VANGL1 Gene

Name	VANGL planar cell polarity protein 1
Description	This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVANGL1 is an evolutionarily conserved, four‐transmembrane protein that plays a central role in the non‐canonical Wnt/planar cell polarity (PCP) pathway, critically regulating embryonic morphogenesis. Mutations in VANGL1—including missense variants that disrupt its interaction with key partners such as Dishevelled—have been associated with neural tube defects (NTDs) by impairing convergent extension movements in animal models and human patients. Studies have identified pathogenic VANGL1 variants in familial and sporadic cases of NTDs, with evidence from zebrafish and mouse models demonstrating that these mutations lead to mislocalization, reduced stability, and loss‐of-function. Genetic association studies in diverse populations and investigations into myelomeningocele and vertebral malformations further support a prominent role for VANGL1 in proper neural tube closure and tissue development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond developmental processes, VANGL1 has emerged as an important factor in tumor biology. Elevated levels of VANGL1 transcripts and its incorporation into cell polarity complexes have been correlated with poorer clinical outcomes in cancers such as breast and hepatocellular carcinoma. In addition, circular RNA isoforms derived from the VANGL1 gene (circ‑VANGL1) function as microRNA sponges that de‐repress oncogenic targets, thereby promoting cell migration, invasion, and epithelial-to-mesenchymal transition in bladder cancer, lung adenocarcinoma following irradiation, and melanoma. These studies underscore that VANGL1 and its circRNA derivatives can drive diverse aspects of cancer progression by modulating both cell polarity and survival signaling pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementary functional and structural studies have provided further insights into VANGL1’s biology. Molecular cloning and membrane topology analyses have defined VANGL1 as harboring four transmembrane domains with a predominantly intracellular C-terminus essential for its protein–protein interactions. In intestinal epithelial cells, VANGL1 phosphorylation in response to trefoil factor stimulation is linked to modulation of cell migration and wound healing. Moreover, emerging evidence indicates that circular RNA variants of VANGL1 may serve as prognostic biomarkers in bone-related disorders such as osteoporosis, while intronic deletions in VANGL1 have been implicated in predisposing the kidney to immune complex deposition and injury."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zoha Kibar, Elena Torban, Jonathan R McDearmid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in VANGL1 associated with neural-tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "N Engl J Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1056/NEJMoa060651"}], "href": "https://doi.org/10.1056/NEJMoa060651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17409324"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17409324"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zoha Kibar, Ciprian M Bosoi, Megan Kooistra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in VANGL1 in neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21026"}], "href": "https://doi.org/10.1002/humu.21026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19319979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19319979"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Annie Reynolds, Jonathan R McDearmid, Stephanie Lachance, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mod.2009.12.002"}], "href": "https://doi.org/10.1016/j.mod.2009.12.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20043994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20043994"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alexandra Iliescu, Michel Gravel, Cynthia Horth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of membrane targeting of Vangl proteins causes neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi101286d"}], "href": "https://doi.org/10.1021/bi101286d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21142127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21142127"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chunquan Cai, Ouyan Shi, Baiqi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between VANGL1 gene polymorphisms and neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropediatrics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1055/s-0033-1364103"}], "href": "https://doi.org/10.1055/s-0033-1364103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24407469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24407469"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "E Merello, S Mascelli, A Raso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the mutational spectrum associated to neural tube defects: literature revision and description of novel VANGL1 mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.23305"}], "href": "https://doi.org/10.1002/bdra.23305"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25208524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25208524"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tian Tian, Yunping Lei, Yongyan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-020-02172-0"}], "href": "https://doi.org/10.1007/s00439-020-02172-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32356230"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32356230"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Urooj Fatima, Shabnam Khan, Syeda Urooj Riaz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myelomeningocele among Pakistani population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pak Med Assoc (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.47391/JPMA.04-611"}], "href": "https://doi.org/10.47391/JPMA.04-611"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35713047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35713047"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Xin Feng, Yongyu Ye, Jianan Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2011.528"}], "href": "https://doi.org/10.1038/onc.2011.528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22179838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22179838"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gokhan Ozan Cetin, Asli Toylu, Nese Atabey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of VANGL1 inhibits cellular invasion rather than cell motility in hepatocellular carcinoma cells without stimulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Test Mol Biomarkers (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/gtmb.2015.0014"}], "href": "https://doi.org/10.1089/gtmb.2015.0014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25874746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25874746"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Zhihua Zeng, Wanming Zhou, Lingxing Duan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.27162"}], "href": "https://doi.org/10.1002/jcp.27162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30146736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30146736"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Dengke Yang, Haining Qian, Zhen Fang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing circular RNA VANGL1 inhibits progression of bladder cancer by regulating miR-1184/IGFBP2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2650"}], "href": "https://doi.org/10.1002/cam4.2650"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31758655"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31758655"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chun-Cheng Hao, Cui-Yang Xu, Xin-Yu Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of VANGL1 by IGF2BPs and miR-29b-3p attenuates the detrimental effect of irradiation on lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Clin Cancer Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13046-020-01772-y"}], "href": "https://doi.org/10.1186/s13046-020-01772-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33228740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33228740"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hongfeng Zhou, Jin Wu, Shaolong Leng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of circular RNA VANGL1 inhibits TGF-β-induced epithelial-mesenchymal transition in melanoma cells by sponging miR-150-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16887"}], "href": "https://doi.org/10.1111/jcmm.16887"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34750955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34750955"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Masaru Katoh "}, {"type": "b", "children": [{"type": "t", "text": "Molecular cloning and characterization of Strabismus 2 (STB2)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2002)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11956595"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11956595"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jiri Kalabis, Ian Rosenberg, Daniel K Podolsky "}, {"type": "b", "children": [{"type": "t", "text": "Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512905200"}], "href": "https://doi.org/10.1074/jbc.M512905200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16410243"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16410243"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Alexandra Iliescu, Philippe Gros "}, {"type": "b", "children": [{"type": "t", "text": "The intracellular carboxyl terminal domain of Vangl proteins contains plasma membrane targeting signals."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Protein Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pro.2432"}], "href": "https://doi.org/10.1002/pro.2432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24452931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24452931"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "L Yang, Z Zeng, N Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circ-VANGL1 promotes the progression of osteoporosis by absorbing miRNA-217 to regulate RUNX2 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_201902_16981"}], "href": "https://doi.org/10.26355/eurrev_201902_16981"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30779060"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30779060"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Simon H Jiang, Sevcan Mercan, Ilenia Papa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deletions in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VANGL1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " are a risk factor for antibody-mediated kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.xcrm.2021.100475"}], "href": "https://doi.org/10.1016/j.xcrm.2021.100475"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35028616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35028616"}]}]}]}
Synonyms	STB2, KITENIN, STBM2
Proteins	VANG1_HUMAN
NCBI Gene ID	81839
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VANGL1 has 7,158 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for VANGL1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VANGL1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by VANGL1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VANGL1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VANGL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VANGL1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VANGL1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VANGL1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VANGL1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of VANGL1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VANGL1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VANGL1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VANGL1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VANGL1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VANGL1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VANGL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VANGL1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with VANGL1 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with VANGL1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of VANGL1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing VANGL1 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VANGL1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VANGL1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing VANGL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing VANGL1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VANGL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VANGL1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VANGL1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VANGL1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with VANGL1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with VANGL1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VANGL1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VANGL1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VANGL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VANGL1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VANGL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VANGL1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VANGL1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VANGL1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.