| HGNC Family | Variable charge X/Y family (VCX, VCY) |
| Name | variable charge, X-linked 3B |
| Description | This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22, and the Y-linked members are two identical copies of the gene within a palindromic region on chromosome Yq11. The family members share a high degree of sequence identity, with the exception that a 30-nt unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This family member, as represented by the reference genome allele, contains 14 copies of the 30-nt repeat unit. VCX/Y genes encode small and highly charged proteins containing putative bipartite nuclear localization signals. Although the exact function of this family member has yet to be determined, a role in mRNA stability regulation can be inferred from the ability of the highly similar family member, VCX-A, to inhibit mRNA decapping. A possible role in the regulation of ribosome assembly during spermatogenesis has also been suggested. [provided by RefSeq, Aug 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMTMR14 is a phosphoinositide phosphatase that plays a central role in controlling intracellular calcium homeostasis, which is critical for proper muscle function. In skeletal muscles, MTMR14 dephosphorylates specific phosphatidylinositol phosphates to regulate Ca2+ release from intracellular stores, ensuring efficient excitation–contraction–relaxation cycles. Deficiency of MTMR14 leads to spontaneous Ca2+ leakage, reduced contractile force, and fatigue, while in aging muscles its downregulation is associated with phenotypes resembling sarcopenia. In addition, MTMR14 expression in the testes is essential for maintaining Ca2+ balance, as its deletion is linked to impaired sperm parameters, reduced muscle force in the vas deferens, and consequent fertility deficits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in calcium regulation, MTMR14 is a key modulator of autophagy and cell proliferation in various tissues. In mouse embryonic fibroblasts, loss of MTMR14 enhances cellular proliferation and autophagy, which is accompanied by alterations in cell cycle regulators. In the nervous system and liver, MTMR14 exerts protective effects against ischemia–reperfusion injury by interacting with signaling molecules such as PTEN and AKT, thereby restraining excessive autophagic activity and cell death. Similarly, in cardiac tissue, increased MTMR14 expression counteracts pressure overload-induced hypertrophy through modulation of the Akt pathway."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "7"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nMTMR14 also impacts vascular and metabolic homeostasis as well as cognitive function. Its deficiency exacerbates high‐fat diet–induced metabolic abnormalities by promoting lipid accumulation, inflammation, and disrupting PI3K/Akt and ERK signaling pathways. In the vasculature, MTMR14 prevents neointima formation by inhibiting polo-like kinase 1 (PLK1) and downstream MEK/ERK/AKT signaling, thereby curbing vascular smooth muscle cell proliferation following injury. Conversely, abnormal upregulation of MTMR14 in the brain has been linked to impaired autophagosome–lysosome fusion, reduced synaptic protein expression, and subsequent cognitive deficits."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jinhua Shen, Wen-Mei Yu, Marco Brotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1884"}], "href": "https://doi.org/10.1038/ncb1884"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19465920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19465920"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sandra Romero-Suarez, Jinhua Shen, Leticia Brotto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Muscle-specific inositide phosphatase (MIP/MTMR14) is reduced with age and its loss accelerates skeletal muscle aging process by altering calcium homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.100190"}], "href": "https://doi.org/10.18632/aging.100190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20817957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20817957"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nana Wen, Meng-Fei Yu, Jing Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of MTMR14 impairs male fertility in Mus musculus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0206224"}], "href": "https://doi.org/10.1371/journal.pone.0206224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30412589"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30412589"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jing Liu, Yin Lv, Qing-hua Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deficiency of MTMR14 promotes autophagy and proliferation of mouse embryonic fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-014-2015-5"}], "href": "https://doi.org/10.1007/s11010-014-2015-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24623267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24623267"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shufang Li, Meng Zhang, Bei Zhang "}, {"type": "b", "children": [{"type": "t", "text": "MTMR14 protects against hepatic ischemia-reperfusion injury through interacting with AKT signaling in vivo and in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2020.110455"}], "href": "https://doi.org/10.1016/j.biopha.2020.110455"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32768948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32768948"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jie-Lei Zhang, Dian-Hong Zhang, Ya-Peng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myotubularin-related protein 14 suppresses cardiac hypertrophy by inhibiting Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-020-2330-6"}], "href": "https://doi.org/10.1038/s41419-020-2330-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32080168"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32080168"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Qichen Pan, Yuan Liu, Gang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MTMR14 protects against cerebral stroke through suppressing PTEN-regulated autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.06.096"}], "href": "https://doi.org/10.1016/j.bbrc.2020.06.096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32819563"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32819563"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lv Yin, Peng Yong-Bo, Yu Meng-Fei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice lacking myotubularin-related protein 14 show accelerated high-fat diet-induced lipid accumulation and inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol Biochem (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13105-016-0520-6"}], "href": "https://doi.org/10.1007/s13105-016-0520-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27807764"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27807764"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ling-Yao Kong, Cui Liang, Peng-Cheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myotubularin-Related Protein14 Prevents Neointima Formation and Vascular Smooth Muscle Cell Proliferation by Inhibiting Polo-Like Kinase1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Heart Assoc (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/JAHA.122.026174"}], "href": "https://doi.org/10.1161/JAHA.122.026174"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36314496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36314496"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qiong Feng, Xiao Li, Ruijuan Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MTMR14 induced learning and memory impairments in 2-month-old C57 mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosci Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neulet.2024.137700"}], "href": "https://doi.org/10.1016/j.neulet.2024.137700"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38401642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38401642"}]}]}]}
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| Synonyms | VCXC, VCX-C |
| Proteins | VCX3B_HUMAN |
| NCBI Gene ID | 425054 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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VCX3B has 1,938 functional associations with biological entities spanning 7 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 47 datasets.
Click the + buttons to view associations for VCX3B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VCX3B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of VCX3B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with VCX3B gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of VCX3B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of VCX3B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing VCX3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing VCX3B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with VCX3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with VCX3B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of VCX3B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with VCX3B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with VCX3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with VCX3B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with VCX3B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VCX3B gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VCX3B gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of VCX3B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with VCX3B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing VCX3B from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VCX3B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving VCX3B gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving VCX3B gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing VCX3B protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing VCX3B protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing VCX3B protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of VCX3B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of VCX3B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VCX3B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with VCX3B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of VCX3B gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of VCX3B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of VCX3B gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of VCX3B protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for VCX3B protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of VCX3B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of VCX3B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of VCX3B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain VCX3B protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VCX3B gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of VCX3B gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of VCX3B gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of VCX3B gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of VCX3B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of VCX3B gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of VCX3B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with VCX3B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with VCX3B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
