USP17L6P Gene

Name ubiquitin specific peptidase 17-like family member 6, pseudogene
Description Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination involved in ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Mar 2025]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the abstract from PubMed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "focuses on Fragile X syndrome and delineates how the Fragile X Mental Retardation Protein (FMRP) regulates local translation of key synaptic proteins via control of diacylglycerol kinase kappa (Dgkκ), there is no mention or functional description provided for USP17L6P. Rather, this work underscores the dysregulation of lipid signaling and synaptic protein synthesis in the absence of FMRP.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSimilarly, the abstract from PubMed"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "explores the inflammatory processes driving sepsis-induced acute lung injury with particular attention to T cell-derived extracellular vesicles. This study does not address USP17L6P, leaving its potential role in these immune mechanisms uncharacterized within the reported findings.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn summary, based on the provided abstracts, USP17L6P does not have an assigned or described function in the context of either synaptic protein regulation in Fragile X syndrome or the inflammatory cascades associated with sepsis. Further investigations would be required to elucidate any involvement of USP17L6P in these or related biological processes.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ricardos Tabet, Enora Moutin, Jérôme A J Becker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1522631113"}], "href": "https://doi.org/10.1073/pnas.1522631113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27233938"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27233938"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guo-Wei Tu, Yi Zhang, Jie-Fei Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular vesicles derived from CD4"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Biol Lett (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s11658-023-00435-y"}], "href": "https://doi.org/10.1186/s11658-023-00435-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36959535"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36959535"}]}]}]}
Synonyms DUB4, USP17L6, VDUB4
Proteins U17L6_HUMAN
NCBI Gene ID 391622
API
Download Associations
Predicted Functions View USP17L6P's ARCHS4 Predicted Functions.
Co-expressed Genes View USP17L6P's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View USP17L6P's ARCHS4 Predicted Functions.

Functional Associations

USP17L6P has 331 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for USP17L6P from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L6P gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing USP17L6P protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L6P gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at USP17L6P gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of USP17L6P gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of USP17L6P gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of USP17L6P gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of USP17L6P gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GO Biological Process Annotations 2023 biological processes involving USP17L6P gene from the curated GO Biological Process Annotations 2023 dataset.
GO Cellular Component Annotations 2023 cellular components containing USP17L6P protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by USP17L6P gene from the curated GO Molecular Function Annotations 2023 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of USP17L6P gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of USP17L6P gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of USP17L6P gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of USP17L6P gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.