VPS13A Gene

Name	vacuolar protein sorting 13 homolog A (S. cerevisiae)
Description	The protein encoded by this gene may control steps in the cycling of proteins through the trans-Golgi network to endosomes, lysosomes and the plasma membrane. Mutations in this gene cause the autosomal recessive disorder, chorea-acanthocytosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVPS13A (chorein) functions as a lipid transfer protein that forms a long, tubular conduit capable of solubilizing and transporting glycerolipids between membranes. Its N‐terminal region is tubular and hydrophobic, enabling efficient lipid exchange at interorganelle contact sites such as those between the endoplasmic reticulum (ER) and mitochondria, late endosomes/lysosomes, and lipid droplets. Moreover, VPS13A is recruited to these contact sites by binding ER‐resident proteins (for example via a FFAT domain interaction with VAP‐A) and other adaptor proteins, thereby directly contributing to the maintenance of membrane lipid homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in lipid transport, VPS13A participates in the regulation of autophagy and endolysosomal trafficking. Studies in model organisms and cultured cells show that reduced VPS13A function leads to decreased autophagic flux, reduced autophagosome formation, and general impairments in endocytic dynamics. Moreover, distinct phosphoinositide‐binding domains, such as the APT1 domain sensitive to calcium and magnesium, modulate VPS13A activity, influencing both vesicle trafficking and its proper subcellular localization."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nVPS13A also has pivotal roles in cytoskeletal regulation and cell survival. It interacts with key actin‐associated proteins such as β‐adducin and β‐actin to help orchestrate actin polymerization and maintain cortical cytoskeletal architecture. In several cell types—including erythrocytes and platelets—chorein deficiency leads to actin depolymerization as well as pronounced changes in pro‐survival signaling cascades (for instance, a reduction in PI3K‐p85 phosphorylation and consequent effects on Rac1 and PAK1 activity), thereby promoting apoptotic pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurthermore, VPS13A interacts with key integral membrane proteins involved in lipid scrambling, such as XK, thereby linking bulk lipid transport to the re‐equilibration of lipids across the plasma membrane. This partnership not only modulates membrane lipid asymmetry—a process vital to signal transduction and membrane repair—but also influences local lipid composition at sites of organelle contacts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence further implicates VPS13A in the regulation of metabolic processes. Its interaction with proteins such as TBC1D1 suggests a role in modulating GLUT4 trafficking and insulin‐responsive glucose uptake, linking defects in VPS13A function to insulin resistance and potentially other metabolic dysfunctions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFinally, mutations that truncate or alter the C‐terminal domains (including the pleckstrin homology region) of VPS13A disturb its proper localization and protein–protein interactions, underpinning the pathogenesis of chorea‐acanthocytosis. These mutations disrupt VPS13A’s ability to form proper membrane contact sites and engage its binding partners, thereby contributing to the neurodegenerative and cellular phenotypes observed in patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nikit Kumar, Marianna Leonzino, William Hancock-Cerutti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201807019"}], "href": "https://doi.org/10.1083/jcb.201807019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30093493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30093493"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wondwossen M Yeshaw, Marianne van der Zwaag, Francesco Pinto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human VPS13A is associated with multiple organelles and influences mitochondrial morphology and lipid droplet motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.43561"}], "href": "https://doi.org/10.7554/eLife.43561"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30741634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30741634"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sandra Muñoz-Braceras, Alba R Tornero-Écija, Olivier Vincent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Model Mech (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dmm.036681"}], "href": "https://doi.org/10.1242/dmm.036681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30709847"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30709847"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jae-Sook Park, Aaron M Neiman "}, {"type": "b", "children": [{"type": "t", "text": "XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E19-08-0439-T"}], "href": "https://doi.org/10.1091/mbc.E19-08-0439-T"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32845802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32845802"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jyoti Adlakha, Zhouping Hong, PeiQi Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural and biochemical insights into lipid transport by VPS13 proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202202030"}], "href": "https://doi.org/10.1083/jcb.202202030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35357422"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35357422"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sandra Muñoz-Braceras, Rosa Calvo, Ricardo Escalante "}, {"type": "b", "children": [{"type": "t", "text": "TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2015.1034413"}], "href": "https://doi.org/10.1080/15548627.2015.1034413"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25996471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25996471"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Damian Kolakowski, Joanna Kaminska, Teresa Zoladek "}, {"type": "b", "children": [{"type": "t", "text": "The binding of the APT1 domains to phosphoinositides is regulated by metal ions in vitro."