VDAC3 Gene

HGNC Family	Ion channels
Name	voltage-dependent anion channel 3
Description	This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVDAC3 is a member of the voltage‐dependent anion channel family that, while sharing the conserved pore‐forming structure of its paralogs, displays unique functional properties in mitochondrial metabolism. Functional studies in heterologous systems have revealed that VDAC3 supports mitochondrial respiration less efficiently than VDAC1 and exhibits distinctive electrophysiological behavior—often appearing “weak” under basal conditions, yet capable of forming stable, highly conductive channels under specific modulating conditions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n \nIn addition, VDAC3 displays a high sensitivity to the redox environment. Its activity is modulated by the formation and reduction of intramolecular disulfide bonds—mechanisms elucidated through electrophysiological studies and molecular dynamics simulations—which ultimately impact its channel gating and conductance. Detailed analyses have shown that specific oxidative post‐translational modifications, including over‐oxidation of cysteine residues and deamidation events, finely tune VDAC3’s pore properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "8"}]}, {"type": "t", "text": "\n \nVDAC3 also engages in critical protein–protein interactions that shape cellular fate. In cancer models, for instance, VDAC3 binds with high affinity to antiapoptotic proteins such as Mcl-1, thereby influencing Ca²⁺ uptake and reactive oxygen species generation—a process that promotes cell migration and may contribute to tumor progression. Moreover, VDAC3 is targeted by the ferroptotic activator erastin, which induces its ubiquitination and degradation, highlighting its role as a modulator of regulated cell death in cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n \nBeyond its mitochondrial functions, VDAC3 performs extra‐mitochondrial roles. It localizes to centrosomes—specifically associating with the mother centriole—where it facilitates the recruitment of the Mps1 kinase to modulate proper centriole assembly and ciliary disassembly. This spatial distribution underscores a potential regulatory role in cell cycle progression and ciliogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n \nIn the realm of reproductive biology, VDAC3 emerges as a significant factor in sperm function. It has been identified as an abundant component of the sperm outer dense fibers and is a prominent target for S-nitrosylation in human spermatozoa, suggesting that redox modifications may regulate its activity in the context of fertilization. Furthermore, genetic variants in VDAC3 have been associated with alterations in sperm concentration, implying its involvement in spermatogenesis and sperm quality."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "16"}]}, {"type": "t", "text": "\n \nFinally, the emerging clinical relevance of VDAC3 is underscored by its dysregulation in diverse disease contexts. In septic cardiomyopathy, for example, gene coexpression analyses have identified VDAC3 as a hub gene potentially serving as a diagnostic biomarker, while its aberrant post‐translational modification profile has been implicated in neurodegenerative disorders such as amyotrophic lateral sclerosis. These findings broaden the scope of VDAC3’s functional impact from mitochondrial bioenergetics to the regulation of complex pathological processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vito De Pinto, Francesca Guarino, Andrea Guarnera, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of human VDAC isoforms: a peculiar function for VDAC3?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2010.01.031"}], "href": "https://doi.org/10.1016/j.bbabio.2010.01.031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20138821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20138821"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Vanessa Checchetto, Simona Reina, Andrea Magrì, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000363047"}], "href": "https://doi.org/10.1159/000363047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25171321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25171321"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "María Queralt-Martín, Lucie Bergdoll, Oscar Teijido, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gen Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1085/jgp.201912501"}], "href": "https://doi.org/10.1085/jgp.201912501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31935282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31935282"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Masateru Okazaki, Katsue Kurabayashi, Miwako Asanuma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VDAC3 gating is activated by suppression of disulfide-bond formation between the N-terminal region and the bottom of the pore."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2015.09.017"}], "href": "https://doi.org/10.1016/j.bbamem.2015.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26407725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26407725"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Carlo Guardiani, Loredana Leggio, Mariano Andrea Scorciapino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A computational study of ion current modulation in hVDAC3 induced by disulfide bonds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2016.01.013"}], "href": "https://doi.org/10.1016/j.bbamem.2016.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26806159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26806159"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Vito De Pinto, Simona Reina, Ankit Gupta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of cysteines in mammalian VDAC isoforms' function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbabio.2016.02.020"}], "href": "https://doi.org/10.1016/j.bbabio.2016.02.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26947058"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26947058"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Maria G G Pittalà, Rosaria Saletti, Simona Reina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21041468"}], "href": "https://doi.org/10.3390/ijms21041468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32098132"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32098132"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Maria Gaetana Giovanna Pittalà, Simona Reina, Stefano Conti Nibali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific Post-Translational Modifications of VDAC3 in ALS-SOD1 Model Cells Identified by High-Resolution Mass Spectrometry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms232415853"}], "href": "https://doi.org/10.3390/ijms232415853"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36555496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36555496"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "H Huang, K Shah, N A Bradbury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.419"}], "href": "https://doi.org/10.1038/cddis.2014.419"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25341036"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25341036"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yongfei Yang, Meiying Luo, Kexin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nedd4 ubiquitylates VDAC2/3 to suppress erastin-induced ferroptosis in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-020-14324-x"}], "href": "https://doi.org/10.1038/s41467-020-14324-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31974380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31974380"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Paweł Jóźwiak, Piotr Ciesielski, Ewa Forma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of voltage-dependent anion channels in endometrial cancer and its potential prognostic significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1010428320951057"}], "href": "https://doi.org/10.1177/1010428320951057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32829673"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32829673"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shubhra Majumder, Mark Slabodnick, Amanda Pike, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.21927"}], "href": "https://doi.org/10.4161/cc.21927"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22935710"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22935710"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Shubhra Majumder, Harold A Fisk "}, {"type": "b", "children": [{"type": "t", "text": "VDAC3 and Mps1 negatively regulate ciliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.23824"}], "href": "https://doi.org/10.4161/cc.23824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23388454"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23388454"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Klaus-Dieter Hinsch, Vito De Pinto, Viviana A Aires, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Voltage-dependent anion-selective channels VDAC2 and VDAC3 are abundant proteins in bovine outer dense fibers, a cytoskeletal component of the sperm flagellum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M313433200"}], "href": "https://doi.org/10.1074/jbc.M313433200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14739283"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14739283"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Linda Lefièvre, Yongjian Chen, Sarah J Conner, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.16891"}], "href": "https://doi.org/10.18632/oncotarget.16891"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28431403"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28431403"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kai Kang, Jingtian Li, Ruidong Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potentially Critical Roles of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "NDUFB5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TIMMDC1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "and VDAC3"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in the Progression of Septic Cardiomyopathy Through Integrated Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2019.4859"}], "href": "https://doi.org/10.1089/dna.2019.4859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31794266"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31794266"}]}]}]}
Synonyms	VDAC-3, HD-VDAC3
Proteins	VDAC3_HUMAN
NCBI Gene ID	7419
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VDAC3 has 7,082 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for VDAC3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VDAC3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VDAC3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VDAC3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VDAC3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VDAC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VDAC3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VDAC3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VDAC3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VDAC3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VDAC3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VDAC3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VDAC3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VDAC3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VDAC3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VDAC3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VDAC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VDAC3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VDAC3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VDAC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VDAC3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing VDAC3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing VDAC3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VDAC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VDAC3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VDAC3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VDAC3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VDAC3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VDAC3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VDAC3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VDAC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VDAC3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VDAC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VDAC3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for VDAC3 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VDAC3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VDAC3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VDAC3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VDAC3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with VDAC3 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of VDAC3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with VDAC3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.