{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWASF1 (also known as WAVE1) is a central regulator of actin‐cytoskeletal dynamics that couples upstream Rho family GTPase signals to the activation of the Arp2/3 complex, thereby promoting branched actin nucleation. In multiple experimental systems, WASF1 has been shown to mediate the formation and spatial organization of lamellipodia, pseudopods, and filopodia that underlie diverse forms of cell migration. Its activity is modulated by complex formation with proteins such as PIR121, Nap1, HSPC300, profilin, Ena/VASP and others, and regulated by mechanisms including phosphorylation, dimerization, and targeted messenger RNA localization to dynamic membrane regions. These features collectively enable WASF1 to drive processes such as immune cell motility, dendritic spine morphogenesis, and membrane‐ruffling necessary for directional movement."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its fundamental role in organizing actin assembly, aberrant regulation of WASF1 has been implicated in multiple disease contexts. In several cancer types—including breast, ovarian and prostate—elevated or altered WASF1 expression contributes to enhanced cell migration, invasion, and chemoresistance, thereby correlating with adverse clinical outcomes. In hematological malignancies, particularly in leukemias, WASF1 modulation influences drug responsiveness and apoptotic thresholds. Moreover, dysregulation of WASF1 appears to interface with neurodegenerative processes as well as with the production and trafficking of amyloid precursor proteins, indicating its involvement in Alzheimer’s disease pathology. Collectively, these data underscore a role for WASF1 not only in normal cellular motility but also as a key factor in disease progression when its regulation is compromised."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its direct effects on actin polymerization and cell protrusion, WASF1 functions as an integrator of diverse signaling inputs and as part of larger regulatory complexes that influence cellular differentiation and tissue morphogenesis. For example, studies have revealed that WASF1 activity can be fine‑tuned by its interaction with regulatory proteins (including members of the Dock family), by inhibitory domains that affect filament elongation, and by localized mRNA translation at the cell periphery—all of which contribute to accurate spatial and temporal control of actin assembly. These multifunctional regulatory features play critical roles in processes as varied as osteoblast-mediated bone formation and neural connectivity, highlighting WASF1 as a pivotal node in the coordination of cytoskeletal dynamics with developmental and stress‑response pathways."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "32", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sharon Eden, Rajat Rohatgi, Alexandre V Podtelejnikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature00859"}], "href": "https://doi.org/10.1038/nature00859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12181570"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12181570"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Defne Yarar, Joseph A D'Alessio, Robert L Jeng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Motility determinants in WASP family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e02-05-0294"}], "href": "https://doi.org/10.1091/mbc.e02-05-0294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12429845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12429845"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ru Feng Wu, Ying Gu, You Cheng Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302251200"}], "href": "https://doi.org/10.1074/jbc.M302251200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12855698"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12855698"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Atsushi Oda, Hiroaki Miki, Ikuo Wada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE/Scars in platelets."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-04-1319"}], "href": "https://doi.org/10.1182/blood-2003-04-1319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15280206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15280206"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S L Blagg, R H Insall "}, {"type": "b", "children": [{"type": "t", "text": "Control of SCAR activity in Dictyostelium discoideum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Soc Trans (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BST0321113"}], "href": "https://doi.org/10.1042/BST0321113"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15506982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15506982"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "H Kashiwagi, M Shiraga, H Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Thromb Haemost (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1538-7836.2004.01082.x"}], "href": "https://doi.org/10.1111/j.1538-7836.2004.01082.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15670045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15670045"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Orion D Weiner, William A Marganski, Lani F Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An actin-based wave generator organizes cell motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0050221"}], "href": "https://doi.org/10.1371/journal.pbio.0050221"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17696648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17696648"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jee Young Sung, Olivia Engmann, Merilee A Teylan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE1 controls neuronal activity-induced mitochondrial distribution in dendritic spines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0712180105"}], "href": "https://doi.org/10.1073/pnas.0712180105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18287015"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18287015"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Petra Beli, Debora Mascheroni, Dalu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1745"}], "href": "https://doi.org/10.1038/ncb1745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18516090"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18516090"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shae B Padrick, Hui-Chun Cheng, Ayman M Ismail, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hierarchical regulation of WASP/WAVE proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.10.012"}], "href": "https://doi.org/10.1016/j.molcel.2008.10.012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18995840"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18995840"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kazuhiko Namekata, Chikako Harada, Choji Taya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0914514107"}], "href": "https://doi.org/10.1073/pnas.0914514107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20368433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20368433"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Vassilis Koronakis, Peter J Hume, Daniel Humphreys, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE regulatory complex activation by cooperating GTPases Arf and Rac1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1107666108"}], "href": "https://doi.org/10.1073/pnas.1107666108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21844371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21844371"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wah Ing Goh, Kim Buay Lim, Thankiah Sudhaharan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.305102"}], "href": "https://doi.org/10.1074/jbc.M111.305102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22179776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22179776"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Haoran Tang, Ang Li, Jing Bi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Biol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cub.2012.11.059"}], "href": "https://doi.org/10.1016/j.cub.2012.11.059"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23273897"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23273897"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Mark Willett, Michele Brocard, Hilary J Pollard, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mRNA encoding WAVE-Arp2/3-associated proteins is co-localized with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20121803"}], "href": "https://doi.org/10.1042/BJ20121803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23452202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23452202"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Svitlana Havrylenko, Philippe Noguera, Majdouline Abou-Ghali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE binds Ena/VASP for enhanced Arp2/3 complex-based actin assembly."