| HGNC Family | Vesicle-associated membrane proteins (VAMP), Pseudoautosomal regions |
| Name | vesicle-associated membrane protein 7 |
| Description | This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVAMP7 is a highly conserved, longin‐domain–containing R‐SNARE that plays a pivotal role in mediating membrane fusion events. At the molecular level, structural and biochemical studies reveal that VAMP7 predominantly adopts a “closed” conformation that restricts SNARE complex assembly until relieved by regulatory inputs such as tyrosine phosphorylation and competitive interactions with adaptor proteins. Alternative mRNA splicing gives rise to distinct isoforms (for example, the VAMP7j variant) that can fine‐tune its activity during processes such as neurite outgrowth and synaptic development. These mechanistic insights—including roles in autophagosome–lysosome fusion and in the formation of amphisomes—underscore the central position of VAMP7 in trafficking and secretory pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn diverse secretory and immune cell types, VAMP7 is indispensable for the regulated exocytosis of critical cargos. In mast cells and natural killer cells, it governs the fusion of secretory lysosomes that release mediators and cytotoxic granules, thereby fine‐tuning responses such as degranulation and target cell killing. Moreover, in platelets and cytotoxic lymphocytes, VAMP7‐dependent membrane fusion is required not only for granule release but also for membrane remodelling during cell spreading and immunological synapse formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role in vesicle fusion, VAMP7 is a critical mediator in polarized epithelial trafficking, neuronal process formation, and even host–pathogen interactions. In neurons and epithelial cells, VAMP7 collaborates with a range of partners to promote apical cargo delivery, regulate neurite outgrowth and cell polarity, and target proteases such as MT1‐MMP to invadopodia—activities that underlie cancer cell invasion and metastasis. In addition, VAMP7 participates in the formation and maturation of pathogen‐containing vacuoles (as seen in Yersinia and Helicobacter infections) and in the sorting of melanocyte cargo to maturing organelles. Collectively, these studies support roles for VAMP7 in controlling cytoskeletal dynamics, endosomal–lysosomal fusion, and exosomal release as well as in modulating signal transduction pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "36"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, genetic and epigenetic investigations have implicated the SYBL1 gene—which encodes VAMP7—in neuropsychiatric disorders and congenital genitourinary anomalies. Analyses of the promoter and copy number of SYBL1 in patient samples not only reveal unusual patterns of X‐ and Y‐linked inactivation but also provide a basis for novel diagnostic approaches in early detection of sex chromosome aneuploidies and related developmental defects."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "37", "end_ref": "42"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Claudio Marcelo Fader, Diego Germán Sánchez, María Belén Mestre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2009.09.011"}], "href": "https://doi.org/10.1016/j.bbamcr.2009.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19781582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19781582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sandro Vivona, Corey W Liu, Pavel Strop, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The longin SNARE VAMP7/TI-VAMP adopts a closed conformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.120972"}], "href": "https://doi.org/10.1074/jbc.M110.120972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20378544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20378544"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marcella Vacca, Lara Albania, Floriana Della Ragione, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alternative splicing of the human gene SYBL1 modulates protein domain architecture of Longin VAMP7/TI-VAMP, showing both non-SNARE and synaptobrevin-like isoforms."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2199-12-26"}], "href": "https://doi.org/10.1186/1471-2199-12-26"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21609427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21609427"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maaike S Pols, Eline van Meel, Viola Oorschot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2360"}], "href": "https://doi.org/10.1038/ncomms2360"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23322049"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23322049"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Andrea Burgo, Alessandra M Casano, Aurelia Kuster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.415075"}], "href": "https://doi.org/10.1074/jbc.M112.415075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23471971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23471971"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xiaoyu Tian, Pengli Zheng, Chenqian Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2019.1637199"}], "href": "https://doi.org/10.1080/15548627.2019.1637199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31251111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31251111"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Matteo Gasparotto, Elena Dall'Ara, Marcella Vacca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP7j: A Splice Variant of Human VAMP7 That Modulates Neurite Outgrowth by Regulating L1CAM Transport to the Plasma Membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms242417326"}], "href": "https://doi.org/10.3390/ijms242417326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38139155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38139155"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Fenglei Jian, Shen Wang, Rui Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-023-00916-x"}], "href": "https://doi.org/10.1038/s41422-023-00916-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38182888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38182888"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marcelo Marcet-Palacios, Solomon O Odemuyiwa, Jason J Coughlin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vesicle-associated membrane protein 7 (VAMP-7) is essential for target cell killing in a natural killer cell line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.11.079"}], "href": "https://doi.org/10.1016/j.bbrc.2007.11.079"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18042464"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18042464"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Leif E Sander, Simon P C Frank, Seza Bolat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200737634"}], "href": "https://doi.org/10.1002/eji.200737634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18253931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18253931"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Konrad