| HGNC Family | WAP four-disulfide core domain containing (WFDC) |
| Name | WAP four-disulfide core domain 13 |
| Description | This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough the provided abstracts were intended to help elucidate the function of WFDC13, none of them mention or address WFDC13. Instead, the studies uniformly focus on interleukin‐1 receptor–associated kinase 4 (IRAK4) as a pivotal mediator of innate immune signaling. These reports demonstrate that IRAK4 links Toll‐like receptor (TLR) and interleukin‑1 receptor (IL‑1R) engagement via the MyD88 adaptor to downstream signaling cascades—including NF‑κB and MAPK pathways—that ultimately trigger the production of proinflammatory cytokines essential for host defense against diverse microbial challenges."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSeveral studies further establish that the kinase activity of IRAK4 is indispensable for propagating both innate and adaptive immune responses. Genetic ablation or pharmacological inhibition of IRAK4 in various animal models results in markedly reduced cytokine production, impaired activation of downstream kinases (e.g., IRAK1, JNK, and p38), and mitigated inflammatory tissue damage in models of sepsis, atherosclerosis, autoimmune conditions, and bacterial infections. These data underscore its therapeutic relevance, as targeted inhibition of IRAK4 can attenuate excessive inflammatory responses while preserving essential host defenses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn contrast to the extensive and insightful information regarding IRAK4’s central role in immune signaling and inflammatory disease pathogenesis, none of the examined abstracts provide any data on WFDC13. As a result, while these studies present IRAK4 as an attractive target for modulating inflammatory responses, the function of WFDC13 in immune regulation remains unaddressed in this body of literature."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nobutaka Suzuki, Shinobu Suzuki, Gordon S Duncan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature736"}], "href": "https://doi.org/10.1038/nature736"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11923871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11923871"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kimberly Burns, Sophie Janssens, Brian Brissoni, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20021790"}], "href": "https://doi.org/10.1084/jem.20021790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12538665"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12538665"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Nobutaka Suzuki, Nien-Jung Chen, Douglas G Millar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.170.8.4031"}], "href": "https://doi.org/10.4049/jimmunol.170.8.4031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12682231"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12682231"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Elizabeth Lye, Christine Mirtsos, Nobutaka Suzuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402666200"}], "href": "https://doi.org/10.1074/jbc.M402666200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15292196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15292196"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Michael V Lasker, Mark M Gajjar, Satish K Nair "}, {"type": "b", "children": [{"type": "t", "text": "Cutting edge: molecular structure of the IL-1R-associated kinase-4 death domain and its implications for TLR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.175.7.4175"}], "href": "https://doi.org/10.4049/jimmunol.175.7.4175"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16177054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16177054"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nobutaka Suzuki, Shinobu Suzuki, Douglas G Millar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for the innate immune signaling molecule IRAK-4 in T cell activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1124256"}], "href": "https://doi.org/10.1126/science.1124256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16574867"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16574867"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Tae Whan Kim, Kirk Staschke, Katarzyna Bulek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20061825"}], "href": "https://doi.org/10.1084/jem.20061825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17470642"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17470642"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20061523"}], "href": "https://doi.org/10.1084/jem.20061523"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17485511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17485511"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Maria Loiarro, Federica Capolunghi, Nicola Fantò, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pivotal Advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.1206746"}], "href": "https://doi.org/10.1189/jlb.1206746"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17548806"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17548806"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Mark Rekhter, Kirk Staschke, Thomas Estridge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.12.186"}], "href": "https://doi.org/10.1016/j.bbrc.2007.12.186"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18190779"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18190779"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Elizabeth Lye, Salim Dhanji, Thomas Calzascia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200737429"}], "href": "https://doi.org/10.1002/eji.200737429"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18286567"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18286567"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Magdalena Koziczak-Holbro, Amanda Littlewood-Evans, Bernadette Pöllinger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.24552"}], "href": "https://doi.org/10.1002/art.24552"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19479877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19479877"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Kirk A Staschke, Sucai Dong, Joy Saha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.0802361"}], "href": "https://doi.org/10.4049/jimmunol.0802361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19542468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19542468"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Eugene Y Chiang, Xin Yu, Jane L Grogan "}, {"type": "b", "children": [{"type": "t", "text": "Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across human cell types."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1002821"}], "href": "https://doi.org/10.4049/jimmunol.1002821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21160042"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21160042"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Tae Whan Kim, Maria Febbraio, Peggy Robinet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1002242"}], "href": "https://doi.org/10.4049/jimmunol.1002242"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21278342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21278342"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Yanbao Xiong, Andrei E Medvedev "}, {"type": "b", "children": [{"type": "t", "text": "Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Leukoc Biol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1189/jlb.0611273"}], "href": "https://doi.org/10.1189/jlb.0611273"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21934070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21934070"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Horst von Bernuth, Capucine Picard, Anne Puel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Experimental and natural infections in MyD88- and IRAK-4-deficient mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.201242683"}], "href": "https://doi.org/10.1002/eji.201242683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23255009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23255009"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Md A Nahid, Bing Yao, Paul R Dominguez-Gutierrez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of TLR2-mediated tolerance and cross-tolerance through IRAK4 modulation by miR-132 and miR-212."