{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nRecent studies have underscored the importance of nucleolar proteins in diverse disease states. For instance, one investigation highlighted the altered expression and localization of the nucleolar phosphoprotein CGI‐94 in early Alzheimer’s disease, emphasizing that disruptions in nucleolar functions can be a hallmark of neurodegenerative processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast, UTP11, a nucleolar protein that is integral to the biosynthesis of 18S ribosomal RNA via its association with the pre‐rRNA processing factor MPP10, has emerged as a pivotal factor in cancer cell survival. Overexpression of UTP11 is correlated with poor prognoses in various human cancers, and its depletion not only impairs ribosome production causing nucleolar stress and subsequent p53‐mediated cell growth arrest but also induces p53‐independent ferroptotic cell death by diminishing glutathione levels through enhanced decay of NRF2 mRNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, accumulating evidence points to the potential involvement of UTP11 in the pathogenesis of hepatocellular carcinoma, although the biological mechanisms and clinical significance in this context are still not fully understood. These findings nominate UTP11 as a promising candidate for further investigations in liver cancer pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Klaus Heese, Takahiro Nakayama, Ryuji Hata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterizing CGI-94 (comparative gene identification-94) which is down-regulated in the hippocampus of early stage Alzheimer's disease brain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1046/j.0953-816x.2001.01836.x"}], "href": "https://doi.org/10.1046/j.0953-816x.2001.01836.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11860508"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11860508"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yu Gan, Jun Deng, Qian Hao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2023.102705"}], "href": "https://doi.org/10.1016/j.redox.2023.102705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37087976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37087976"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yan Chen, Xiaowei Zhang, Mingcheng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UTP11 promotes the growth of hepatocellular carcinoma by enhancing the mRNA stability of Oct4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-023-11794-2"}], "href": "https://doi.org/10.1186/s12885-023-11794-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38233795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38233795"}]}]}]}