{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWNT10A is a pivotal ligand in the canonical Wnt/β‐catenin pathway that governs the development and homeostasis of ectodermal organs. It plays a central role in odontogenesis, hair formation, nail differentiation, and sweat gland development. Functional studies have demonstrated that mutations in WNT10A lead to a broad spectrum of developmental anomalies—including isolated tooth agenesis, oligodontia, and syndromic ectodermal dysplasias such as odonto‐onycho‐dermal dysplasia and Schöpf‐Schulz‐Passarge syndrome—by impairing epithelial progenitor proliferation and disrupting region‐specific differentiation programs. Moreover, common genetic variants in WNT10A are associated with variations in hair morphology and dental crown size, highlighting its pleiotropic effects during embryonic organogenesis and adult tissue maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its developmental roles, aberrant WNT10A signaling has emerged as an important contributor to tumorigenesis and malignant progression. Increased expression or dysregulated activation of WNT10A has been documented in diverse neoplasms—including mantle cell lymphoma, chronic lymphocytic leukemia, renal and esophageal carcinomas, and papillary thyroid cancer—where it promotes cell proliferation, enhances migratory and invasive properties, and confers resistance to apoptosis. These findings implicate WNT10A as a potential autocrine oncogene and underscore its importance in mediating microenvironmental cues that favor cancer progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "27", "end_ref": "34"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, recent investigations have uncovered roles for WNT10A in tissue repair, regeneration, and the modulation of senescent cell populations. In models of joint degeneration and osteoarthritis, WNT10A activity has been linked to improved regenerative microenvironments through the clearance of senescent mesenchymal stem cells. Similar regulatory functions are suggested in conditions affecting the cornea and during hair regrowth in androgenetic alopecia, indicating that controlled activation of WNT10A can influence cell survival and promote restorative processes in adult tissues."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "35", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "T H Beaty, J B Hetmanski, M D Fallin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-006-0235-9"}], "href": "https://doi.org/10.1007/s00439-006-0235-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16953426"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16953426"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lynn Adaimy, Eliane Chouery, Hala Megarbane, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1086/520064"}], "href": "https://doi.org/10.1086/520064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17847007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17847007"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sadia Nawaz, Joakim Klar, Muhammad Wajid, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.81"}], "href": "https://doi.org/10.1038/ejhg.2009.81"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19471313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19471313"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Axel Bohring, Thomas Stamm, Christiane Spaich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2009.06.001"}], "href": "https://doi.org/10.1016/j.ajhg.2009.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19559398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19559398"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicholas Eriksson, J Michael Macpherson, Joyce Y Tung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Web-based, participant-driven studies yield novel genetic associations for common traits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1000993"}], "href": "https://doi.org/10.1371/journal.pgen.1000993"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20585627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20585627"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Céline Cluzeau, Smail Hadj-Rabia, Marguerite Jambou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.21384"}], "href": "https://doi.org/10.1002/humu.21384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20979233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20979233"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marie-José van den Boogaard, Marijn Créton, Yvon Bronkhorst, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in WNT10A are present in more than half of isolated hypodontia cases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2012-100750"}], "href": "https://doi.org/10.1136/jmedgenet-2012-100750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22581971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22581971"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "A Mostowska, B Biedziak, M Zadurska, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleotide variants of genes encoding components of the Wnt signalling pathway and the risk of non-syndromic tooth agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12061"}], "href": "https://doi.org/10.1111/cge.12061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23167694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23167694"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Stefanie Heilmann, Amy K Kiefer, Nadine Fricker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Androgenetic alopecia: identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2013.43"}], "href": "https://doi.org/10.1038/jid.2013.43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23358095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23358095"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shujuan Song, Ruiying Zhao, Huiying He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A variants are associated with non-syndromic tooth agenesis in the general population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-013-1360-x"}], "href": "https://doi.org/10.1007/s00439-013-1360-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24043634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24043634"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "P Kantaputra, M Kaewgahya, W Kantaputra "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A mutations also associated with agenesis of the maxillary permanent canines, a separate entity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36280"}], "href": "https://doi.org/10.1002/ajmg.a.36280"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24311251"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24311251"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Huiying He, Dong Han, Hailan Feng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of and interaction between WNT10A and EDA mutations in tooth agenesis cases in the Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0080393"}], "href": "https://doi.org/10.1371/journal.pone.0080393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24312213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24312213"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Pakeeza Shaiq Arzoo, Joakim Klar, Birgitta Bergendal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A mutations account for ¼ of population-based isolated oligodontia and show phenotypic correlations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36243"}], "href": "https://doi.org/10.1002/ajmg.a.36243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24449199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24449199"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "P Kantaputra, M Kaewgahya, D Jotikasthira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tricho-odonto-onycho-dermal dysplasia and WNT10A mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36388"}], "href": "https://doi.org/10.1002/ajmg.a.36388"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24458874"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24458874"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "M Alves-Ferreira, T Pinho, A Sousa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of genetic risk factors for maxillary lateral incisor agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0022034514523986"}], "href": "https://doi.org/10.1177/0022034514523986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24554542"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24554542"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gabriele Mues, John Bonds, Lilin Xiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The WNT10A gene in ectodermal dysplasias and selective tooth agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.36520"}], "href": "https://doi.org/10.1002/ajmg.a.36520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24700731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24700731"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Birgitta Bergendal, Johanna Norderyd, Xiaolei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormal primary and permanent dentitions with ectodermal symptoms predict WNT10A deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12881-016-0349-4"}], "href": "https://doi.org/10.1186/s12881-016-0349-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27881089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27881089"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "C Tardieu, S Jung, K Niederreither, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dental and extra-oral clinical features in 41 patients with WNT10A gene mutations: A multicentric genotype-phenotype study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12972"}], "href": "https://doi.org/10.1111/cge.12972"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28105635"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28105635"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Mingang