HGNC Family | Exportins (XPO) |
Name | exportin 1 |
Description | This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nExportin 1 (XPO1), also known as chromosomal region maintenance 1 (CRM1), is the principal nuclear export receptor that mediates the transit of proteins, RNAs, and ribonucleoprotein complexes from the nucleus to the cytoplasm. Structural and mechanistic studies have demonstrated that XPO1 recognizes leucine‐rich nuclear export signals (NESs) through a hydrophobic groove in a RanGTP‐dependent manner. High‐resolution X‐ray crystallographic and biochemical analyses have revealed its conformational dynamics and the cooperativity with cofactors such as Ran, Ran-binding proteins, and additional adaptors. These insights underscore the role of XPO1 in governing critical cellular processes including cell cycle regulation, mitotic progression, apoptosis, and stress responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "20"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAlterations in XPO1 function and expression have emerged as hallmarks in the pathogenesis of many human cancers. Aberrant overexpression, mutations, and dysregulated nucleocytoplasmic shuttling of XPO1 can mislocalize key tumor suppressors and regulatory proteins—thereby favoring oncogenic transformation and tumor progression in malignancies such as osteosarcoma, cervical cancer, glioma, pancreatic cancer, and others. Furthermore, investigations have revealed that perturbations in XPO1-mediated export correlate with adverse clinical outcomes, while interplay with pathways regulated by c-Myc and p53 further emphasizes its pathogenic significance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "21", "end_ref": "35"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nExploiting its central role in nuclear export and tumor biology, XPO1 has become an attractive target for anticancer therapy. Novel selective inhibitors of nuclear export (SINE), such as selinexor, have demonstrated the capacity to restore the nuclear localization of aberrantly exported tumor suppressors, trigger apoptosis, and overcome drug resistance in a broad range of malignancies including esophageal squamous cell carcinoma, mantle cell lymphoma, ovarian cancer, and multiple myeloma. Preclinical models and early-phase clinical trials support the potential of XPO1-targeted therapies to not only suppress tumor growth but also improve patient outcomes, thereby laying the groundwork for innovative combinatorial cancer treatment strategies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "36", "end_ref": "45"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ileana Popa, Matthew E Harris, John E Donello, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRM1-dependent function of a cis-acting RNA export element."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.7.2057-2067.2002"}], "href": "https://doi.org/10.1128/MCB.22.7.2057-2067.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11884594"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11884594"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yoshitaka Tajima, Kouichiro Goto, Minoru Yoshida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M212663200"}], "href": "https://doi.org/10.1074/jbc.M212663200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12519765"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12519765"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marshonna Forgues, Michael J Difilippantonio, Steven P Linke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.15.5282-5292.2003"}], "href": "https://doi.org/10.1128/MCB.23.15.5282-5292.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12861014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12861014"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Catherine Julien, Philippe Coulombe, Sylvain Meloche "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302724200"}], "href": "https://doi.org/10.1074/jbc.M302724200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12915405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12915405"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nicola Wiechens, Karolin Heinle, Ludwig Englmeier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nucleo-cytoplasmic shuttling of Axin, a negative regulator of the Wnt-beta-catenin Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307253200"}], "href": "https://doi.org/10.1074/jbc.M307253200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14630927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14630927"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Victor M Brown, Eugene Y Krynetski, Natalia F Krynetskaia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel CRM1-mediated nuclear export signal governs nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase following genotoxic stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307071200"}], "href": "https://doi.org/10.1074/jbc.M307071200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14617633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14617633"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hiroshi Suzuki, Satoshi Tashiro, Shusuke Hira, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600248"}], "href": "https://doi.org/10.1038/sj.emboj.7600248"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15175654"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15175654"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kevin M McBride, Vasco Barreto, Almudena R Ramiro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20040373"}], "href": "https://doi.org/10.1084/jem.20040373"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15117971"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15117971"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Séverine Boulon, Céline Verheggen, Beata E Jady, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2004.11.013"}], "href": "https://doi.org/10.1016/j.molcel.2004.11.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15574332"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15574332"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sten Strunze, Lloyd C Trotman, Karin Boucke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear targeting of adenovirus type 2 requires CRM1-mediated nuclear export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e05-02-0121"}], "href": "https://doi.org/10.1091/mbc.e05-02-0121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15814838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15814838"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alexei Arnaoutov, Yoshiaki Azuma, Katharina Ribbeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crm1 is a mitotic effector of Ran-GTP in somatic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1263"}], "href": "https://doi.org/10.1038/ncb1263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15908946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15908946"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Alexander T Prechtel, Jan Chemnitz, Susann