WDR36 Gene

HGNC Family	WD repeat domain containing (WDR)
Name	WD repeat domain 36
Description	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWDR36 has emerged as a gene of considerable interest in studies of primary open‐angle glaucoma (POAG) and its juvenile forms. A multitude of independent genetic investigations across diverse populations—including European, East Asian, Australian, and German cohorts—have identified rare non‐synonymous variants in WDR36 that may act as modifier factors in a complex, polygenic disease background."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": " Functional studies in yeast have further revealed that WDR36 is homologous to Utp21p—a component of the small subunit processome that is essential for the maturation of 18S rRNA and proper ribosome biogenesis. This conserved role in rRNA processing suggests that subtle defects in ribosome assembly may alter cellular homeostasis in retinal ganglion cells and contribute to glaucomatous neurodegeneration.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its involvement in ocular disorders, genome‐wide association studies have reported that WDR36 variants exhibit suggestive associations with immunological parameters. For example, sequence variants in WDR36 have been linked to differences in blood eosinophil counts and to atopic asthma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": ", although investigations in eosinophilic esophagitis have shown that its expression remains unaltered."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": " Similarly, analyses in nasal polyposis did not reveal functional consequences of WDR36 mutations"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": ", collectively indicating that its immunogenetic associations may be subtle and context‐dependent.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its established role in ribosome assembly, emerging biochemical evidence indicates that WDR36 functions as a scaffold protein involved in intracellular signal transduction. Studies have demonstrated that WDR36 directly interacts with the thromboxane A₂ receptor, Gαq, and phospholipase Cβ—thereby enhancing G-protein–coupled receptor signaling after receptor stimulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": " Such multifunctionality implies that WDR36 may influence cellular processes beyond protein synthesis, and that perturbations in its scaffolding role could further contribute to the complex pathogenesis observed in glaucoma.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sharareh Monemi, George Spaeth, Alexander DaSilva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddi068"}], "href": "https://doi.org/10.1093/hmg/ddi068"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15677485"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15677485"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chi Pui Pang, Bao Jian Fan, Oscar Canlas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide scan maps a novel juvenile-onset primary open angle glaucoma locus to chromosome 5q."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Vis (2006)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16518310"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16518310"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael A Hauser, R Rand Allingham, Kevin Linkroum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distribution of WDR36 DNA sequence variants in patients with primary open-angle glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.05-1476"}], "href": "https://doi.org/10.1167/iovs.05-1476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16723468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16723468"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alex W Hewitt, David P Dimasi, David A Mackey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Glaucoma Case-control Study of the WDR36 Gene D658G sequence variant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Ophthalmol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajo.2006.02.041"}], "href": "https://doi.org/10.1016/j.ajo.2006.02.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16876519"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16876519"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Patricia L Kramer, John R Samples, Sharareh Monemi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Association between primary open-angle glaucoma (POAG) and WDR36 sequence variance in Italian families affected by POAG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Ophthalmol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/bjo.2009.167494"}], "href": "https://doi.org/10.1136/bjo.2009.167494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20813748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20813748"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Cristina Blanco-Marchite, Francisco Sánchez-Sánchez, María-Pilar López-Garrido, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Common variants at 5q22 associate with pediatric eosinophilic esophagitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.547"}], "href": "https://doi.org/10.1038/ng.547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208534"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208534"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "I D Buysschaert, V Grulois, P Eloy, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic evidence for a role of IL33 in nasal polyposis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Allergy (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1398-9995.2009.02227.x"}], "href": "https://doi.org/10.1111/j.1398-9995.2009.02227.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19860791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19860791"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Andréane Cartier, Audrey Parent, Pascale Labrecque, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.085795"}], "href": "https://doi.org/10.1242/jcs.085795"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21940795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21940795"}]}]}]}
Synonyms	GLC1G, TA-WDRP, UTP21, TAWDRP
Proteins	WDR36_HUMAN
NCBI Gene ID	134430
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

WDR36 has 6,464 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 120 datasets.

Click the + buttons to view associations for WDR36 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

WDR36 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR36 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR36 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of WDR36 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of WDR36 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of WDR36 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WDR36 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of WDR36 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of WDR36 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of WDR36 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of WDR36 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with WDR36 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WDR36 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of WDR36 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of WDR36 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with WDR36 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with WDR36 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing WDR36 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing WDR36 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing WDR36 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing WDR36 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with WDR36 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with WDR36 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of WDR36 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with WDR36 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with WDR36 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with WDR36 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with WDR36 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving WDR36 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving WDR36 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with WDR36 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with WDR36 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with WDR36 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with WDR36 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with WDR36 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with WDR36 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at WDR36 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WDR36 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of WDR36 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing WDR36 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with WDR36 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.