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-07-1200"}], "href": "https://doi.org/10.1091/mbc.E14-07-1200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25355952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25355952"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Adam G Sowalsky, Rebecca Sager, Rachel J Schaefer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of Wave1 gene defines a subtype of lethal prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3564"}], "href": "https://doi.org/10.18632/oncotarget.3564"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25906751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25906751"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Lillian K Fritz-Laylin, Samuel J Lord, R Dyche Mullins "}, {"type": "b", "children": [{"type": "t", "text": "WASP and SCAR are evolutionarily conserved in actin-filled pseudopod-based motility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201701074"}], "href": "https://doi.org/10.1083/jcb.201701074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28473602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28473602"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yoko Ito, Keren J Carss, Sofia T Duarte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2018.06.001"}], "href": "https://doi.org/10.1016/j.ajhg.2018.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29961568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29961568"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Masayuki Ozawa, Sylvain Hiver, Takaki Yamamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202006196"}], "href": "https://doi.org/10.1083/jcb.202006196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32886101"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32886101"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Rui Kang, Li-zhi Cao, Yan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Role of WAVE1 in drug resistance of K562/A02 leukemia cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Xue Ye Xue Za Zhi (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17939402"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17939402"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Yu-Lei He, Li-Zhi Cao, Jing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of WAVE1 and p22phox in children with acute lymphocytic leukemia and the relationship of WAVE1 with oxidative stress]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhongguo Dang Dai Er Ke Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19222940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19222940"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Kazuyuki Takata, Yoshihisa Kitamura, Yukinori Nakata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Pathol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2353/ajpath.2009.080908"}], "href": "https://doi.org/10.2353/ajpath.2009.080908"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19497998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19497998"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yu-Lei He, Li-Zhi Cao, Ming-Hua Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Role of WAVE1 in K562 leukemia cells invasion and its mechanism]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Xue Ye Xue Za Zhi (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19731823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19731823"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "R Kang, D Tang, Y Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2009.224"}], "href": "https://doi.org/10.1038/leu.2009.224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19890377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19890377"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Ming-hua Yang, Ming-yi Zhao, Yu-lei He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Interaction of WAVE1 and genes involved in multiple drug resistance in children with acute myeloblastic leukemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Er Ke Za Zhi (2010)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20426950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20426950"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jing Zhang, Liangdan Tang, Liyuan Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High level of WAVE1 expression is associated with tumor aggressiveness and unfavorable prognosis of epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2012.06.008"}], "href": "https://doi.org/10.1016/j.ygyno.2012.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22721732"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22721732"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jing Zhang, Suiyang Zhou, Liangdan Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE1 gene silencing via RNA interference reduces ovarian cancer cell invasion, migration and proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gynecol Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ygyno.2013.05.005"}], "href": "https://doi.org/10.1016/j.ygyno.2013.05.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23680521"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23680521"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Valentina Marchesin, Guillaume Montagnac, Philippe Chavrier "}, {"type": "b", "children": [{"type": "t", "text": "ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0121747"}], "href": "https://doi.org/10.1371/journal.pone.0121747"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25799492"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25799492"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Zhaoxia Zhang, Benqing Wu, Wenwen Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3446"}], "href": "https://doi.org/10.3892/ijo.2016.3446"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27035872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27035872"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Jing Cheng, Yuan Song, Jing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA PVT1 promotes the malignant progression of acute myeloid leukaemia via sponging miR-29 family to increase WAVE1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pathol.2020.11.003"}], "href": "https://doi.org/10.1016/j.pathol.2020.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33558065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33558065"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Meredith O Sweeney, Agnieszka Collins, Shae B Padrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel role for WAVE1 in controlling actin network growth rate and architecture."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E14-10-1477"}], "href": "https://doi.org/10.1091/mbc.E14-10-1477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25473116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25473116"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Madison L Doolittle, Gina M Calabrese, Larry D Mesner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic analysis of osteoblast activity identifies Zbtb40 as a regulator of osteoblast activity and bone mass."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1008805"}], "href": "https://doi.org/10.1371/journal.pgen.1008805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32497039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32497039"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Qing Tang, Matthias Schaks, Neha Koundinya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E19-12-0705"}], "href": "https://doi.org/10.1091/mbc.E19-12-0705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32697617"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32697617"}]}]}]}