URI1 Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	URI1, prefoldin-like chaperone
Description	This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nURI1, also known as the unconventional prefoldin RPB5 interactor (or RMP), is emerging as a multifaceted regulator linking nutrient sensing and transcriptional control. Fundamental studies revealed that URI1 is a target of nutrient signaling pathways—most notably controlled by the TOR kinase—and functions as part of a prefoldin complex that coordinates gene expression in response to cellular metabolic status."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nURI1 also plays an important role in modulating mitochondrial survival signaling and apoptotic thresholds. It is phosphorylated by S6 kinase 1 (S6K1) under growth factor stimulation, which leads to the disassembly of its complex with protein phosphatase PP1γ—a key step that sets the mitochondrial threshold for apoptosis. In addition, URI1 acts as a transcriptional coregulator by interacting with proteins such as Art-27 to repress androgen receptor–mediated transcription, while simultaneously sustaining oncogenic survival signals in several cancer contexts, including ovarian cancer and multiple myeloma. Amplification of URI1 has been linked to aggressive tumor behavior, and its depletion in certain colorectal cancer models triggers p53-dependent cell death."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, URI1 contributes to tumorigenesis and treatment resistance through several additional mechanisms. In hepatocellular carcinoma (HCC), for instance, URI1 disrupts aryl hydrocarbon and estrogen receptor-mediated transcription of metabolic enzymes involved in L-tryptophan degradation, leading to DNA damage at early tumorigenic stages. In parallel, URI1 regulates c-MYC levels via control of O-GlcNAc transferase (OGT) in response to glucose availability, while its overexpression promotes epithelial–mesenchymal transition (EMT) through activation of the NF‐κB/CSN2/Snail axis. URI1 expression is further enhanced in HBV‐related HCC by the combined action of viral HBx protein and c‐MYC, and high levels of URI1 can even mediate resistance to irradiation by activating autophagy through an AMPK/FOXO3 pathway. In endometrial cancers and high‐grade tumors, gene amplification of URI1 is associated with aggressive disease features."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Matthias Gstaiger, Brian Luke, Daniel Hess, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1088401"}], "href": "https://doi.org/10.1126/science.1088401"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14615539"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14615539"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Krishna S Tummala, Ana L Gomes, Mahmut Yilmaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2014.10.002"}], "href": "https://doi.org/10.1016/j.ccell.2014.10.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25453901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25453901"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Stefan Burén, Ana L Gomes, Ana Teijeiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.06.023"}], "href": "https://doi.org/10.1016/j.ccell.2016.06.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27505673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27505673"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Nabil Djouder, Stefan Christian Metzler, Alexander Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2007.08.010"}], "href": "https://doi.org/10.1016/j.molcel.2007.08.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17936702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17936702"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Min He, Jiyang Cai, Young-Mi Go, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/toxsci/kfn116"}], "href": "https://doi.org/10.1093/toxsci/kfn116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18550601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18550601"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jean-Philippe Theurillat, Stefan Christian Metzler, Nico Henzi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "URI is an oncogene amplified in ovarian cancer cells and is required for their survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2011.01.019"}], "href": "https://doi.org/10.1016/j.ccr.2011.01.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21397856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21397856"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J-L Fan, J Zhang, L-W Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "URI regulates tumorigenicity and chemotherapeutic resistance of multiple myeloma by modulating IL-6 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.93"}], "href": "https://doi.org/10.1038/cddis.2014.93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24625985"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24625985"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Aurelia Noske, Leigh A Henricksen, Bonnie LaFleur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the 19q12 amplification including CCNE1 and URI in different epithelial ovarian cancer subtypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Mol Pathol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexmp.2014.12.004"}], "href": "https://doi.org/10.1016/j.yexmp.2014.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25527175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25527175"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jian Zhang, Tian-Yi Jiang, Bei-Ge Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3092"}], "href": "https://doi.org/10.18632/oncotarget.3092"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25605019"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25605019"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Kamil Andrzej Lipinski, Christian Britschgi, Karen Schrader, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Colorectal cancer cells display chaperone dependency for the unconventional prefoldin URI1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.8816"}], "href": "https://doi.org/10.18632/oncotarget.8816"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27105489"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27105489"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Aurelia Noske, Simone Brandt, Nadejda Valtcheva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.11605"}], "href": "https://doi.org/10.18632/oncotarget.11605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27582547"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27582547"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wei Zhou, Qi Wang, Yi Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RMP promotes epithelial-mesenchymal transition through NF-κB/CSN2/Snail pathway in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16177"}], "href": "https://doi.org/10.18632/oncotarget.16177"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28423737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28423737"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hiroyuki Tsuchiya, Masataka Amisaki, Ai Takenaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBx and c-MYC Cooperate to Induce URI1 Expression in HBV-Related Hepatocellular Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20225714"}], "href": "https://doi.org/10.3390/ijms20225714"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31739577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31739577"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Yanrui Huang, Jenny H Zhou, Haifeng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI148852"}], "href": "https://doi.org/10.1172/JCI148852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35202005"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35202005"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhi-Xing Wei, Xing-Xing Cai, Yu-Dong Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-024-05125-2"}], "href": "https://doi.org/10.1007/s00018-024-05125-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38349408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38349408"}]}]}]}
Synonyms	PPP1R19, C19ORF2, URI
Proteins	RMP_HUMAN
NCBI Gene ID	8725
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

URI1 has 6,244 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.

Click the + buttons to view associations for URI1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

URI1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by URI1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of URI1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of URI1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of URI1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of URI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of URI1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of URI1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of URI1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of URI1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of URI1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of URI1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of URI1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of URI1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with URI1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with URI1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of URI1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of URI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of URI1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of URI1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing URI1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of URI1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing URI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing URI1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing URI1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with URI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with URI1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing URI1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of URI1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with URI1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with URI1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving URI1 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving URI1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with URI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with URI1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with URI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with URI1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at URI1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of URI1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of URI1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing URI1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.