XAGE1A Gene

Name X antigen family member 1A
Description This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene, in addition to alternative transcription start sites, results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Summary
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Studies have identified spontaneous CD4+ T‐cell responses against distinct epitopes of XAGE1A—including the immunodominant 33–49 region—and robust IgG responses in affected patients. Moreover, the concomitant expression of XAGE1A with HLA class I molecules has been linked to enhanced CD8+ T‐cell infiltration and improved patient survival, while genetic variations in immunoglobulin allotypes influence the magnitude of the antibody response against the antigen."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond lung cancer, XAGE1A expression is observed in other malignancies. In acute leukemias, for example, XAGE1A mRNA is detectable in both lymphoblastic and myeloid subtypes, and in childhood acute myeloid leukemia, its high expression in peripheral blood samples has been useful for monitoring minimal residual disease and predicting relapse. Furthermore, in colon cancer, the expression of XAGE1A has been associated with a favorable prognosis, suggesting that the antigen’s impact may differ depending on the tumor context."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn adenoid cystic carcinoma, experimental overexpression of XAGE1A enhances tumor cell proliferation, transmembrane invasion, and in vivo metastasis, accompanied by increased tumor angiogenesis. Conversely, knockdown of XAGE1A leads to reduced tumor growth and invasion, providing direct evidence that XAGE1A contributes not only to tumorigenesis but also to the metastatic process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Otavia L Caballero, Tzeela Cohen, Sita Gurung, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Expression and Prognostic Relevance of GAGE1 and XAGE1 Cancer/Testis Antigens in Head and Neck Squamous Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1566524018666180322162145"}], "href": "https://doi.org/10.2174/1566524018666180322162145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29577858"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29577858"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michihide Shimono, Akiko Uenaka, Yuji Noguchi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Microbiol Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1348-0421.2007.tb03965.x"}], "href": "https://doi.org/10.1111/j.1348-0421.2007.tb03965.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17704638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17704638"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Eiki Kikuchi, Koichi Yamazaki, Eiichi Nakayama, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Immun (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18752338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18752338"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Kanako Saito, Eiichi Nakayama, Danila Valmori "}, {"type": "b", "children": [{"type": "t", "text": "Immune Responses to the Cancer Testis Antigen XAGE-1b in Non Small Cell Lung Cancer Caucasian Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0150623"}], "href": "https://doi.org/10.1371/journal.pone.0150623"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26937656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26937656"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "J P Pandey, A M Namboodiri, Y Ohue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants of immunoglobulin γ and κ chains influence humoral immunity to the cancer-testis antigen XAGE-1b (GAGED2a) in patients with non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cei.12247"}], "href": "https://doi.org/10.1111/cei.12247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24304136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24304136"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuqiang Ji, Wanggang Zhang, Jin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "mRNA expression of the XAGE-1 gene in human acute leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Hematol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12185-010-0527-7"}], "href": "https://doi.org/10.1007/s12185-010-0527-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20178013"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20178013"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "N R Hilal, D V Novikov, V V Novikov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Cancer-testis genes in colon cancer]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ter Arkh (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.17116/terarkh2017895113-117"}], "href": "https://doi.org/10.17116/terarkh2017895113-117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28631709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28631709"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Anne-Sofie Skou, Kristian L Juul-Dam, Maria Hansen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Measurable Residual Disease Monitoring of SPAG6, ST18, PRAME, and XAGE1A Expression in Peripheral Blood May Detect Imminent Relapse in Childhood Acute Myeloid Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Diagn (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jmoldx.2021.09.004"}], "href": "https://doi.org/10.1016/j.jmoldx.2021.09.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34600138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34600138"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Bo Zhou, Tingxiu Li, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promoting effects on the proliferation and metastasis of ACC tumor cell with XAGE-1b overexpression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2719"}], "href": "https://doi.org/10.3892/or.2013.2719"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24008415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24008415"}]}]}]}
NCBI Gene ID 653220
API
Download Associations
Predicted Functions View XAGE1A's ARCHS4 Predicted Functions.
Co-expressed Genes View XAGE1A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View XAGE1A's ARCHS4 Predicted Functions.

Functional Associations

XAGE1A has 1,343 functional associations with biological entities spanning 5 categories (functional term, phrase or reference, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets.

Click the + buttons to view associations for XAGE1A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles tissue samples with high or low expression of XAGE1A gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
CM4AI KOLF21J CRISPRi Gene Perturbation Atlas gene perturbations changing expression of XAGE1A gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with XAGE1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with XAGE1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with XAGE1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with XAGE1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of XAGE1A gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
JASPAR Predicted Human Transcription Factor Targets 2025 transcription factors regulating expression of XAGE1A gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of XAGE1A gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of XAGE1A gene from the NIBR DRUG-seq U2OS MoA Box dataset.
Rummagene Transcription Factor Associations 2026 transcription factors regulating expression of XAGE1A gene from the Rummagene Transcription Factor Associations 2026 dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of XAGE1A gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of XAGE1A gene from the RummaGEO Gene Perturbation Signatures dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of XAGE1A protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with XAGE1A protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.