VPS33B Gene

Name	vacuolar protein sorting 33 homolog B (yeast)
Description	Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVPS33B is a key regulator of vesicle fusion and intracellular trafficking. As a homolog of yeast Vps33, this Sec1/Munc18 family protein governs the formation and assembly of SNARE complexes, thereby ensuring correct vesicle docking and fusion events in the endosomal–lysosomal system. Structural and biochemical investigations have revealed that VPS33B, in complex with VPS16B, adopts a distinct two‐lobed architecture that may facilitate bidirectional interactions with multiple SNARE bundles, enabling finely tuned membrane fusion events crucial for diverse cellular functions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMutations in VPS33B are causative for arthrogryposis–renal dysfunction–cholestasis (ARC) syndrome, a recessively inherited multisystem disorder. Deficient or aberrant VPS33B activity disrupts intracellular trafficking pathways and organelle biogenesis, notably impairing the formation and sorting of platelet α‐granule proteins and derailing multivesicular body maturation in megakaryocytes. Genetic analyses have identified a spectrum of VPS33B variants—including splice‐site, nonsense, and missense mutations—with some mutations correlating with milder phenotypes, thereby highlighting genotype–phenotype relationships in ARC syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn megakaryocytes and platelets, VPS33B is essential for α‐granule biogenesis. By partnering with VPS16B and localizing to recycling endosomes, VPS33B directs the trafficking of newly synthesized granule cargo, safeguarding these proteins from premature lysosomal degradation. Additional interactions with fusogenic proteins such as Syntaxin 12, as well as components of the COMMD3/CCC complex, further integrate VPS33B into a machinery that orchestrates vesicle docking, fusion, and regulated secretion necessary for normal platelet function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vesicle trafficking and granule formation, VPS33B functions as a tumor suppressor in several cancers. Reduced expression or inactivation of VPS33B disrupts epithelial polarity and affects key signaling cascades—such as the EGFR/PI3K/AKT and c-Myc/p53 pathways—often via interactions with the tumor suppressor NESG1. These perturbations contribute to enhanced proliferation, metastatic potential, and chemoresistance in malignancies including hepatocellular carcinoma, nasopharyngeal carcinoma, colorectal cancer, and ovarian cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nVPS33B further contributes to host–pathogen interactions and the modulation of receptor signaling. In Mycobacterium tuberculosis infections, for example, VPS33B serves as a substrate for the secreted bacterial phosphatase PtpA; its dephosphorylation is associated with impaired phagosome–lysosome fusion, thereby facilitating intracellular bacterial survival. In parallel, interactions between VPS33B and the adaptor protein SPE-39 modulate EGFR downregulation following EGF stimulation, underscoring a broader role for VPS33B in controlling receptor turnover and downstream signaling dynamics."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, specific VPS33B mutations can manifest in dermatologic phenotypes. For instance, certain missense variants disrupt VPS33B interactions with Rab proteins involved in the trafficking of the collagen-modifying enzyme LH3, leading to aberrant lamellar body secretion essential for epidermal barrier formation. These defects underlie the clinical presentation seen in keratoderma–ichthyosis–deafness syndrome, expanding the phenotypic spectrum associated with VPS33B dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Paul Gissen, Colin A Johnson, Neil V Morgan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng1325"}], "href": "https://doi.org/10.1038/ng1325"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15052268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15052268"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Paul Gissen, Colin A Johnson, Dean Gentle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi137"}], "href": "https://doi.org/10.1093/hmg/ddi137"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15790593"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15790593"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Richard J Y Liu, Yusef Al-Molieh, Shao Z Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Sec1-Munc18 protein VPS33B forms a uniquely bidirectional complex with VPS16B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2023.104718"}], "href": "https://doi.org/10.1016/j.jbc.2023.104718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37062417"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37062417"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bryan Lo, Ling Li, Paul Gissen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-04-1356"}], "href": "https://doi.org/10.1182/blood-2005-04-1356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16123220"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16123220"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Joo Young Jang, Kyung Mo Kim, Gu-Hwan Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Clinical characteristics and VPS33B mutations in patients with ARC syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Gastroenterol Nutr (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/mpg.0b013e31817fcb3f"}], "href": "https://doi.org/10.1097/mpg.0b013e31817fcb3f"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19274792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19274792"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Holly Smith, Romain Galmes, Ekaterina Gogolina, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22155"}], "href": "https://doi.org/10.1002/humu.22155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22753090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22753090"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li-Ting Li, Jing Zhao, Rui Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two novel VPS33B mutations in a patient with arthrogryposis, renal dysfunction and cholestasis syndrome in mainland China."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v20.i1.326"}], "href": "https://doi.org/10.3748/wjg.v20.i1.326"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24415890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24415890"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian-She Wang, Jing Zhao, Li-Ting Li "}, {"type": "b", "children": [{"type": "t", "text": "ARC syndrome with high GGT cholestasis caused by VPS33B mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.v20.i16.4830"}], "href": "https://doi.org/10.3748/wjg.v20.i16.4830"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24782640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24782640"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "S H Seo, S M Hwang, J M Ko, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel mutations in the VPS33B gene involved in arthrogryposis, renal dysfunction, and cholestasis syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12442"}], "href": "https://doi.org/10.1111/cge.12442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24917129"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24917129"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Danai Bem, Holly Smith, Blerida Banushi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS33B regulates protein sorting into and maturation of α-granule