VIPR2 Gene

HGNC Family	G protein-coupled receptors
Name	vasoactive intestinal peptide receptor 2
Description	This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. [provided by RefSeq, Aug 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVIPR2—the gene encoding the VPAC2 receptor for vasoactive intestinal peptide (VIP)—plays a pivotal role in the regulation of circadian rhythms and mood. In the suprachiasmatic nucleus (SCN), VPAC2 is expressed in distinct neuronal subpopulations where it contributes to autoregulation and intercellular coupling essential for maintaining circadian rhythmicity. Moreover, polymorphisms in VIPR2 have been linked to mood disorders, suggesting that genetic variation affecting VIP signalling may underlie differential susceptibility to major depression and bipolar disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn the immune system, VIPR2 influences T‐cell properties and inflammatory responses. Alternative splicing events generating deletion variants of VPAC2 in lymphocytes have been shown to diminish VIP-elicited signalling, thereby modulating T helper cell polarization. Furthermore, selective activation of VPAC2 has been reported to confer resistance to HIV-1 infection—by impairing the integration step of the viral life cycle—and to normalize immune responses in autoimmune contexts such as early arthritis. These observations underscore the importance of precise VPAC2 expression and functionality in balancing immune activation and inhibition."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nGenetic studies have also implicated VIPR2 in ocular and neuropsychiatric conditions. In high myopia, several single nucleotide polymorphisms and haplotypes within VIPR2 are significantly associated with altered axial length, suggesting that impaired VIP signalling may contribute to myopic development. In parallel, copy number variations and rare duplications of VIPR2 have been associated with increased risk for schizophrenia and opioid addiction, pointing to the broader neurodevelopmental and synaptic roles of VIPR2 in brain function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in circadian regulation and immune modulation, VIPR2 is emerging as a significant factor in oncogenesis and receptor pharmacology. In uterine leiomyosarcoma, frequent genetic alterations of VIPR2 correlate with poorer patient survival, while in human breast cancer cells, the VPAC2 receptor exhibits extranuclear localization and relatively lower expression compared with VPAC1. Additionally, advances in receptor pharmacology—exemplified by the efficient production of a recombinant VPAC2-selective agonist and the discovery of structurally important disulfide bond formation—provide new insights into receptor function and signal transduction that may facilitate the development of targeted therapies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Imre Kalló, Theodosis Kalamatianos, Nzinga Wiltshire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Neurosci (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.0953-816X.2004.03335.x"}], "href": "https://doi.org/10.1111/j.0953-816X.2004.03335.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15090046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15090046"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Virginia Soria, Erika Martínez-Amorós, Geòrgia Escaramís, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychopharmacology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/npp.2009.230"}], "href": "https://doi.org/10.1038/npp.2009.230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20072116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20072116"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Carola Grinninger, Wengang Wang, Kaveh Bastani Oskoui, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C400332200"}], "href": "https://doi.org/10.1074/jbc.C400332200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15302876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15302876"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Allison L Miller, Deepti Verma, Carola Grinninger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann N Y Acad Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1196/annals.1317.055"}], "href": "https://doi.org/10.1196/annals.1317.055"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16888203"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16888203"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Wei Sun, Jian Hong, Ying C Q Zang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Altered expression of vasoactive intestinal peptide receptors in T lymphocytes and aberrant Th1 immunity in multiple sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/intimm/dxl103"}], "href": "https://doi.org/10.1093/intimm/dxl103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17077178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17077178"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Payman Baradar Bokaei, Xue-Zhong Ma, Darinka Sakac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIV-1 integration is inhibited by stimulation of the VPAC2 neuroendocrine receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Virology (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.virol.2006.12.012"}], "href": "https://doi.org/10.1016/j.virol.2006.12.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17257640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17257640"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Jianmin Yuan, Chunhui Jin, Weiwei Sha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A competitive PCR assay confirms the association of a copy number variation in the VIPR2 gene with schizophrenia in Han Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Schizophr Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.schres.2014.04.004"}], "href": "https://doi.org/10.1016/j.schres.2014.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24794882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24794882"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "R Villanueva-Romero, I Gutiérrez-Cañas, M Carrión, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Th lymphocytes alters pattern expression and cellular location of VIP receptors in healthy donors and early arthritis patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43717-2"}], "href": "https://doi.org/10.1038/s41598-019-43717-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31089161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31089161"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Vanessa Nieratschker, Andreas Meyer-Lindenberg, Stephanie H Witt "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide investigation of rare structural variants identifies VIPR2 as a new candidate gene for schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Expert Rev Neurother (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1586/ern.11.84"}], "href": "https://doi.org/10.1586/ern.11.84"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21721910"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21721910"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Wai Chi Yiu, Maurice K H Yap, Wai Yan Fung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic susceptibility to refractive error: association of vasoactive intestinal peptide receptor 2 (VIPR2) with high myopia in Chinese."