Schirmer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M510306200"}], "href": "https://doi.org/10.1074/jbc.M510306200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16484227"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16484227"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Hui-Wen Lo, Mohamed Ali-Seyed, Yadi Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.20876"}], "href": "https://doi.org/10.1002/jcb.20876"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16552725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16552725"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Rafael Bernad, Dieuwke Engelsma, Helen Sanderson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M512585200"}], "href": "https://doi.org/10.1074/jbc.M512585200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16675447"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16675447"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Saskia Hutten, Ralph H Kehlenbach "}, {"type": "b", "children": [{"type": "t", "text": "Nup214 is required for CRM1-dependent nuclear protein export in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00342-06"}], "href": "https://doi.org/10.1128/MCB.00342-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16943420"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16943420"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Shirley K Knauer, Carolin Bier, Negusse Habtemichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7400824"}], "href": "https://doi.org/10.1038/sj.embor.7400824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17099693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17099693"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Roland H Stauber, Wolf Mann, Shirley K Knauer "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear and cytoplasmic survivin: molecular mechanism, prognostic, and therapeutic potential."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-0494"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-0494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17616652"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17616652"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Julia Dorfman, Ian G Macara "}, {"type": "b", "children": [{"type": "t", "text": "STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-05-0454"}], "href": "https://doi.org/10.1091/mbc.e07-05-0454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18256292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18256292"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Haruhiko Sakiyama, R Max Wynn, Wan-Ru Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804308200"}], "href": "https://doi.org/10.1074/jbc.M804308200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18606808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18606808"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Ilias Mylonis, Georgia Chachami, Efrosyni Paraskeva, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1alpha by MAPK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M803081200"}], "href": "https://doi.org/10.1074/jbc.M803081200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18687685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18687685"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Yang Yao, Yang Dong, Feng Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expression of CRM1 is associated with prognosis in human osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19082467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19082467"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Pauline J van der Watt, Christopher P Maske, Denver T Hendricks, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Karyopherin proteins, Crm1 and Karyopherin beta1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.24146"}], "href": "https://doi.org/10.1002/ijc.24146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19117056"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19117056"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xiuhua Dong, Anindita Biswas, Yuh Min Chook "}, {"type": "b", "children": [{"type": "t", "text": "Structural basis for assembly and disassembly of the CRM1 nuclear export complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Struct Mol Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nsmb.1586"}], "href": "https://doi.org/10.1038/nsmb.1586"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19339972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19339972"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Aiguo Shen, Yuchan Wang, Yueming Zhao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurosurgery (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1227/01.NEU.0000348550.47441.4B"}], "href": "https://doi.org/10.1227/01.NEU.0000348550.47441.4B"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19574837"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19574837"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Noah Crampton, Mohamed Kodiha, Sanhita Shrivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress inhibits nuclear protein export by multiple mechanisms that target FG nucleoporins and Crm1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e09-05-0397"}], "href": "https://doi.org/10.1091/mbc.e09-05-0397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19828735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19828735"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Wei-yi Huang, Lu Yue, Wen-shen Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic value of CRM1 in pancreas cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Invest Med (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20003838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20003838"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Lior Golomb, Debora Rosa Bublik, Sylvia Wilder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Importin 7 and exportin 1 link c-Myc and p53 to regulation of ribosomal biogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2011.11.022"}], "href": "https://doi.org/10.1016/j.molcel.2011.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22284678"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22284678"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Parvathi Ranganathan, Xueyan Yu, Caroline Na, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-04-423160"}], "href": "https://doi.org/10.1182/blood-2012-04-423160"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22677130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22677130"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Rosa Lapalombella, Qingxiang Sun, Katie Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-05-429506"}], "href": "https://doi.org/10.1182/blood-2012-05-429506"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23034282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23034282"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Ketan Thakar, Samir Karaca, Sarah A Port, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of CRM1-dependent Nuclear Export Cargos Using Quantitative Mass Spectrometry."