Xu, Jeremy Horrell, Melinda Snitow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms15397"}], "href": "https://doi.org/10.1038/ncomms15397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28589954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28589954"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "P N Kantaputra, A Hutsadaloi, M Kaewgahya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10B mutations associated with isolated dental anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13218"}], "href": "https://doi.org/10.1111/cge.13218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29364501"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29364501"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Sonia Magruder, Emily Carter, Meredith A Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orthod Craniofac Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ocr.12248"}], "href": "https://doi.org/10.1111/ocr.12248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30246922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30246922"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Kai Zhao, Meifei Lian, Duohong Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations identified in patients with tooth agenesis by whole-exome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oral Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/odi.13002"}], "href": "https://doi.org/10.1111/odi.13002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30417976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30417976"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Miao Yu, Yang Liu, Haochen Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct impacts of bi-allelic WNT10A mutations on the permanent and primary dentitions in odonto-onycho-dermal dysplasia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.60682"}], "href": "https://doi.org/10.1002/ajmg.a.60682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30569517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30569517"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Asia Parveen, Sher Alam Khan, Muhammad Usman Mirza, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deleterious Variants in "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "WNT10A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ", "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "EDAR,"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "EDA"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Causing Isolated and Syndromic Tooth Agenesis: A Structural Perspective from Molecular Dynamics Simulations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20215282"}], "href": "https://doi.org/10.3390/ijms20215282"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31652981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31652981"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "María Carmen Martínez-Romero, María Juliana Ballesta-Martínez, Vanesa López-González, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EDA, EDAR, EDARADD and WNT10A allelic variants in patients with ectodermal derivative impairment in the Spanish population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Orphanet J Rare Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13023-019-1251-x"}], "href": "https://doi.org/10.1186/s13023-019-1251-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31796081"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31796081"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Y Zeng, E Baugh, S Akyalcin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional Effects of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "WNT10A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Rare Variants Associated with Tooth Agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Dent Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0022034520962728"}], "href": "https://doi.org/10.1177/0022034520962728"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33034246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33034246"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Pascal Gelebart, Mona Anand, Hanan Armanious, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2008-02-139212"}], "href": "https://doi.org/10.1182/blood-2008-02-139212"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18787224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18787224"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ali Memarian, Mohammad Hojjat-Farsangi, Hossein Asgarian-Omran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3109/10428190903331082"}], "href": "https://doi.org/10.3109/10428190903331082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19863181"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19863181"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Yoshihiro Yasuniwa, Hiroto Izumi, Ke-Yong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0015330"}], "href": "https://doi.org/10.1371/journal.pone.0015330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21203463"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21203463"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Rachel L Galbraith, Elizabeth M Poole, David Duggan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polymorphisms in WNT6 and WNT10A and colorectal adenoma risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nutr Cancer (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01635581.2011.542539"}], "href": "https://doi.org/10.1080/01635581.2011.542539"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21547848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21547848"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Ren-Jun Hsu, Jar-Yi Ho, Tai-Lung Cha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0047649"}], "href": "https://doi.org/10.1371/journal.pone.0047649"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23094073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23094073"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Hongman Chen, Yingmei Wang, Fengxia Xue "}, {"type": "b", "children": [{"type": "t", "text": "Expression and the clinical significance of Wnt10a and Wnt10b in endometrial cancer are associated with the Wnt/β-catenin pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2012.2126"}], "href": "https://doi.org/10.3892/or.2012.2126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23135473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23135473"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Apple Long, Véronique Giroux, Kelly A Whelan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A promotes an invasive and self-renewing phenotype in esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgv025"}], "href": "https://doi.org/10.1093/carcin/bgv025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25795715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25795715"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Tianyi Dong, Zhun Zhang, Wenhong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A/β‑catenin pathway in tumorigenesis of papillary thyroid carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5777"}], "href": "https://doi.org/10.3892/or.2017.5777"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28677753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28677753"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Akihiro Kuma, Sohsuke Yamada, Ke-Yong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of WNT10A-expressing kidney fibroblasts in acute interstitial nephritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0103240"}], "href": "https://doi.org/10.1371/journal.pone.0103240"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25054240"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25054240"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Gabriel Cuellar-Partida, Henriët Springelkamp, Sionne E M Lucas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A exonic variant increases the risk of keratoconus by decreasing corneal thickness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddv211"}], "href": "https://doi.org/10.1093/hmg/ddv211"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26049155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26049155"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Dongmei Yu, Yong Shang, Jian Yuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000447896"}], "href": "https://doi.org/10.1159/000447896"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27771714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27771714"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Fujun Yu, XuFei Fan, Bicheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000452509"}], "href": "https://doi.org/10.1159/000452509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27832641"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27832641"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Renqian Du, Nuriye Dinckan, Xiaofei Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-018-1907-y"}], "href": "https://doi.org/10.1007/s00439-018-1907-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30046887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30046887"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "James W Foster, Rupin N Parikh, Jiangxia Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.62.6.16"}], "href": "https://doi.org/10.1167/iovs.62.6.16"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33988693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33988693"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Xu Cao, Xinxing Wang, Wenxiu Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bone (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bone.2021.116006"}], "href": "https://doi.org/10.1016/j.bone.2021.116006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34000432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34000432"}]}]}]}