VANGL2 Gene

Name	VANGL planar cell polarity protein 2
Description	The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVANGL2 is a core component of the planar cell polarity pathway whose activity is essential for proper embryonic development. It regulates the spatial organization and coordinated polarity of diverse tissues, mediating critical processes such as lung branching morphogenesis, neural tube closure, and cardiac as well as kidney formation. Disruption of VANGL2 function due to mutations or altered expression impairs epithelial integrity and morphogenetic movements, leading to congenital malformations including neural tube defects, Tetralogy of Fallot, heterotaxy, congenital scoliosis, and anomalies of the kidney and urinary tract."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the cellular level, VANGL2 function is tightly regulated by mechanisms controlling its intracellular trafficking and integration into the plasma membrane. Studies have demonstrated that specific sorting signals within its cytosolic domains and interactions with regulatory proteins such as Arfrp1, the clathrin adaptor complex AP‐1, and integrin complexes ensure its proper localization in polarized cells. In addition, VANGL2 modulates the formation of specialized filamentous structures known as cytonemes, which facilitate the paracrine distribution of Wnt ligands, thus fine‐tuning non‐canonical as well as canonical Wnt signaling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond development, aberrant VANGL2 expression and function contribute to pathological conditions including cancer and inflammatory disorders. In several tumor types such as basal breast cancer, colorectal cancer, and rhabdomyosarcoma, VANGL2 is implicated in tumor proliferation, invasion, and maintenance of tumor propagating cells through its interactions with proteins like p62/SQSTM1 and downstream effectors including RHOA and JNK. In addition, VANGL2 acts as a negative regulator of inflammatory signaling by promoting the degradation of NF‐κB component p65 via selective autophagy, thereby modulating the cellular response during sepsis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "E Erdal, C Erdal, G Bulut, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation analysis of the Vangl2 coding region revealed no common cause for Tetralogy of Fallot."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/147323000703500614"}], "href": "https://doi.org/10.1177/147323000703500614"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18034999"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18034999"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Laura L Yates, Carsten Schnatwinkel, Jennifer N Murdoch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddq104"}], "href": "https://doi.org/10.1093/hmg/ddq104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20223754"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20223754"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Z Kibar, S Salem, C M Bosoi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Contribution of VANGL2 mutations to isolated neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1399-0004.2010.01515.x"}], "href": "https://doi.org/10.1111/j.1399-0004.2010.01515.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20738329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20738329"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alexandra Iliescu, Michel Gravel, Cynthia Horth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of membrane targeting of Vangl proteins causes neural tube defects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi101286d"}], "href": "https://doi.org/10.1021/bi101286d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21142127"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21142127"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexandra Iliescu, Michel Gravel, Cynthia Horth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Independent mutations at Arg181 and Arg274 of Vangl proteins that are associated with neural tube defects in humans decrease protein stability and impair membrane targeting."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi500400g"}], "href": "https://doi.org/10.1021/bi500400g"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25068569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25068569"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuan Yuan, Yan Gao, Huijun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoter methylation and expression of the VANGL2 gene in the myocardium of pediatric patients with tetralogy of fallot."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Birth Defects Res A Clin Mol Teratol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/bdra.23291"}], "href": "https://doi.org/10.1002/bdra.23291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25200836"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25200836"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Eugenia Papakrivopoulou, Elisavet Vasilopoulou, Maja T Lindenmeyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vangl2, a planar cell polarity molecule, is implicated in irreversible and reversible kidney glomerular injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.5158"}], "href": "https://doi.org/10.1002/path.5158"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30125361"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30125361"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xin Feng, Yongyu Ye, Jianan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Core planar cell polarity genes "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VANGL1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "VANGL2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in predisposition to congenital vertebral malformations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2310283121"}], "href": "https://doi.org/10.1073/pnas.2310283121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38669183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38669183"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Nikola Pavlović, Nela Kelam, Anita Racetin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression Profiles of ITGA8 and VANGL2 Are Altered in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Molecules (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/molecules29143294"}], "href": "https://doi.org/10.3390/molecules29143294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39064873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39064873"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jiansen Lu, Jiahuan Zhang, Huaji Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.87935"}], "href": "https://doi.org/10.7554/eLife.87935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39269442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39269442"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yusong Guo, Giulia Zanetti, Randy Schekman "}, {"type": "b", "children": [{"type": "t", "text": "A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.00160"}], "href": "https://doi.org/10.7554/eLife.00160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23326640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23326640"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Markéta Kaucká, Julian Petersen, Pavlína Janovská, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Commun Signal (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12964-014-0079-1"}], "href": "https://doi.org/10.1186/s12964-014-0079-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25627785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25627785"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Tammy N Jessen, Jason R Jessen "}, {"type": "b", "children": [{"type": "t", "text": "VANGL2 interacts with integrin αv to regulate matrix metalloproteinase activity and cell adhesion to the extracellular matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2017.10.026"}], "href": "https://doi.org/10.1016/j.yexcr.2017.10.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29097183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29097183"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Tammy N Jessen, Jason R Jessen "}, {"type": "b", "children": [{"type": "t", "text": "VANGL2 protein stability is regulated by integrin αv and the extracellular matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2018.11.017"}], "href": "https://doi.org/10.1016/j.yexcr.2018.11.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30472097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30472097"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lucy Brunt, Gediminas Greicius, Sally Rogers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-22393-9"}], "href": "https://doi.org/10.1038/s41467-021-22393-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33824332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33824332"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "V Ashley Cantrell, Jason R Jessen "}, {"type": "b", "children": [{"type": "t", "text": "The planar cell polarity protein Van Gogh-Like 2 regulates tumor cell migration and matrix metalloproteinase-dependent invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2009.05.041"}], "href": "https://doi.org/10.1016/j.canlet.2009.05.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19577357"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19577357"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Tania M Puvirajesinghe, François Bertucci, Ashish Jain, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Planar cell polarity gene expression correlates with tumor cell viability and prognostic outcome in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-016-2293-2"}], "href": "https://doi.org/10.1186/s12885-016-2293-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27036398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27036398"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Madeline N Hayes, Karin McCarthy, Alexander Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2018.02.002"}], "href": "https://doi.org/10.1016/j.stem.2018.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29499154"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29499154"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Christopher J Derrick, Emmanuelle Szenker-Ravi, Adrian Santos-Ledo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddad171"}], "href": "https://doi.org/10.1093/hmg/ddad171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37815931"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37815931"}]}]}]}
Synonyms	STB1, STBM1, LTAP, STBM
Proteins	VANG2_HUMAN
NCBI Gene ID	57216
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VANGL2 has 6,027 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for VANGL2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VANGL2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VANGL2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VANGL2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VANGL2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VANGL2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VANGL2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VANGL2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VANGL2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VANGL2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VANGL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VANGL2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with VANGL2 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with VANGL2 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VANGL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VANGL2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VANGL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VANGL2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing VANGL2 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VANGL2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VANGL2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VANGL2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VANGL2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VANGL2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VANGL2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VANGL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VANGL2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VANGL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VANGL2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VANGL2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VANGL2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VANGL2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VANGL2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with VANGL2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with VANGL2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with VANGL2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing VANGL2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of VANGL2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of VANGL2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of VANGL2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.