UPF3B Gene

HGNC Family	X-linked mental retardation
Name	UPF3 regulator of nonsense transcripts homolog B (yeast)
Description	This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUPF3B is a central mediator of nonsense‐mediated mRNA decay (NMD), a quality‐control pathway that eliminates transcripts harboring premature termination codons. It is recruited to spliced mRNAs approximately 20 nucleotides upstream of exon–exon junctions as part of the exon junction complex (EJC) and functions as a molecular bridge that links the EJC to the core NMD factors UPF2 and UPF1. Various structural studies have delineated distinct domains in UPF3B that mediate its binding to EJC proteins such as Y14, MAGOH, and eIF4AIII, and these interactions are critical for stimulating UPF1’s ATPase and RNA helicase activities, which in turn drive efficient mRNA surveillance and degradation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in complex assembly, UPF3B directly impacts translation termination. It interacts with the ribosome’s release factors and delays termination, thereby linking the process of translation with the activation of NMD. Although UPF3B shuttles between the nucleus and cytoplasm and binds to newly spliced mRNAs before export, its mRNA decay function is executed exclusively in the cytoplasm, where it collaborates with additional co‐factors to ensure the prompt removal of aberrant transcripts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDefects in UPF3B underlie a spectrum of human disorders. Loss‐of‐function mutations, often resulting in truncated protein products or decreased mRNA levels, have been directly linked to intellectual disability, autism spectrum disorders, and various neurodevelopmental syndromes. In neuronal cells, impaired UPF3B activity disrupts the regulation of mRNAs that control synaptic function and dendritic spine formation, while compensatory adjustments involving its paralog, UPF3A, modulate overall NMD efficacy. Moreover, aberrant UPF3B expression has been associated with pathological conditions in other tissues, such as cardiomyopathy and certain cancers, where it influences tissue‐specific gene expression programs via misregulated mRNA turnover."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "24"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "V N Kim, N Kataoka, G Dreyfuss "}, {"type": "b", "children": [{"type": "t", "text": "Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1062829"}], "href": "https://doi.org/10.1126/science.1062829"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11546873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11546873"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "J Lykke-Andersen, M D Shu, J A Steitz "}, {"type": "b", "children": [{"type": "t", "text": "Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1062786"}], "href": "https://doi.org/10.1126/science.1062786"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11546874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11546874"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Niels H Gehring, Gabriele Neu-Yilik, Thomas Schell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Y14 and hUpf3b form an NMD-activating complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(03)00142-4"}], "href": "https://doi.org/10.1016/s1097-2765(03"}, {"type": "t", "text": "00142-4) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12718880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12718880"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joachim B Kunz, Gabriele Neu-Yilik, Matthias W Hentze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1261/rna.12506"}], "href": "https://doi.org/10.1261/rna.12506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16601204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16601204"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hala Chamieh, Lionel Ballut, Fabien Bonneau, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1330"}], "href": "https://doi.org/10.1038/nsmb1330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18066079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18066079"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Gretel Buchwald, Judith Ebert, Claire Basquin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1000993107"}], "href": "https://doi.org/10.1073/pnas.1000993107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20479275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20479275"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Joshua C Bufton, Kyle T Powers, Jenn-Yeu A Szeto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkac421"}], "href": "https://doi.org/10.1093/nar/gkac421"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35640974"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35640974"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shihua Lu, Bryan R Cullen "}, {"type": "b", "children": [{"type": "t", "text": "Nonsense mediated decay induced by tethered human UPF3B is restricted to the cytoplasm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2004)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17194930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17194930"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Gabriele Neu-Yilik, Etienne Raimondeau, Boris Eliseev, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ICE1 promotes the link between splicing and nonsense-mediated mRNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.33178"}], "href": "https://doi.org/10.7554/eLife.33178"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29528287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29528287"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Patrick S Tarpey, F Lucy Raymond, Lam S Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng2100"}], "href": "https://doi.org/10.1038/ng2100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17704778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17704778"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "F Laumonnier, C Shoubridge, C Antar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2009.14"}], "href": "https://doi.org/10.1038/mp.2009.14"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19238151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19238151"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wai-Kin Chan, Angela D Bhalla, Hervé Le Hir, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A UPF3-mediated regulatory switch that maintains RNA surveillance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1612"}], "href": "https://doi.org/10.1038/nsmb.1612"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19503078"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19503078"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "L S Nguyen, L Jolly, C Shoubridge, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Broadening the phenotype associated with mutations in UPF3B: two further cases with renal dysplasia and variable developmental delay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2012.03.010"}], "href": "https://doi.org/10.1016/j.ejmg.2012.03.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22609145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22609145"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "X Xu, L Zhang, P Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exome sequencing identifies UPF3B as the causative gene for a Chinese non-syndrome mental retardation pedigree."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12014"}], "href": "https://doi.org/10.1111/cge.12014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22957832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22957832"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Tahani Alrahbeni, Francesca Sartor, Jihan Anderson, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2023.09.008"}], "href": "https://doi.org/10.1016/j.yjmcc.2023.09.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37797718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37797718"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Bowen Hou, Min Shu, Chenghao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Unveiling the role of UPF3B in hepatocellular carcinoma: Potential therapeutic target."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.16240"}], "href": "https://doi.org/10.1111/cas.16240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38889220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38889220"}]}]}]}
Synonyms	MRX62, MRXS14, Upf3p-X, UPF3BP2, UPF3BP3, HUPF3B, UPF3X, UPF3BP1, RENT3B
Proteins	REN3B_HUMAN
NCBI Gene ID	65109
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

UPF3B has 6,398 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 118 datasets.

Click the + buttons to view associations for UPF3B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

UPF3B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UPF3B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of UPF3B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of UPF3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of UPF3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of UPF3B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of UPF3B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of UPF3B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of UPF3B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of UPF3B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of UPF3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of UPF3B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with UPF3B protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UPF3B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of UPF3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of UPF3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with UPF3B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with UPF3B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of UPF3B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of UPF3B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing UPF3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing UPF3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing UPF3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing UPF3B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with UPF3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with UPF3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing UPF3B protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of UPF3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with UPF3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with UPF3B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with UPF3B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by UPF3B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving UPF3B gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving UPF3B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with UPF3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with UPF3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with UPF3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with UPF3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at UPF3B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of UPF3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of UPF3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.