VTI1A Gene

Name	vesicle transport through interaction with t-SNAREs 1A
Description	The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nVTI1A plays a multifaceted role in cancer biology. In colorectal cancer, genomic rearrangements can result in recurrent, oncogenic fusion genes between VTI1A and TCF7L2. The resulting VTI1A-TCF7L2 fusion protein, which notably lacks the β-catenin-binding domain normally present in TCF7L2, has been shown to be essential for anchorage-independent growth and appears to act as a dominant negative regulator of Wnt signaling. In addition, novel fusion variants and transcription-induced chimeras involving VTI1A have been reported in both tumor and normal tissues, implying that such rearrangements may contribute to oncogenesis in a context-dependent manner. Genome-wide association studies have further implicated common intronic variants within VTI1A in modulating susceptibility to multiple cancers, including colorectal cancer, glioma, and lung cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its involvement in oncogenic processes, VTI1A is a key component of intracellular vesicular trafficking. It localizes to intracellular vesicles and interacts with other SNARE proteins—such as VAMP7—to facilitate the proper transport of cargos including Kv4 channel complexes from the endoplasmic reticulum via specialized vesicular intermediates to the plasma membrane. Furthermore, VTI1A participates in the maintenance of Golgi apparatus architecture; its depletion, along with that of one of its SNARE partners, disrupts Golgi ribbon integrity by impairing retrograde trafficking from the early endosome to the trans-Golgi network."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Adam J Bass, Michael S Lawrence, Lear E Brace, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.936"}], "href": "https://doi.org/10.1038/ng.936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21892161"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21892161"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hansong Wang, Terrilea Burnett, Suminori Kono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms5613"}], "href": "https://doi.org/10.1038/ncomms5613"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25105248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25105248"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Torfinn Nome, Andreas M Hoff, Anne Cathrine Bakken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091264"}], "href": "https://doi.org/10.1371/journal.pone.0091264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24608966"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24608966"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Johanne Davidsen, Sylvester Larsen, Mehmet Coskun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0200215"}], "href": "https://doi.org/10.1371/journal.pone.0200215"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29975781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29975781"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ning Wang, Zhong Deng, Maode Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Additional evidence supports association of common genetic variants in VTI1A and ETFA with increased risk of glioma susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2017.02.013"}], "href": "https://doi.org/10.1016/j.jns.2017.02.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28320150"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28320150"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Wen-Mei Su, Zhi-Hong Chen, Xu-Chao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Markers (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5301/jbm.5000140"}], "href": "https://doi.org/10.5301/jbm.5000140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25744365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25744365"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sarah E Flowerdew, Robert D Burgoyne "}, {"type": "b", "children": [{"type": "t", "text": "A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20081736"}], "href": "https://doi.org/10.1042/BJ20081736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19138172"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19138172"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Akiko Shitara, Toru Shibui, Miki Okayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VAMP4 is required to maintain the ribbon structure of the Golgi apparatus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-013-1652-4"}], "href": "https://doi.org/10.1007/s11010-013-1652-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23677696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23677696"}]}]}]}
Synonyms	VTI1RP2, VTI1-RP2, MMDS3, MVTI1
Proteins	VTI1A_HUMAN
NCBI Gene ID	143187
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

VTI1A has 7,323 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 112 datasets.

Click the + buttons to view associations for VTI1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

VTI1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by VTI1A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VTI1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of VTI1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of VTI1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of VTI1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of VTI1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of VTI1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VTI1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of VTI1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of VTI1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of VTI1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with VTI1A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with VTI1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VTI1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of VTI1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of VTI1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing VTI1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing VTI1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with VTI1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing VTI1A protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of VTI1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with VTI1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with VTI1A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with VTI1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with VTI1A gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of VTI1A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by VTI1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with VTI1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with VTI1A gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with VTI1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with VTI1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with VTI1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at VTI1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of VTI1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of VTI1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing VTI1A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with VTI1A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with VTI1A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with VTI1A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing VTI1A from the GeneSigDB Published Gene Signatures dataset.