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M112.024877"}], "href": "https://doi.org/10.1074/mcp.M112.024877"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23242554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23242554"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Kensuke Kojima, Steven M Kornblau, Vivian Ruvolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic impact and targeting of CRM1 in acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-08-447581"}], "href": "https://doi.org/10.1182/blood-2012-08-447581"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23564911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23564911"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Y-T Tai, Y Landesman, C Acharya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2013.115"}], "href": "https://doi.org/10.1038/leu.2013.115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23588715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23588715"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "J Schmidt, E Braggio, K M Kortuem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2013.172"}], "href": "https://doi.org/10.1038/leu.2013.172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23752175"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23752175"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "S Jeromin, S Weissmann, C Haferlach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SF3B1 mutations correlated to cytogenetics and mutations in NOTCH1, FBXW7, MYD88, XPO1 and TP53 in 1160 untreated CLL patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2013.263"}], "href": "https://doi.org/10.1038/leu.2013.263"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24113472"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24113472"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yan Cheng, Michael P Holloway, Kevin Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Ther (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1535-7163.MCT-13-0416"}], "href": "https://doi.org/10.1158/1535-7163.MCT-13-0416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24431073"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24431073"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "De-Chen Lin, Jia-Jie Hao, Yasunobu Nagata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic and molecular characterization of esophageal squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.2935"}], "href": "https://doi.org/10.1038/ng.2935"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24686850"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24686850"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Mariko Yoshimura, Jo Ishizawa, Vivian Ruvolo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.12430"}], "href": "https://doi.org/10.1111/cas.12430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24766216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24766216"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "Jo Ishizawa, Kensuke Kojima, Numsen Hail, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pharmacol Ther (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.pharmthera.2015.06.001"}], "href": "https://doi.org/10.1016/j.pharmthera.2015.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26048327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26048327"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Tobias Ritterhoff, Hrishikesh Das, Götz Hofhaus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms11482"}], "href": "https://doi.org/10.1038/ncomms11482"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27160050"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27160050"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Parvathi Ranganathan, Trinayan Kashyap, Xueyan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XPO1 Inhibition using Selinexor Synergizes with Chemotherapy in Acute Myeloid Leukemia by Targeting DNA Repair and Restoring Topoisomerase IIα to the Nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-15-2885"}], "href": "https://doi.org/10.1158/1078-0432.CCR-15-2885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27358488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27358488"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Fabrice Jardin, Anais Pujals, Laura Pelletier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recurrent mutations of the exportin 1 gene (XPO1) and their impact on selective inhibitor of nuclear export compounds sensitivity in primary mediastinal B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hematol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajh.24451"}], "href": "https://doi.org/10.1002/ajh.24451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27312795"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27312795"}]}, {"type": "r", "ref": 42, "children": [{"type": "t", "text": "Vincent Camus, Aspasia Stamatoullas, Sylvain Mareschal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection and prognostic value of recurrent exportin 1 mutations in tumor and cell-free circulating DNA of patients with classical Hodgkin lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Haematologica (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3324/haematol.2016.145102"}], "href": "https://doi.org/10.3324/haematol.2016.145102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27479820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27479820"}]}, {"type": "r", "ref": 43, "children": [{"type": "t", "text": "Ying Chen, Sandra Catalina Camacho, Thomas R Silvers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the Nuclear Export Receptor XPO1 as a Therapeutic Target for Platinum-Resistant Ovarian Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1078-0432.CCR-16-1333"}], "href": "https://doi.org/10.1158/1078-0432.CCR-16-1333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27649553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27649553"}]}, {"type": "r", "ref": 44, "children": [{"type": "t", "text": "Joel G Turner, Trinayan Kashyap, Jana L Dawson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XPO1 inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IκBα and overcomes acquired proteasome inhibitor resistance in human multiple myeloma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12969"}], "href": "https://doi.org/10.18632/oncotarget.12969"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27806331"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27806331"}]}, {"type": "r", "ref": 45, "children": [{"type": "t", "text": "Asfar S Azmi, Mohammed H Uddin, Ramzi M Mohammad "}, {"type": "b", "children": [{"type": "t", "text": "The nuclear export protein XPO1 - from biology to targeted therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Rev Clin Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41571-020-00442-4"}], "href": "https://doi.org/10.1038/s41571-020-00442-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33173198"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33173198"}]}]}]}
|
Synonyms | EXP1, emb, CRM1 |
Proteins | XPO1_HUMAN |
NCBI Gene ID | 7514 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
XPO1 has 12,718 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 123 datasets.
