| HGNC Family | Immunoglobulin superfamily domain containing |
| Name | V-set and immunoglobulin domain containing 4 |
| Description | This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVSIG4—also known as CRIg or Z39Ig—is a macrophage‐restricted receptor that exerts dual functions in innate immune defense. It binds complement fragments C3b and iC3b, thereby facilitating the rapid phagocytosis and clearance of opsonized pathogens. Structural studies have revealed that VSIG4 recognition of activated C3 fragments not only enables efficient uptake but can also trigger the formation of autophagosomes to eliminate intracellular microorganisms. In addition, VSIG4 is involved in modulating complement activation by inhibiting alternative pathway convertases, which further assists in maintaining immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in innate immunity, VSIG4 serves as a potent negative regulator of adaptive immune responses. In vitro and in vivo studies demonstrate that VSIG4 engagement suppresses T cell activation, proliferation, and cytokine production. This inhibitory costimulatory function helps to maintain T cell unresponsiveness under homeostatic conditions and contributes to the fine‐tuning of immune responses during chronic infections. Moreover, approaches such as the transfection of dendritic cells with VSIG4 have been shown to induce T cell suppression, highlighting its potential utility in immunotherapeutic applications."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of VSIG4 expression has been implicated in a broad spectrum of pathological conditions. In the context of pregnancy, upmodulation of VSIG4 transcription serves as a potential diagnostic marker for severe preeclampsia. Within tumor microenvironments, such as those observed in lung, ovarian, glioblastoma, and colorectal cancers, increased VSIG4 expression on tumor‐associated macrophages is associated with impaired T cell responses, promotion of epithelial–mesenchymal transition, enhanced stem cell–like properties, and chemoresistance. In parallel, aberrant VSIG4 signaling contributes to the pathology of metabolic and inflammatory diseases—including nonalcoholic fatty liver disease, alcohol‐related liver injury, rheumatoid arthritis, and inflammatory bowel disease—by dysregulating cytokine production and fibrotic responses. Emerging data also point to regulatory interactions with molecules such as PKCα, Rab18, and NF‑κB, as well as the therapeutic promise of VSIG4‐targeted fusion proteins designed to modulate complement-mediated injury in conditions like renal ischemia reperfusion. Collectively, these findings indicate that VSIG4 not only orchestrates pathogen clearance and limits excessive inflammation but also represents a promising target for immunomodulatory therapies across diverse disease states."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "23"}]}, {"type": "t", "text": "\n\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Karim Y Helmy, Kenneth J Katschke, Nick N Gorgani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2005.12.039"}], "href": "https://doi.org/10.1016/j.cell.2005.12.039"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16530040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16530040"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Min-Young Lee, Won-Jung Kim, Yoon-Joong Kang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Z39Ig is expressed on macrophages and may mediate inflammatory reactions in arthritis and atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0306160"}], "href": "https://doi.org/10.1189/jlb.0306160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16882875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16882875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Christian Wiesmann, Kenneth J Katschke, JianPing Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure of C3b in complex with CRIg gives insights into regulation of complement activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature05263"}], "href": "https://doi.org/10.1038/nature05263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17051150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17051150"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Masashi Tanaka, Taku Nagai, Makoto Usami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Innate Immun (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1753425911400641"}], "href": "https://doi.org/10.1177/1753425911400641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21768202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21768202"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kwang H Kim, Beom K Choi, Young H Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2016.1196314"}], "href": "https://doi.org/10.1080/15548627.2016.1196314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27440002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27440002"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nagaraja Nagre, Xiaofei Cong, César Terrazas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2017-0236OC"}], "href": "https://doi.org/10.1165/rcmb.2017-0236OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29268030"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29268030"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lorenz Vogt, Nicole Schmitz, Michael O Kurrer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VSIG4, a B7 family-related protein, is a negative regulator of T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI25673"}], "href": "https://doi.org/10.1172/JCI25673"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17016562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17016562"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Shuxiong Xu, Zhaolin Sun, Lian Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of T cells suppression by dendritic cells transfected with VSIG4 recombinant adenovirus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunol Lett (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.imlet.2009.11.003"}], "href": "https://doi.org/10.1016/j.imlet.2009.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19914289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19914289"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sheng Guo, Chengying Yang, Feng Mei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Down-regulation of Z39Ig on macrophages by IFN-gamma in patients with chronic HBV infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Immunol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.clim.2010.03.007"}], "href": "https://doi.org/10.1016/j.clim.2010.03.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20399148"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20399148"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Qian Qiao, Xiaoyan Teng, Na Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel CRIg-targeted complement inhibitor protects cells from complement damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.14-258046"}], "href": "https://doi.org/10.1096/fj.14-258046"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25114177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25114177"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Julien Textoris, Delphine Ivorra, Amira Ben Amara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evaluation of current and new biomarkers in severe preeclampsia: a microarray approach reveals the VSIG4 gene as a potential blood biomarker."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0082638"}], "href": "https://doi.org/10.1371/journal.pone.0082638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24349325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24349325"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yunmei Liao, Sheng Guo, Yongwen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VSIG4 expression on macrophages facilitates lung cancer development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2014.73"}], "href": "https://doi.org/10.1038/labinvest.2014.73"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24862966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24862966"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yuefang Ma, Kanchana Usuwanthim, Usma Munawara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase cα regulates the expression of complement receptor Ig in human monocyte-derived macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1303477"}], "href": "https://doi.org/10.4049/jimmunol.1303477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25687755"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25687755"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Xin-Hua Zhang, Yun Qian, Zheng Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Let-7g-5p inhibits epithelial-mesenchymal transition consistent with reduction of glioma stem cell phenotypes by targeting VSIG4 in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2016.5098"}], "href": "https://doi.org/10.3892/or.2016.5098"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27634309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27634309"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jung Mi Byun, Dae Hoon Jeong, In Hak Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Significance of VSIG4 Expression in Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gynecol Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/IGC.0000000000000979"}], "href": "https://doi.org/10.1097/IGC.0000000000000979"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28498255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28498255"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Seung-Mi