{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVAMP8 is a key vesicle‐associated membrane protein that functions as a v‐SNARE, orchestrating membrane fusion processes that are critical for autophagy. It facilitates the fusion of autophagosomes with lysosomes during both canonical and selective forms of autophagy, ensuring efficient degradation of intracellular cargo such as invading pathogens and aggregated proteins. Its activity is tightly regulated by multiple mechanisms including phosphorylation—for instance, mTORC1‐mediated phosphorylation of VAMP8 modulates SNARE complex assembly—and by regulators that control its endolysosomal trafficking. Together, these studies indicate that disruption of VAMP8 function may stall autophagosome maturation, leading to pathological accumulation of undegraded material and impacting antiviral as well as antimicrobial autophagy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its autophagic role, VAMP8 is pivotal in the regulated secretion pathways of diverse cell types. In platelets, for example, VAMP8 participates in dense granule exocytosis to support hemostasis; in mast cells, it collaborates with other SNAREs to mediate rapid degranulation essential for inflammatory responses. Moreover, VAMP8 has been implicated in the exocytotic traffic of cytotoxic T lymphocytes—where recycling endosomes fuse at the immune synapse—and is vital for secretory processes in airway and endothelial cells, such as mucin and von Willebrand factor release. These studies underscore its indispensable role in secretory granule exocytosis and precise membrane trafficking."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in autophagy and secretion, alterations in VAMP8 expression and genetic variation have been linked to a variety of pathophysiological and oncogenic processes. Overexpression of VAMP8 has been reported in malignant glioma and colorectal cancer, where it appears to promote tumor progression, chemoresistance, and metastatic suppression via interactions with other proteins that govern exocytosis and signaling pathways. Moreover, VAMP8 is implicated in antiviral responses—for instance, by regulating interferon signaling and enabling the fusion events necessary for viral entry—as well as in genetic predispositions to cardiovascular, pulmonary, and ocular conditions. Collectively, these findings highlight VAMP8 as not only a central mediator of vesicle fusion events but also a potential biomarker and molecular target in diverse disease states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nobumichi Furuta, Naonobu Fujita, Takeshi Noda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-08-0693"}], "href": "https://doi.org/10.1091/mbc.e09-08-0693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20089838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20089838"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Steve Jean, Sarah Cox, Sonya Nassari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embr.201439464"}], "href": "https://doi.org/10.15252/embr.201439464"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25648148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25648148"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yong Lin, Chunchen Wu, Xueyu Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Synaptosomal-associated protein 29 is required for the autophagic degradation of hepatitis B virus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.201801995RR"}], "href": "https://doi.org/10.1096/fj.201801995RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30742775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30742775"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ying Li, Xiaofang Cheng, Miao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome-lysosome fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2006997117"}], "href": "https://doi.org/10.1073/pnas.2006997117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32817423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32817423"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Luther J Davis, Nicholas A Bright, James R Edgar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.255463"}], "href": "https://doi.org/10.1242/jcs.255463"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34042162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34042162"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qixin Chen, Mingang Hao, Lei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prefused lysosomes cluster on autophagosomes regulated by VAMP8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04243-0"}], "href": "https://doi.org/10.1038/s41419-021-04243-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34645799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34645799"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yanhong Xing, Xiangqing Wei, Meng-Meng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Stimulating TRPM7 suppresses cancer cell proliferation and metastasis by inhibiting autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2021.10.043"}], "href": "https://doi.org/10.1016/j.canlet.2021.10.043"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34752845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34752845"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Hong Huang, Qinqin Ouyang, Min Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mTOR-mediated phosphorylation of VAMP8 and SCFD1 regulates autophagosome maturation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26824-5"}], "href": "https://doi.org/10.1038/s41467-021-26824-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34785650"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34785650"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yukiya Ohnishi, Daisuke Tsuji, Kohji Itoh "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative Stress Impairs Autophagy via Inhibition of Lysosomal Transport of VAMP8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Pharm Bull (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1248/bpb.b22-00131"}], "href": "https://doi.org/10.1248/bpb.b22-00131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36328496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36328496"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "János Polgár, Sul-Hee Chung, Guy L Reed "}, {"type": "b", "children": [{"type": "t", "text": "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v100.3.1081"}], "href": "https://doi.org/10.1182/blood.v100.3.1081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12130530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12130530"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yohei Oishi, Toshiya Arakawa, Akihiko Tanimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of VAMP-2, VAMP-7, and VAMP-8 in constitutive exocytosis from HSY cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Histochem Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00418-005-0068-y"}], "href": "https://doi.org/10.1007/s00418-005-0068-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16195891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16195891"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Leif E Sander, Simon P C Frank, Seza Bolat, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200737634"}], "href": "https://doi.org/10.1002/eji.200737634"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18253931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18253931"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Frédéric Bilan, Magali Nacfer, Fleur Fresquet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2008.04.012"}], "href": "https://doi.org/10.1016/j.yexcr.2008.04.