USP7 Gene

HGNC Family Ubiquitin-specific peptidases (USP)
Name ubiquitin specific peptidase 7 (herpes virus-associated)
Description The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nUSP7, also known as HAUSP, is a critical deubiquitinating enzyme that modulates the stability and activity of key tumor suppressor and oncogenic proteins. It directly deubiquitinates p53—and, via regulation of its negative regulators such as Mdm2 and Hdmx—plays a central role in controlling cell‐cycle arrest and apoptosis. USP7 also binds viral proteins (for example, Epstein–Barr virus EBNA1 and herpes simplex virus ICP0) to perturb p53 regulation and thereby influence viral persistence and tumorigenesis. In addition, USP7 stabilizes oncogenic drivers like N‐Myc and has been implicated in aberrant reproductive and cancer outcomes, with its expression further modulated by epitranscriptomic regulators in lung cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in tumor suppression and viral pathogenesis, USP7 contributes to the regulation of chromatin structure and the DNA damage response. It deubiquitinates epigenetic regulators such as PHF8, DNMT1, and UHRF1—and stabilizes the DNA damage‐sensing protein XPC—thereby maintaining proper histone modification patterns, transcriptional repression (via Polycomb complexes), and genomic integrity. USP7 also regulates the stability of other ubiquitin ligases like MARCH7, underscoring its broader role in protein homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nUSP7 further integrates and fine‐tunes key signaling pathways and immune responses. By coordinating with complexes such as the MAGE–TRIM27 ligase, it regulates endosomal recycling and actin dynamics; it modulates inflammasome activation by controlling the ubiquitination status of key components; and it enhances NF‑κB–dependent transcription by deubiquitinating its signaling intermediates. Moreover, USP7 promotes canonical Wnt signaling through deubiquitination of beta‑catenin and its cooperation with E3 ligases like RNF220, while its altered activity in immune cells impacts macrophage polarization and inflammatory mediator production. Collectively, these functions underscore the therapeutic potential of USP7 inhibition in cancers and inflammatory disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Muyang Li, Delin Chen, Ariel Shiloh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature737"}], "href": "https://doi.org/10.1038/nature737"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11923872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11923872"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Muyang Li, Christopher L Brooks, Ning Kon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A dynamic role of HAUSP in the p53-Mdm2 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1097-2765(04)00157-1"}], "href": "https://doi.org/10.1016/s1097-2765(04"}, {"type": "t", "text": "00157-1) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15053880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15053880"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Vivian Saridakis, Yi Sheng, Feroz Sarkari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.02.029"}], "href": "https://doi.org/10.1016/j.molcel.2005.02.029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15808506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15808506"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi Sheng, Vivian Saridakis, Feroz Sarkari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular recognition of p53 and MDM2 by USP7/HAUSP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb1067"}], "href": "https://doi.org/10.1038/nsmb1067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16474402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16474402"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Erik Meulmeester, Madelon M Maurice, Chris Boutell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2005.04.024"}], "href": "https://doi.org/10.1016/j.molcel.2005.04.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15916963"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15916963"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Benjamin Nicholson, K G Suresh Kumar "}, {"type": "b", "children": [{"type": "t", "text": "The multifaceted roles of USP7: new therapeutic opportunities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biochem Biophys (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12013-011-9185-5"}], "href": "https://doi.org/10.1007/s12013-011-9185-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21468693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21468693"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alex C Faesen, Annette M G Dirac, Anitha Shanmugham, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.06.034"}], "href": "https://doi.org/10.1016/j.molcel.2011.06.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21981925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21981925"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jie Li, Yi Han, Hongmei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.03.093"}], "href": "https://doi.org/10.1016/j.bbrc.2019.03.093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30905413"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30905413"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Omid Tavana, Dawei Li, Chao Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4180"}], "href": "https://doi.org/10.1038/nm.4180"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27618649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27618649"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Hey-Joo Kang, Zhaohui Feng, Yvonne Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0904280106"}], "href": "https://doi.org/10.1073/pnas.0904280106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19470478"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19470478"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Melissa N Holowaty, Yi Sheng, Tin Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307200200"}], "href": "https://doi.org/10.1074/jbc.M307200200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14506283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14506283"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Qian Wang, Shuai Ma, Nan Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stabilization of histone demethylase PHF8 by USP7 promotes breast carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI85747"}], "href": "https://doi.org/10.1172/JCI85747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27183383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27183383"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Goedele N Maertens, Selma El Messaoudi-Aubert, Sarah Elderkin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.129"}], "href": "https://doi.org/10.1038/emboj.2010.129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20601937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20601937"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Weihua