progenitor organelles in mouse megakaryocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2014-12-614677"}], "href": "https://doi.org/10.1182/blood-2014-12-614677"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25947942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25947942"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Denisa Urban, Ling Li, Hilary Christensen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-05-431205"}], "href": "https://doi.org/10.1182/blood-2012-05-431205"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23002115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23002115"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Andrea L Ambrosio, Santiago M Di Pietro "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of platelet α-granule biogenesis: study of cargo transport and the VPS33B-VPS16B complex in a model system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2018028969"}], "href": "https://doi.org/10.1182/bloodadvances.2018028969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31501156"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31501156"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Andrea L Ambrosio, Hallie P Febvre, Santiago M Di Pietro "}, {"type": "b", "children": [{"type": "t", "text": "Syntaxin 12 and COMMD3 are new factors that function with VPS33B in the biogenesis of platelet α-granules."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.2021012056"}], "href": "https://doi.org/10.1182/blood.2021012056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34905616"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34905616"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Conghui Wang, Yuqiang Cheng, Xiuping Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.30077"}], "href": "https://doi.org/10.1002/hep.30077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29729199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29729199"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Zixi Liang, Zhen Liu, Chao Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS33B interacts with NESG1 to modulate EGFR/PI3K/AKT/c-Myc/P53/miR-133a-3p signaling and induce 5-fluorouracil sensitivity in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1457-9"}], "href": "https://doi.org/10.1038/s41419-019-1457-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30944308"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30944308"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yiyu Chen, Zhen Liu, Huijun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.32429"}], "href": "https://doi.org/10.1002/ijc.32429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31125123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31125123"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Yingxia Ning, Zhaoyang Zeng, Yuao Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VPS33B interacts with NESG1 to suppress cell growth and cisplatin chemoresistance in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14864"}], "href": "https://doi.org/10.1111/cas.14864"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33788346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33788346"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Horacio Bach, Kadamba G Papavinasasundaram, Dennis Wong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mycobacterium tuberculosis virulence is mediated by PtpA dephosphorylation of human vacuolar protein sorting 33B."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Host Microbe (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.chom.2008.03.008"}], "href": "https://doi.org/10.1016/j.chom.2008.03.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18474358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18474358"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ayumi Ishii, Kanae Kamimori, Mineyoshi Hiyoshi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibitory effect of SPE-39 due to tyrosine phosphorylation and ubiquitination on the function of Vps33B in the EGF-stimulated cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.05.051"}], "href": "https://doi.org/10.1016/j.febslet.2012.05.051"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22677173"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22677173"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Robert Gruber, Clare Rogerson, Christian Windpassinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autosomal Recessive Keratoderma-Ichthyosis-Deafness (ARKID) Syndrome Is Caused by VPS33B Mutations Affecting Rab Protein Interaction and Collagen Modification."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jid.2016.12.010"}], "href": "https://doi.org/10.1016/j.jid.2016.12.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28017832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28017832"}]}]}]}
Proteins	VP33B_HUMAN
NCBI Gene ID	26276
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VPS33B has 6,677 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 110 datasets.

Click the + buttons to view associations for VPS33B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VPS33B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS33B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS33B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VPS33B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VPS33B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VPS33B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VPS33B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of VPS33B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VPS33B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VPS33B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VPS33B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VPS33B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VPS33B protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VPS33B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VPS33B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VPS33B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with VPS33B gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with VPS33B gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of VPS33B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VPS33B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VPS33B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with VPS33B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VPS33B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VPS33B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VPS33B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VPS33B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VPS33B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VPS33B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving VPS33B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VPS33B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with VPS33B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VPS33B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VPS33B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VPS33B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VPS33B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VPS33B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VPS33B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VPS33B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with VPS33B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with VPS33B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of VPS33B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.