Click the + buttons to view associations for XPO1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of XPO1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of XPO1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of XPO1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of XPO1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of XPO1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
Biocarta Pathways | pathways involving XPO1 protein from the Biocarta Pathways dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of XPO1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of XPO1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of XPO1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with XPO1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with XPO1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of XPO1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of XPO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of XPO1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of XPO1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing XPO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing XPO1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing XPO1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 | cellular components containing XPO1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with XPO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with XPO1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing XPO1 protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of XPO1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with XPO1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with XPO1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with XPO1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with XPO1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of XPO1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with XPO1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with XPO1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with XPO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with XPO1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with XPO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with XPO1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at XPO1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of XPO1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of XPO1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing XPO1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD High Level Gene-Disease Associations | diseases associated with XPO1 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with XPO1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing XPO1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of XPO1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving XPO1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving XPO1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving XPO1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing XPO1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing XPO1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing XPO1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by XPO1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of XPO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of XPO1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of XPO1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GWASdb SNP-Disease Associations | diseases associated with XPO1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with XPO1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for XPO1 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of XPO1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of XPO1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of XPO1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of XPO1 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for XPO1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with XPO1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by XPO1 gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for XPO1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of XPO1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate XPO1 protein from the curated KEA Substrates of Kinases dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate XPO1 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of XPO1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of XPO1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with XPO1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of XPO1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of XPO1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of XPO1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of XPO1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing XPO1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain XPO1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by XPO1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting XPO1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of XPO1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MSigDB Cancer Gene Co-expression Modules | co-expressed genes for XPO1 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of XPO1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of XPO1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing XPO1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
NURSA Protein-Protein Interactions | interacting proteins for XPO1 from the NURSA Protein-Protein Interactions dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for XPO1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of XPO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of XPO1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving XPO1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving XPO1 protein from the Wikipathways PFOCR 2024 dataset. | |
Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with XPO1 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate XPO1 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
PID Pathways | pathways involving XPO1 protein from the PID Pathways dataset. | |
ProteomicsDB Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of XPO1 protein relative to other cell types and tissues from the ProteomicsDB Cell Type and Tissue Protein Expression Profiles dataset. | |
Reactome Pathways 2014 | pathways involving XPO1 protein from the Reactome Pathways dataset. | |
Reactome Pathways 2024 | pathways involving XPO1 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of XPO1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of XPO1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of XPO1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of XPO1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at XPO1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of XPO1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of XPO1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Sanger Dependency Map Cancer Cell Line Proteomics | cell lines associated with XPO1 protein from the Sanger Dependency Map Cancer Cell Line Proteomics dataset. | |
SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of XPO1 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of XPO1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of XPO1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of XPO1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of XPO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of XPO1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of XPO1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of XPO1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with XPO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with XPO1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2024 | pathways involving XPO1 protein from the WikiPathways Pathways 2024 dataset. | |