Qin, Heinrich Leonhardt, Fabio Spada "}, {"type": "b", "children": [{"type": "t", "text": "Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22998"}], "href": "https://doi.org/10.1002/jcb.22998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21268065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21268065"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zhi Huang, Qiulian Wu, Olga A Guryanova, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitylase HAUSP stabilizes REST and promotes maintenance of neural progenitor cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2153"}], "href": "https://doi.org/10.1038/ncb2153"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21258371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21258371"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jinshan He, Qianzheng Zhu, Gulzar Wani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.589812"}], "href": "https://doi.org/10.1074/jbc.M114.589812"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25118285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25118285"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dongxue Su, Shuai Ma, Lin Shan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI120518"}], "href": "https://doi.org/10.1172/JCI120518"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30179224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30179224"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "James A Nathan, Soma Sengupta, Stephen A Wood, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0854.2008.00747.x"}], "href": "https://doi.org/10.1111/j.1600-0854.2008.00747.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18410486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18410486"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yi-Heng Hao, Michael D Fountain, Klementina Fon Tacer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2015.07.033"}], "href": "https://doi.org/10.1016/j.molcel.2015.07.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26365382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26365382"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xiaomeng Dai, Lisen Lu, Suke Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7 targeting modulates anti-tumor immune response by reprogramming Tumor-associated Macrophages in Lung Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.47137"}], "href": "https://doi.org/10.7150/thno.47137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32802195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32802195"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Pablo Palazón-Riquelme, Jonathan D Worboys, Jack Green, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201744766"}], "href": "https://doi.org/10.15252/embr.201744766"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30206189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30206189"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nirojini Sivachandran, Feroz Sarkari, Lori Frappier "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr nuclear antigen 1 contributes to nasopharyngeal carcinoma through disruption of PML nuclear bodies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Pathog (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.ppat.1000170"}], "href": "https://doi.org/10.1371/journal.ppat.1000170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18833293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18833293"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Amy Colleran, Patricia E Collins, Christine O'Carroll, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitination of NF-κB by Ubiquitin-Specific Protease-7 promotes transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1208446110"}], "href": "https://doi.org/10.1073/pnas.1208446110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23267096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23267096"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Svetlana V Khoronenkova, Irina I Dianova, Nicola Ternette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2012.01.021"}], "href": "https://doi.org/10.1016/j.molcel.2012.01.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22361354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22361354"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Laura Novellasdemunt, Valentina Foglizzo, Laura Cuadrado, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.09.072"}], "href": "https://doi.org/10.1016/j.celrep.2017.09.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29045831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29045831"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Sandrine Daubeuf, Divyendu Singh, Yaohong Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HSV ICP0 recruits USP7 to modulate TLR-mediated innate response."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-07-168203"}], "href": "https://doi.org/10.1182/blood-2008-07-168203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18952891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18952891"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Dingding Shi, Steven R Grossman "}, {"type": "b", "children": [{"type": "t", "text": "Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.10.8.13417"}], "href": "https://doi.org/10.4161/cbt.10.8.13417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20930542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20930542"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Marta Derecka, Agnieszka Gornicka, Sergei B Koralov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cmet.2012.11.005"}], "href": "https://doi.org/10.1016/j.cmet.2012.11.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23217260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23217260"}]}]}]}
Synonyms HAUSP, TEF1
Proteins UBP7_HUMAN
NCBI Gene ID 7874
API
Download Associations
Predicted Functions View USP7's ARCHS4 Predicted Functions.
Co-expressed Genes View USP7's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View USP7's ARCHS4 Predicted Functions.

Functional Associations

USP7 has 10,757 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 132 datasets.

Click the + buttons to view associations for USP7 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by USP7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of USP7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of USP7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of USP7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of USP7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of USP7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of USP7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of USP7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
Carcinogenome Chemical Perturbation Carcinogenicity Signatures small molecule perturbations changing expression of USP7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of USP7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with USP7 protein from the CCLE Cell Line Proteomics dataset.