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18570918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18570918"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Miki Okayama, Toshiya Arakawa, Akihiko Tanimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of VAMP8/endobrevin in constitutive exocytotic pathway in HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Struct Funct (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1247/csf.09013"}], "href": "https://doi.org/10.1247/csf.09013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19738360"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19738360"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lisa C Jones, Lama Moussa, M Leslie Fulcher, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/jphysiol.2011.222091"}], "href": "https://doi.org/10.1113/jphysiol.2011.222091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22144578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22144578"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Misty R Marshall, Varsha Pattu, Mahantappa Halimani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201411093"}], "href": "https://doi.org/10.1083/jcb.201411093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26124288"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26124288"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Ellie Karampini, Maaike Schillemans, Menno Hofman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2018.207787"}], "href": "https://doi.org/10.3324/haematol.2018.207787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30630984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30630984"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Joep F F Brinkman, Cecile P E Ottenheim, Leo A M S de Jong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP5 and VAMP8 are most likely not involved in primary open-angle glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16110299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16110299"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "May M Luke, Wolfgang Lalouschek, Charles M Rowland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cerebrovasc Dis (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000236914"}], "href": "https://doi.org/10.1159/000236914"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19752551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19752551"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Cheng-cheng Duan, Li-xin Xu, Qian Chen "}, {"type": "b", "children": [{"type": "t", "text": "[Association of the polymorphism of synaptobrevins/vesicle-associated membrane proteins 8 gene with coronary heart disease in Chinese Han population]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2010.0.020"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2010.0.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20533276"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20533276"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sara Dolatshahi Pirooz, Shanshan He, Tian Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1320629111"}], "href": "https://doi.org/10.1073/pnas.1320629111"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24550300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24550300"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuanyuan Chen, Delong Meng, Huibo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/nou219"}], "href": "https://doi.org/10.1093/neuonc/nou219"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25209430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25209430"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Ping Zhou, Shuo Zhang, Hongyan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "No association of VAMP8 gene polymorphisms with glioma in a Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2015)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26191281"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26191281"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yu-Shiuan Wang, Hong-Tai Tzeng, Chung-Han Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2018.08.023"}], "href": "https://doi.org/10.1016/j.canlet.2018.08.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30165196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30165196"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Shitong Cheng, Chao Sun, Wenting Lao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VAMP8"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " rs1010 Polymorphism with Host Susceptibility to Pulmonary Tuberculosis in a Chinese Han Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2018.0265"}], "href": "https://doi.org/10.1089/gtmb.2018.0265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30945947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30945947"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Sarah van Tol, Colm Atkins, Preeti Bharaj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01454-19"}], "href": "https://doi.org/10.1128/JVI.01454-19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31694946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31694946"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Nevena Kotarac, Zorana Dobrijevic, Suzana Matijasevic, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of KLK3, VAMP8 and MDM4 Genetic Variants within microRNA Binding Sites with Prostate Cancer: Evidence from Serbian Population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Oncol Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12253-020-00839-7"}], "href": "https://doi.org/10.1007/s12253-020-00839-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32556890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32556890"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Fenglei Jian, Shen Wang, Rui Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome-lysosome fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41422-023-00916-x"}], "href": "https://doi.org/10.1038/s41422-023-00916-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38182888"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38182888"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yi Xu, Tianyao Yang, Qiu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bioenerg Biomembr (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10863-024-10019-w"}], "href": "https://doi.org/10.1007/s10863-024-10019-w"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38720136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38720136"}]}]}]}