WNK2 Gene

Name	WNK lysine deficient protein kinase 2
Description	The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWNK2 is a serine/threonine kinase with diverse roles across multiple tissues. In the nervous system, WNK2 is preferentially expressed in neurons where it promotes chloride accumulation by stimulating the NKCC1 cotransporter while inhibiting KCC2 activity, thereby modulating cell volume and γ-aminobutyric acid (GABA)–ergic neurotransmission. In addition, studies in Drosophila and mammalian cell systems suggest that WNK kinases help maintain optimal levels of canonical Wnt/β-catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " \n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several cancers, WNK2 functions as a tumor suppressor that is frequently inactivated by genetic and epigenetic mechanisms. Epigenomic analyses in gliomas and other brain tumors have revealed that WNK2 is often silenced by promoter hypermethylation, deletion, and even point mutations, events that are associated with enhanced cell proliferation and invasion. In meningiomas, for instance, aberrant methylation of the WNK2 promoter correlates with decreased expression and may underlie dysregulated epidermal growth factor receptor signaling via diminished MEK1 inhibition. In pancreatic ductal adenocarcinoma, WNK2 downregulation is linked to activation of the ERK–MAPK pathway, while in colon cancer and MSI‐high tumors, frameshift mutations and reduced protein levels underscore its role as a cell growth suppressor."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMechanistically, WNK2 modulates intracellular signaling cascades that govern cell proliferation and migration. Depletion of WNK2 leads to decreased RhoA and enhanced Rac1 GTP-loading, resulting in activation of PAK1 and subsequent phosphorylation of MEK1, thereby increasing ERK1/2 activation. In gliomas, loss of WNK2 further correlates with increased JNK activity and upregulation of matrix metalloproteinase-2, promoting invasion. Moreover, oncogenic microRNAs (e.g., miR-370) and long non-coding RNAs (e.g., LINC00858) have been shown to negatively regulate WNK2 expression in breast, colon, and gastric cancers, thereby enhancing tumor cell proliferation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in modulating kinase signaling and tumor cell behavior, WNK2 has been implicated in the regulation of other cellular processes. In glioblastoma cells, WNK2 overexpression inhibits autophagic flux through a mechanism that appears to bypass the canonical mTOR pathway. In airway epithelial cells, particularly in cystic fibrosis models, inhibition or knockdown of WNK2 (alongside other WNK kinases) leads to reduced chloride secretion and increased bicarbonate secretion, ultimately alkalinizing the airway surface liquid and potentially improving host defenses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jesse Rinehart, Norma Vázquez, Kristopher T Kahle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.222893"}], "href": "https://doi.org/10.1074/jbc.M111.222893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21733846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21733846"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ekatherina Serysheva, Hebist Berhane, Luca Grumolato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2013.88"}], "href": "https://doi.org/10.1038/embor.2013.88"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23797875"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23797875"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chibo Hong, K Scott Moorefield, Peter Jun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0700683104"}], "href": "https://doi.org/10.1073/pnas.0700683104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17578925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17578925"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "S Moniz, F Veríssimo, P Matos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210706"}], "href": "https://doi.org/10.1038/sj.onc.1210706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17667937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17667937"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Peter Jun, Chibo Hong, Anita Lal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1215/15228517-2008-096"}], "href": "https://doi.org/10.1215/15228517-2008-096"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19001526"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19001526"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sónia Moniz, Olga Martinho, Filipe Pinto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/dds405"}], "href": "https://doi.org/10.1093/hmg/dds405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23035050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23035050"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "C Dutruel, F Bergmann, I Rooman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2013.312"}], "href": "https://doi.org/10.1038/onc.2013.312"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23912455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23912455"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Ha Yoon Mo, Seong Won Moon, Chang Hyeok An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regional bias of tumor suppressor gene mutations of STARD8 and WNK2 in colon cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pathol Res Pract (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.prp.2023.155000"}], "href": "https://doi.org/10.1016/j.prp.2023.155000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38091885"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38091885"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Sónia Moniz, Paulo Matos, Peter Jordan "}, {"type": "b", "children": [{"type": "t", "text": "WNK2 modulates MEK1 activity through the Rho GTPase pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2008.06.002"}], "href": "https://doi.org/10.1016/j.cellsig.2008.06.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18593598"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18593598"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Angela Margarida Costa, Filipe Pinto, Olga Martinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.2805"}], "href": "https://doi.org/10.18632/oncotarget.2805"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25596741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25596741"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Li Huang, Xiangyu Liu "}, {"type": "b", "children": [{"type": "t", "text": "microRNA-370 Promotes Cell Growth by Targeting WNK2 in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "DNA Cell Biol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/dna.2018.4602"}], "href": "https://doi.org/10.1089/dna.2018.4602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31009242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31009242"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Ting Xu, Kun Wu, Lei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00858 exerts a tumor-promoting role in colon cancer via HNF4α and WNK2 regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-019-00490-8"}], "href": "https://doi.org/10.1007/s13402-019-00490-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31884577"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31884577"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jiang Du, Yuan Liang, Ji Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Oncol (Dordr) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13402-020-00518-4"}], "href": "https://doi.org/10.1007/s13402-020-00518-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32447640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32447640"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Jinbao Wu, Xianmei Meng, Rui Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00858 inhibits colon cancer cell apoptosis, autophagy, and senescence by activating WNK2 promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2020.112214"}], "href": "https://doi.org/10.1016/j.yexcr.2020.112214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32768499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32768499"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Ana Laura Vieira Alves, Angela Margarida Costa, Olga Martinho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9020485"}], "href": "https://doi.org/10.3390/cells9020485"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32093151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32093151"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tayyab Rehman, Philip H Karp, Andrew L Thurman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Respir Cell Mol Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1165/rcmb.2022-0172OC"}], "href": "https://doi.org/10.1165/rcmb.2022-0172OC"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35849656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35849656"}]}]}]}
Synonyms	NY-CO-43, PRKWNK2, P/OKCL.13, SDCCAG43
Proteins	WNK2_HUMAN
NCBI Gene ID	65268
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

WNK2 has 4,830 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 115 datasets.

Click the + buttons to view associations for WNK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

WNK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WNK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of WNK2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of WNK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of WNK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of WNK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of WNK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of WNK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of WNK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of WNK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with WNK2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with WNK2 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with WNK2 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WNK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of WNK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of WNK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of WNK2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing WNK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing WNK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with WNK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with WNK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of WNK2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with WNK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with WNK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of WNK2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DGIdb Drug Targets 2026	interacting drugs for WNK2 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with WNK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with WNK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with WNK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with WNK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with WNK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at WNK2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of WNK2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of WNK2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing WNK2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with WNK2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with WNK2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing WNK2 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of WNK2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of WNK2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of WNK2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.