Kim, Se Won Oh, Sang Hyun Park, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epstein-Barr virus-encoded latent membrane protein 1 induces epithelial to mesenchymal transition by inducing V-set Ig domain containing 4 (VSIG4) expression via NF-kB in renal tubular epithelial HK-2 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2017.08.116"}], "href": "https://doi.org/10.1016/j.bbrc.2017.08.116"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28859984"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28859984"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Chao Hu, Long Li, Peipei Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Complement Inhibitor CRIg/FH Ameliorates Renal Ischemia Reperfusion Injury via Activation of PI3K/AKT Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1800987"}], "href": "https://doi.org/10.4049/jimmunol.1800987"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30429287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30429287"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yang Li, Ji-Ping Sun, Jing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of Vsig4 attenuates macrophage-mediated hepatic inflammation and fibrosis in high fat diet (HFD)-induced mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.06.045"}], "href": "https://doi.org/10.1016/j.bbrc.2019.06.045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31266632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31266632"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Fabiana Antunes Andrade, Isabela Goeldner Eibofner, Cristhine Pieczarka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Immunogenet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/iji.12533"}], "href": "https://doi.org/10.1111/iji.12533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33645007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33645007"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Kai Yang, Zhi Wang "}, {"type": "b", "children": [{"type": "t", "text": "Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1919012"}], "href": "https://doi.org/10.1080/21655979.2021.1919012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33904378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33904378"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yi Duan, Huikuan Chu, Katharina Brandl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27385-3"}], "href": "https://doi.org/10.1038/s41467-021-27385-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34887405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34887405"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yuan Liao, Chaonan Deng, Xichuan Wang "}, {"type": "b", "children": [{"type": "t", "text": "VSIG4 ameliorates intestinal inflammation through inhibiting macrophages NLRP3 inflammasome and pyroptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2023.102285"}], "href": "https://doi.org/10.1016/j.tice.2023.102285"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38113649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38113649"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Yik Yan Chong, Sasinthiran Thiagarajan, Qiu Xuan Tan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The immunomodulatory role of paracrine signalling factor VSIG4 in peritoneal metastases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-64449-y"}], "href": "https://doi.org/10.1038/s41598-024-64449-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39080370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39080370"}]}]}]}
|
| Synonyms | CRIG, Z39IG |
| Proteins | VSIG4_HUMAN |
| NCBI Gene ID | 11326 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
VSIG4 has 4,700 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 99 datasets.
Click the + buttons to view associations for VSIG4 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of VSIG4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of VSIG4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of VSIG4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of VSIG4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VSIG4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of VSIG4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of VSIG4 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of VSIG4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of VSIG4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with VSIG4 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VSIG4 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of VSIG4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of VSIG4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing VSIG4 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VSIG4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing VSIG4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing VSIG4 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with VSIG4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with VSIG4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of VSIG4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with VSIG4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with VSIG4 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by VSIG4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with VSIG4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with VSIG4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with VSIG4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with VSIG4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VSIG4 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of VSIG4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of VSIG4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing VSIG4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of VSIG4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with VSIG4 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing VSIG4 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of VSIG4 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GlyGen Glycosylated Proteins | ligands (chemical) binding VSIG4 protein from the GlyGen Glycosylated Proteins dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving VSIG4 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving VSIG4 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving VSIG4 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing VSIG4 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by VSIG4 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by VSIG4 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of VSIG4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of VSIG4 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with VSIG4 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of VSIG4 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of VSIG4 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of VSIG4 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP ASCT+B Augmented with RNA-seq Coexpression | cell types associated with VSIG4 gene from the HuBMAP ASCT+B Augmented with RNA-seq Coexpression dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with VSIG4 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with VSIG4 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by VSIG4 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for VSIG4 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of VSIG4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of VSIG4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of VSIG4 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEGG Pathways 2026 | pathways involving VSIG4 protein from the KEGG Pathways 2026 dataset. | |
| Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate VSIG4 protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of VSIG4 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of VSIG4 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of VSIG4 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of VSIG4 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of VSIG4 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing VSIG4 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain VSIG4 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by VSIG4 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of VSIG4 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by VSIG4 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of VSIG4 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NURSA Protein Complexes | protein complexs containing VSIG4 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for VSIG4 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of VSIG4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of VSIG4 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving VSIG4 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving VSIG4 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at VSIG4 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of VSIG4 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of VSIG4 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of VSIG4 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of VSIG4 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of VSIG4 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of VSIG4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of VSIG4 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of VSIG4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of VSIG4 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with VSIG4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with VSIG4 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2024 | pathways involving VSIG4 protein from the WikiPathways Pathways 2024 dataset. | |
