubule lattice independently of its effects on non-muscle myosin II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.248815"}], "href": "https://doi.org/10.1242/jcs.248815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33262310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33262310"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Susana Gómez Escalante, Joseph A Brightmore, Peter W Piper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UCS protein function is partially restored in the Saccharomyces cerevisiae she4 mutant with expression of the human UNC45-GC, but not UNC45-SM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stress Chaperones (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12192-017-0870-1"}], "href": "https://doi.org/10.1007/s12192-017-0870-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29288355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29288355"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UNC45A deficiency causes microvillus inclusion disease-like phenotype by impairing myosin VB-dependent apical trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI154997"}], "href": "https://doi.org/10.1172/JCI154997"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35575086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35575086"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Qinghong Li, Zhe Zhou, Yue Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Functional Relationship Between UNC45A and MYO5B Connects Two Rare Diseases With Shared Enteropathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Gastroenterol Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jcmgh.2022.04.006"}], "href": "https://doi.org/10.1016/j.jcmgh.2022.04.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35421597"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35421597"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Susana Lechuga, Alexander X Cartagena-Rivera, Afshin Khan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200154R"}], "href": "https://doi.org/10.1096/fj.202200154R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35344227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35344227"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Clothilde Esteve, Ludmila Francescatto, Perciliz L Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss-of-Function Mutations in UNC45A Cause a Syndrome Associating Cholestasis, Diarrhea, Impaired Hearing, and Bone Fragility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2018.01.009"}], "href": "https://doi.org/10.1016/j.ajhg.2018.01.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29429573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29429573"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Runar Almaas, Monica Atneosen-Åsegg, Mari Eknes Ytre-Arne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aagenaes syndrome/lymphedema cholestasis syndrome 1 is caused by a founder variant in the 5'-untranslated region of UNC45A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2023.05.037"}], "href": "https://doi.org/10.1016/j.jhep.2023.05.037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37328071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37328071"}]}]}]}
Synonyms	SMAP1, IRO039700, GCUNC-45, GCUNC45, GC-UNC45, UNC-45A
Proteins	UN45A_HUMAN
NCBI Gene ID	55898
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UNC45A has 7,538 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for UNC45A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UNC45A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC45A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC45A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UNC45A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UNC45A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UNC45A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UNC45A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UNC45A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UNC45A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UNC45A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UNC45A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UNC45A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UNC45A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UNC45A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with UNC45A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UNC45A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UNC45A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UNC45A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing UNC45A protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UNC45A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UNC45A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UNC45A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UNC45A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UNC45A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UNC45A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UNC45A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UNC45A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UNC45A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UNC45A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UNC45A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UNC45A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with UNC45A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UNC45A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UNC45A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UNC45A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UNC45A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UNC45A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UNC45A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UNC45A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing UNC45A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of UNC45A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.