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0061805"}], "href": "https://doi.org/10.1371/journal.pone.0061805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23637909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23637909"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Orna Levran, Matthew Randesi, John Rotrosen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0224399"}], "href": "https://doi.org/10.1371/journal.pone.0224399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31689297"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31689297"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Kim Hung Leung, Shumeng Luo, Regina Kwarteng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The myopia susceptibility locus vasoactive intestinal peptide receptor 2 (VIPR2) contains variants with opposite effects."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-54619-8"}], "href": "https://doi.org/10.1038/s41598-019-54619-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796800"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kai Xiong Cheong, Rita Yu Yin Yong, Mellisa Mei Hui Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of VIPR2 and ZMAT4 with high myopia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ophthalmic Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13816810.2020.1737951"}], "href": "https://doi.org/10.1080/13816810.2020.1737951"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32166996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32166996"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ana Valdehita, Ana M Bajo, Ana B Fernández-Martínez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear localization of vasoactive intestinal peptide (VIP) receptors in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2010.07.024"}], "href": "https://doi.org/10.1016/j.peptides.2010.07.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20691743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20691743"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tine Cuppens, Matthieu Moisse, Jeroen Depreeuw, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31129"}], "href": "https://doi.org/10.1002/ijc.31129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29063609"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29063609"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Rong-jie Yu, Qiu-ling Xie, Yun Dai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intein-mediated rapid purification and characterization of a novel recombinant agonist for VPAC2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Peptides (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.peptides.2005.11.026"}], "href": "https://doi.org/10.1016/j.peptides.2005.11.026"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16500728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16500728"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Kotaro Sakamoto, Satoshi Asano, Yukio Ago, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "25"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-Cys"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "192"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": ") formation of functional significance for VIPR2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.10.071"}], "href": "https://doi.org/10.1016/j.bbrc.2022.10.071"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36332470"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36332470"}]}]}]}
Synonyms	PACAP-R-3, PACAP-R3, DUP7Q36.3, VIP-R-2, VPCAP2R, VPAC2, VPAC2R, C16DUPQ36.3
Proteins	VIPR2_HUMAN
NCBI Gene ID	7434
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VIPR2 has 5,053 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for VIPR2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VIPR2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VIPR2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VIPR2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VIPR2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VIPR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VIPR2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VIPR2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VIPR2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VIPR2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VIPR2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VIPR2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VIPR2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VIPR2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VIPR2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VIPR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VIPR2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing VIPR2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VIPR2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VIPR2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VIPR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VIPR2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VIPR2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VIPR2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VIPR2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VIPR2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with VIPR2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VIPR2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VIPR2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VIPR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VIPR2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VIPR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VIPR2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VIPR2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VIPR2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VIPR2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VIPR2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with VIPR2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with VIPR2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of VIPR2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with VIPR2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing VIPR2 from the GeneSigDB Published Gene Signatures dataset.