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Biomembr (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamem.2020.183349"}], "href": "https://doi.org/10.1016/j.bbamem.2020.183349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32407779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32407779"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Weronika Rzepnikowska, Krzysztof Flis, Joanna Kaminska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx054"}], "href": "https://doi.org/10.1093/hmg/ddx054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28334785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28334785"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hannes Glaß, Patrick Neumann, Arun Pal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21051797"}], "href": "https://doi.org/10.3390/ijms21051797"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32151030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32151030"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michael Föller, Andreas Hermann, Shuchen Gu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chorein-sensitive polymerization of cortical actin and suicidal cell death in chorea-acanthocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.11-198317"}], "href": "https://doi.org/10.1096/fj.11-198317"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22227296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22227296"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Eva-Maria Schmidt, Evi Schmid, Patrick Münzer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chorein sensitivity of cytoskeletal organization and degranulation of platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.13-229286"}], "href": "https://doi.org/10.1096/fj.13-229286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23568775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23568775"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Nari Shiokawa, Masayuki Nakamura, Mieko Sameshima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chorein, the protein responsible for chorea-acanthocytosis, interacts with β-adducin and β-actin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2013.10.011"}], "href": "https://doi.org/10.1016/j.bbrc.2013.10.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24129186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24129186"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sabina Honisch, Shuchen Gu, Jennifer Müller Vom Hagen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chorein Sensitive Arrangement of Cytoskeletal Architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000430363"}], "href": "https://doi.org/10.1159/000430363"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26316086"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26316086"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jae-Sook Park, Yiying Hu, Nancy M Hollingsworth, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between VPS13A and the XK scramblase is important for VPS13A function in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.260227"}], "href": "https://doi.org/10.1242/jcs.260227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35950506"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35950506"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Andrés Guillén-Samander, Yumei Wu, S Sebastian Pineda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A partnership between the lipid scramblase XK and the lipid transfer protein VPS13A at the plasma membrane."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2205425119"}], "href": "https://doi.org/10.1073/pnas.2205425119"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35994651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35994651"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Sharon C Hook, Alexandra Chadt, Kate J Heesom, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-020-74661-1"}], "href": "https://doi.org/10.1038/s41598-020-74661-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33087848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33087848"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Alba Tornero-Écija, Antonia Zapata-Del-Baño, Laura Antón-Esteban, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202201852"}], "href": "https://doi.org/10.26508/lsa.202201852"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36977596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36977596"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ricky M Ditzel, Ruth H Walker, Melissa J Nirenberg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Autopsy Series of Seven Cases of VPS13A Disease (Chorea-Acanthocytosis)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mov Disord (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mds.29589"}], "href": "https://doi.org/10.1002/mds.29589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37670483"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37670483"}]}]}]}
Synonyms	CHAC, CHOREIN
Proteins	VP13A_HUMAN
NCBI Gene ID	23230
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VPS13A has 7,151 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 124 datasets.

Click the + buttons to view associations for VPS13A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VPS13A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS13A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS13A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VPS13A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VPS13A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VPS13A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS13A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VPS13A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VPS13A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VPS13A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of VPS13A gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VPS13A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VPS13A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VPS13A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VPS13A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VPS13A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VPS13A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VPS13A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with VPS13A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with VPS13A gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VPS13A gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VPS13A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VPS13A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing VPS13A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing VPS13A protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VPS13A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VPS13A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VPS13A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VPS13A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VPS13A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VPS13A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with VPS13A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of VPS13A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VPS13A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving VPS13A gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving VPS13A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with VPS13A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VPS13A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VPS13A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VPS13A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VPS13A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.