{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the query requested a summary of the function of WDR97, the provided abstract (PMID:"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "does not include any details on WDR97. Instead, this abstract focuses on Integrator complex subunit 15 (INTS15), which is highly expressed in the eye and brain during embryogenesis. INTS15 functions as a stable component of the Integrator complex, where it facilitates the proper 3′ end processing of small nuclear RNAs. Disruption of INTS15—either through homozygous knockout leading to embryonic lethality in mice or through specific C-terminal mutations producing ocular malformations similar to the human condition—results in widespread splicing defects that negatively affect genes crucial for ocular and neural development.\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMoreover, studies using human iPS cell–derived neural progenitor cells highlighted that INTS15 is essential for axonal outgrowth in retinal ganglion cells, thereby establishing a direct link between a broadly acting transcriptional machinery component and a highly specific hereditary disease affecting the eye and brain. It is important to note that while INTS15 plays a critical role as delineated by this work, the abstract does not provide any information regarding the function of WDR97.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Noriyuki Azuma, Tadashi Yokoi, Taku Tanaka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Integrator complex subunit 15 controls mRNA splicing and is critical for eye development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddad034"}], "href": "https://doi.org/10.1093/hmg/ddad034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36851842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36851842"}]}]}]}