{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nWTAPP1 is a long noncoding RNA/pseudogene that functions as a key regulatory molecule in endothelial progenitor cells (EPCs), where it acts as a molecular decoy for miR-3120-5p. This decoy mechanism leads to increased expression of MMP-1 and activates the PI3K/Akt/mTOR signaling pathway while concurrently suppressing the autophagy pathway. Together, these effects promote EPC migration, invasion, and tube formation—processes critical for efficient angiogenesis during thrombus events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic ductal adenocarcinoma (PDAC), aberrant N6-methyladenosine (m6A) modification stabilizes WTAPP1 RNA via the CCHC-type zinc finger nucleic-acid binding protein (CNBP). The resulting elevated WTAPP1 binds to its protein-coding counterpart, WTAP mRNA, and recruits the EIF3 translation initiation complex to enhance WTAP protein translation. This upregulation in WTAP then enhances Wnt signaling, thereby contributing to cancer cell proliferation, invasiveness, and overall malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in EPC angiogenesis and pancreatic cancer, WTAPP1 has also been implicated in other malignancies. Preliminary findings suggest that it may participate in the pathogenesis of non‐small cell lung cancer as well as mediate malignant progression in laryngeal cancer. These observations underline a broader function of WTAPP1 in oncogenesis, where it influences cancer cell behavior and disease trajectory."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wen-Dong Li, Dong-Ming Zhou, Li-Li Sun, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WTAPP1 promotes cancer cell invasion and migration in NSCLC by downregulating lncRNA HAND2-AS1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-020-01180-0"}], "href": "https://doi.org/10.1186/s12890-020-01180-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32473628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32473628"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "X-Y Shi, J-J Lin, X-J Ge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA WTAPP1 promotes proliferation of laryngeal carcinoma cells through regulating microRNA-592."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_23038"}], "href": "https://doi.org/10.26355/eurrev_202009_23038"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33015795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33015795"}]}]}]}