CellMarker Gene-Cell Type Associations cell types associated with USP7 gene from the CellMarker Gene-Cell Type Associations dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of USP7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of USP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of USP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
ClinVar Gene-Phenotype Associations 2025 phenotypes associated with USP7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
CM4AI U2OS Cell Map Protein Localization Assemblies assemblies containing USP7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of USP7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing USP7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing USP7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 cellular components containing USP7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with USP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with USP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of USP7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with USP7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Chemical Interactions chemicals interacting with USP7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
CTD Gene-Disease Associations diseases associated with USP7 gene/protein from the curated CTD Gene-Disease Associations dataset.
DISEASES Curated Gene-Disease Association Evidence Scores 2025 diseases involving USP7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 diseases associated with USP7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with USP7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with USP7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with USP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with USP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at USP7 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of USP7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of USP7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing USP7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with USP7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GAD High Level Gene-Disease Associations diseases associated with USP7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with USP7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing USP7 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of USP7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving USP7 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving USP7 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving USP7 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing USP7 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing USP7 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing USP7 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by USP7 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by USP7 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by USP7 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx eQTL 2025 SNPs regulating expression of USP7 gene from the GTEx eQTL 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of USP7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of USP7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of USP7 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of USP7 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWAS Catalog SNP-Phenotype Associations 2025 phenotypes associated with USP7 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with USP7 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HMDB Metabolites of Enzymes interacting metabolites for USP7 protein from the curated HMDB Metabolites of Enzymes dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of USP7 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of USP7 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of USP7 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
HPM Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of USP7 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for USP7 from the curated Hub Proteins Protein-Protein Interactions dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with USP7 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for USP7 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of USP7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
JASPAR Predicted Mouse Transcription Factor Targets 2025 transcription factors regulating expression of USP7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of USP7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEA Substrates of Kinases kinases that phosphorylate USP7 protein from the curated KEA Substrates of Kinases dataset.
KEGG Pathways 2026 pathways involving USP7 protein from the KEGG Pathways 2026 dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of USP7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of USP7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with USP7 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of USP7 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of USP7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of USP7 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of USP7 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
LOCATE Curated Protein Localization Annotations cellular components containing USP7 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain USP7 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MGI Mouse Phenotype Associations 2023 phenotypes of transgenic mice caused by USP7 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset.
MiRTarBase microRNA Targets microRNAs targeting USP7 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of USP7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by USP7 gene mutations from the MPO Gene-Phenotype Associations dataset.
MSigDB Cancer Gene Co-expression Modules co-expressed genes for USP7 from the MSigDB Cancer Gene Co-expression Modules dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of USP7 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing USP7 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for USP7 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of USP7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of USP7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving USP7 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving USP7 protein from the Wikipathways PFOCR 2024 dataset.
Phosphosite Textmining Biological Term Annotations biological terms co-occuring with USP7 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.
PhosphoSitePlus Substrates of Kinases kinases that phosphorylate USP7 protein from the curated PhosphoSitePlus Substrates of Kinases dataset.
PID Pathways pathways involving USP7 protein from the PID Pathways dataset.
ProteomicsDB Cell Type and Tissue Protein Expression Profiles cell types and tissues with high or low expression of USP7 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset.
Reactome Pathways 2024 pathways involving USP7 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of USP7 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of USP7 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of USP7 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of USP7 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of USP7 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at USP7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of USP7 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of USP7 gene from the RummaGEO Gene Perturbation Signatures dataset.
Sanger Dependency Map Cancer Cell Line Proteomics cell lines associated with USP7 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset.
Sci-Plex Drug Perturbation Signatures drug perturbations changing expression of USP7 gene from the Sci-Plex Drug Perturbation Signatures dataset.
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands ligand (protein) perturbations changing phosphorylation of USP7 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Protein Ligands dataset.
Tahoe Therapeutics Tahoe 100M Perturbation Atlas drug perturbations changing expression of USP7 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of USP7 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of USP7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of USP7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of USP7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of USP7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of USP7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of USP7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with USP7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with USP7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
Virus MINT Protein-Viral Protein Interactions interacting viral proteins for USP7 from the Virus MINT Protein-Viral Protein Interactions dataset.
Virus MINT Protein-Virus Interactions viruses interacting with USP7 from the Virus MINT Protein-Virus Interactions dataset.
WikiPathways Pathways 2014 pathways involving USP7 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving USP7 protein from the WikiPathways Pathways 2024 dataset.