Krzewski, Aleksandra Gil-Krzewska, James Watts, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201141582"}], "href": "https://doi.org/10.1002/eji.201141582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21805468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21805468"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Christian G Peters, Alan D Michelson, Robert Flaumenhaft "}, {"type": "b", "children": [{"type": "t", "text": "Granule exocytosis is required for platelet spreading: differential sorting of α-granules expressing VAMP-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-10-389247"}], "href": "https://doi.org/10.1182/blood-2011-10-389247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22589474"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22589474"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Mounia Tannour-Louet, Shuo Han, Jean-Francois Louet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3580"}], "href": "https://doi.org/10.1038/nm.3580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24880616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24880616"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Praneeth Chitirala, Keerthana Ravichandran, Donatella Galgano, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cytotoxic Granule Exocytosis From Human Cytotoxic T Lymphocytes Is Mediated by VAMP7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2019.01855"}], "href": "https://doi.org/10.3389/fimmu.2019.01855"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31447853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31447853"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Stefan Sikorra, Tina Henke, Subramanyam Swaminathan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the amino acid residues rendering TI-VAMP insensitive toward botulinum neurotoxin B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmb.2005.12.075"}], "href": "https://doi.org/10.1016/j.jmb.2005.12.075"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16430921"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16430921"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Hirosato Mashima, Junko Suzuki, Toshiya Hirayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of vesicle-associated membrane protein 7 in human gastric epithelial cell vacuolation induced by Helicobacter pylori-produced VacA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Infect Immun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/IAI.01573-07"}], "href": "https://doi.org/10.1128/IAI.01573-07"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18362137"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18362137"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Anika Steffen, Gaëlle Le Dez, Renaud Poincloux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2008.05.044"}], "href": "https://doi.org/10.1016/j.cub.2008.05.044"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18571410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18571410"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Sarah E Flowerdew, Robert D Burgoyne "}, {"type": "b", "children": [{"type": "t", "text": "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20081736"}], "href": "https://doi.org/10.1042/BJ20081736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19138172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19138172"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Andrea Burgo, Emmanuel Sotirakis, Marie-Christine Simmler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2009.186"}], "href": "https://doi.org/10.1038/embor.2009.186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19745841"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19745841"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Karla C Williams, Marc G Coppolino "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of membrane type 1-matrix metalloproteinase (MT1-MMP) and its vesicle-associated membrane protein 7 (VAMP7)-dependent trafficking facilitate cell invasion and migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.297069"}], "href": "https://doi.org/10.1074/jbc.M111.297069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22002060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22002060"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Claudia Verderio, Cinzia Cagnoli, Matteo Bergami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TI-VAMP/VAMP7 is the SNARE of secretory lysosomes contributing to ATP secretion from astrocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/boc.201100070"}], "href": "https://doi.org/10.1111/boc.201100070"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22188132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22188132"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Lydia Danglot, Kathleen Zylbersztejn, Maja Petkovic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4436-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.4436-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22323709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22323709"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Claudio Marcelo Fader, Milton Osmar Aguilera, María Isabel Colombo "}, {"type": "b", "children": [{"type": "t", "text": "ATP is released from autophagic vesicles to the extracellular space in a VAMP7-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.21858"}], "href": "https://doi.org/10.4161/auto.21858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22951367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22951367"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Ingmar B Schäfer, Geoffrey G Hesketh, Nicholas A Bright, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The binding of Varp to VAMP7 traps VAMP7 in a closed, fusogenically inactive conformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.2414"}], "href": "https://doi.org/10.1038/nsmb.2414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23104059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23104059"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Emanuel Martín Campoy, María Eugenia Mansilla, María Isabel Colombo "}, {"type": "b", "children": [{"type": "t", "text": "Endocytic SNAREs are involved in optimal Coxiella burnetii vacuole development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Microbiol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cmi.12087"}], "href": "https://doi.org/10.1111/cmi.12087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23217169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23217169"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Daniela A Sahlender, Patrycja Kozik, Sharon E Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0064514"}], "href": "https://doi.org/10.1371/journal.pone.0064514"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23741335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23741335"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Karla C Williams, Rachael E McNeilly, Marc G Coppolino "}, {"type": "b", "children": [{"type": "t", "text": "SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-10-0582"}], "href": "https://doi.org/10.1091/mbc.E13-10-0582"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24807903"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24807903"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Laure-Anne Ligeon, Kevin Moreau, Nicolas Barois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of VAMP3 and VAMP7 in the commitment of Yersinia pseudotuberculosis to LC3-associated pathways involving single- or double-membrane vacuoles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.29411"}], "href": "https://doi.org/10.4161/auto.29411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25046114"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25046114"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Deivendran Rengaraj, Woo-Sung Kwon, Myung-Geol Pang "}, {"type": "b", "children": [{"type": "t", "text": "Bioinformatics Annotation of Human Y Chromosome-Encoded Protein Pathways and Interactions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.5b00491"}], "href": "https://doi.org/10.1021/acs.jproteome.5b00491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26279084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26279084"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Georg F Vogel, Katharina M C Klee, Andreas R Janecke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201506112"}], "href": "https://doi.org/10.1083/jcb.201506112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26553929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26553929"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "José Wojnacki, Sébastien Nola, Philippe Bun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of VAMP7-Dependent Secretion of Reticulon 3 in Neurite Growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2020.108536"}], "href": "https://doi.org/10.1016/j.celrep.2020.108536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33357422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33357422"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Shanna L Bowman, Linh Le, Yueyao Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A BLOC-1-AP-3 super-complex sorts a cis-SNARE complex into endosome-derived tubular transport carriers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202005173"}], "href": "https://doi.org/10.1083/jcb.202005173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33886957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33886957"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Luther J Davis, Nicholas A Bright, James R Edgar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.255463"}], "href": "https://doi.org/10.1242/jcs.255463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34042162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34042162"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Xueqiang Peng, Xinyu Li, Shuo Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00511 drives invasive behavior in hepatocellular carcinoma by regulating exosome secretion and invadopodia formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-021-01990-y"}], "href": "https://doi.org/10.1186/s13046-021-01990-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34088337"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34088337"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Dandan Li, Mengjie Xu, Zidi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The EMT-induced lncRNA NR2F1-AS1 positively modulates NR2F1 expression and drives gastric cancer via miR-29a-3p/VAMP7 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04540-2"}], "href": "https://doi.org/10.1038/s41419-022-04540-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35082283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35082283"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Yu Huang, Mei Wu, Jian-Di Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of vesicle-associated membrane protein 7 in breast cancer tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Health Care (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/THC-230832"}], "href": "https://doi.org/10.3233/THC-230832"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38393934"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38393934"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Daniel J Müller, Thomas G Schulze, Esther Jahnes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between a polymorphism in the pseudoautosomal X-linked gene SYBL1 and bipolar affective disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.10115"}], "href": "https://doi.org/10.1002/ajmg.10115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11840509"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11840509"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Maria Rosaria Matarazzo, Maria Luigia De Bonis, Richard I Gregory, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allelic inactivation of the pseudoautosomal gene SYBL1 is controlled by epigenetic mechanisms common to the X and Y chromosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/11.25.3191"}], "href": "https://doi.org/10.1093/hmg/11.25.3191"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12444103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12444103"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Francesca Di Leva, Maria Immacolata Ferrante, Francesca Demarchi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human synaptobrevin-like 1 gene basal transcription is regulated through the interaction of selenocysteine tRNA gene transcription activating factor-zinc finger 143 factors with evolutionary conserved cis-elements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M308140200"}], "href": "https://doi.org/10.1074/jbc.M308140200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14672948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14672948"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Yohei Oishi, Toshiya Arakawa, Akihiko Tanimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-005-0068-y"}], "href": "https://doi.org/10.1007/s00418-005-0068-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195891"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Marisol Ibarra-Ramírez, José de Jesús Lugo-Trampe, Luis Daniel Campos-Acevedo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene Copy Number Quantification of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SHOX"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VAMP7"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "SRY"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " for the Detection of Sex Chromosome Aneuploidies in Neonates."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2019.0226"}], "href": "https://doi.org/10.1089/gtmb.2019.0226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32423256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32423256"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Shadai Chávez-López, José de Jesús Lugo-Trampe, Marisol Ibarra-Ramírez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A case series of infants with increased VAMP7 gene dosage at birth and virilization defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Urol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jpurol.2019.11.001"}], "href": "https://doi.org/10.1016/j.jpurol.2019.11.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32622737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32622737"}]}]}]}