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1103060"}], "href": "https://doi.org/10.4049/jimmunol.1103060"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23264652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23264652"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Yan Xu, Huiyi Jin, Xiaolu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-93 inhibits inflammatory cytokine production in LPS-stimulated murine macrophages by targeting IRAK4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2014.03.013"}], "href": "https://doi.org/10.1016/j.febslet.2014.03.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24642374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24642374"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xikun Zhou, Xuefeng Li, Yan Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms4619"}], "href": "https://doi.org/10.1038/ncomms4619"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24717937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24717937"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sambit K Nanda, Marta Lopez-Pelaez, J Simon C Arthur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1600788"}], "href": "https://doi.org/10.4049/jimmunol.1600788"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27807192"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27807192"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Sarah J Mancini, Anna D White, Silvia Bijland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2016.11.010"}], "href": "https://doi.org/10.1016/j.mce.2016.11.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27840174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27840174"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Irina A Leaf, Shunsaku Nakagawa, Bryce G Johnson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI87532"}], "href": "https://doi.org/10.1172/JCI87532"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27869651"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27869651"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Dominic De Nardo, Katherine R Balka, Yamel Cardona Gloria, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a dual role in myddosome formation and Toll-like receptor signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.003314"}], "href": "https://doi.org/10.1074/jbc.RA118.003314"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30076215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30076215"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Zhigao Wang, Long Jiang, Daquan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "USP13-mediated IRAK4 deubiquitination disrupts the pathological symptoms of lipopolysaccharides-induced sepsis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbes Infect (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.micinf.2021.104867"}], "href": "https://doi.org/10.1016/j.micinf.2021.104867"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34298177"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34298177"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Alexandre Picard, Xavier Berney, Judit Castillo-Armengol, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypothalamic Irak4 is a genetically controlled regulator of hypoglycemia-induced glucagon secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Metab (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molmet.2022.101479"}], "href": "https://doi.org/10.1016/j.molmet.2022.101479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35339728"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35339728"}]}]}]}
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| Synonyms | C20ORF138, DJ601O1.3, WAP13 |
| Proteins | WFD13_HUMAN |
| NCBI Gene ID | 164237 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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WFDC13 has 1,919 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 59 datasets.
Click the + buttons to view associations for WFDC13 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of WFDC13 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of WFDC13 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of WFDC13 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of WFDC13 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of WFDC13 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of WFDC13 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of WFDC13 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of WFDC13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of WFDC13 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of WFDC13 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing WFDC13 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with WFDC13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with WFDC13 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of WFDC13 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with WFDC13 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| dbGAP Gene-Trait Associations | traits associated with WFDC13 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by WFDC13 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with WFDC13 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at WFDC13 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of WFDC13 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of WFDC13 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GAD Gene-Disease Associations | diseases associated with WFDC13 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with WFDC13 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of WFDC13 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of WFDC13 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of WFDC13 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of WFDC13 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving WFDC13 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving WFDC13 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving WFDC13 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing WFDC13 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by WFDC13 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by WFDC13 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of WFDC13 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of WFDC13 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of WFDC13 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with WFDC13 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with WFDC13 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of WFDC13 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of WFDC13 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for WFDC13 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of WFDC13 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of WFDC13 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of WFDC13 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of WFDC13 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of WFDC13 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain WFDC13 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of WFDC13 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of WFDC13 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of WFDC13 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at WFDC13 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of WFDC13 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of WFDC13 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of WFDC13 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of WFDC13 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of WFDC13 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of WFDC13 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with WFDC13 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with WFDC13 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