|
| Synonyms | TIVAMP, VAMP-7, SYBL1, TI-VAMP |
| Proteins | VAMP7_HUMAN |
| NCBI Gene ID | 6845 |
| API | |
| Download Associations | |
| Predicted Functions |
![]() |
| Co-expressed Genes |
![]() |
| Expression in Tissues and Cell Lines |
![]() |
VAMP7 has 5,782 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 107 datasets.
Click the + buttons to view associations for VAMP7 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by VAMP7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of VAMP7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of VAMP7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VAMP7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VAMP7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of VAMP7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with VAMP7 protein from the CCLE Cell Line Proteomics dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VAMP7 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of VAMP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of VAMP7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing VAMP7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VAMP7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing VAMP7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing VAMP7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing VAMP7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing VAMP7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with VAMP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with VAMP7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| CORUM Protein Complexes | protein complexs containing VAMP7 protein from the CORUM Protein Complexes dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of VAMP7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with VAMP7 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of VAMP7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by VAMP7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with VAMP7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with VAMP7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with VAMP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with VAMP7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing VAMP7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with VAMP7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with VAMP7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of VAMP7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with VAMP7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing VAMP7 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of VAMP7 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving VAMP7 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving VAMP7 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving VAMP7 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing VAMP7 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing VAMP7 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing VAMP7 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by VAMP7 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of VAMP7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of VAMP7 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for VAMP7 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of VAMP7 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of VAMP7 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of VAMP7 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of VAMP7 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| HPO Gene-Disease Associations | phenotypes associated with VAMP7 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for VAMP7 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with VAMP7 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for VAMP7 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of VAMP7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of VAMP7 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways | pathways involving VAMP7 protein from the KEGG Pathways dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of VAMP7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of VAMP7 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with VAMP7 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of VAMP7 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of VAMP7 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VAMP7 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing VAMP7 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain VAMP7 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by VAMP7 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting VAMP7 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of VAMP7 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by VAMP7 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for VAMP7 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of VAMP7 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for VAMP7 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VAMP7 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving VAMP7 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving VAMP7 protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with VAMP7 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate VAMP7 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
| Reactome Pathways 2014 | pathways involving VAMP7 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving VAMP7 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of VAMP7 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of VAMP7 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of VAMP7 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VAMP7 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VAMP7 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of VAMP7 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of VAMP7 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with VAMP7 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with VAMP7 gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of VAMP7 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of VAMP7 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of VAMP7 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of VAMP7 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of VAMP7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of VAMP7 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of VAMP7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of VAMP7 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with VAMP7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with VAMP7 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving VAMP7 protein from the Wikipathways Pathways 2014 dataset. | |