XPO7 Gene

HGNC Family	Exportins (XPO)
Name	exportin 7
Description	The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-16 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nXPO7 is a versatile bidirectional nuclear transport receptor that mediates the movement of a broad range of cargoes between the nucleus and cytoplasm. In partnership with adaptor proteins such as STRADα, XPO7 facilitates the nuclear export of key signaling molecules like LKB1, thereby influencing cell polarity, metabolism, and growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, XPO7 participates in alternative nuclear import routes: it has been shown to bind NF‑κB/p65 when its canonical nuclear localization signal is mutated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In addition, it directly exports substrates such as p50RhoGAP and 14‑3‑3σ by recognizing unique, conformational export signals that differ fundamentally from CRM1‐dependent leucine‐rich signals"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", and comprehensive cargo profiling further established its capacity to shuttle both export and import cargos"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", which is also reflected in the nuclear export of the thyroid hormone receptor in conjunction with other exportins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its transport functions, XPO7 is emerging as a regulator of transcriptional activity and cellular homeostasis. The interaction of XPO7 (also known as RANBP16) with basic helix–loop–helix transcription factors such as E12/E47 enhances E2A-dependent transactivation and upregulates cyclin-dependent kinase inhibitors like p21, implicating it in cell cycle control."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In tumor cells, mutant forms of XPO7 have been observed to alter cell proliferation and migration profiles"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", while its depletion interferes with senescence programs by reducing TCF3 levels and impairing p21^CIP1 induction, supporting its role as a tumor suppressor in oncogene-induced senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe clinical relevance of XPO7 is underscored by its aberrant expression in various cancers and its genetic regulation. High RAN expression, which is intricately linked to nucleo‐cytoplasmic transport dynamics, correlates with aggressive disease in ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and abnormal XPO7 levels have also been noted in prostate cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": " In a different context, a single nucleotide polymorphism (rs80207740) that modulates an erythroid‐specific enhancer has been shown to affect IKZF1 binding and consequently drive XPO7 expression; knockout models of XPO7 exhibit anemic phenotypes characterized by decreased red blood cell volume and hemoglobin levels."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Julia Dorfman, Ian G Macara "}, {"type": "b", "children": [{"type": "t", "text": "STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e07-05-0454"}], "href": "https://doi.org/10.1091/mbc.e07-05-0454"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18256292"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18256292"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Peizhou Liang, Haiyan Zhang, Guoxin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "KPNB1, XPO7 and IPO8 mediate the translocation ofNF-κB/p65 into the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/tra.12097"}], "href": "https://doi.org/10.1111/tra.12097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23906023"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23906023"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "José-Manuel Mingot, Markus T Bohnsack, Ursula Jäkle, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exportin 7 defines a novel general nuclear export pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.emboj.7600338"}], "href": "https://doi.org/10.1038/sj.emboj.7600338"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15282546"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15282546"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Metin Aksu, Tino Pleiner, Samir Karaca, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Xpo7 is a broad-spectrum exportin and a nuclear import receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.201712013"}], "href": "https://doi.org/10.1083/jcb.201712013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29748336"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29748336"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Kelly S Subramanian, Rose C Dziedzic, Hallie N Nelson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple exportins influence thyroid hormone receptor localization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Endocrinol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mce.2015.04.014"}], "href": "https://doi.org/10.1016/j.mce.2015.04.014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25911113"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25911113"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jun-Ho Lee, Shengli Zhou, Cynthia M Smas "}, {"type": "b", "children": [{"type": "t", "text": "Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.22689"}], "href": "https://doi.org/10.1002/jcb.22689"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20503194"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20503194"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lale Erdem-Eraslan, Daphne Heijsman, Maurice de Wit, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-specific mutations in low-frequency genes affect their functional properties."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurooncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11060-015-1741-1"}], "href": "https://doi.org/10.1007/s11060-015-1741-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25694352"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25694352"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Andrew J Innes, Bin Sun, Verena Wagner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XPO7 is a tumor suppressor regulating p21"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "CIP1"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-dependent senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.343269.120"}], "href": "https://doi.org/10.1101/gad.343269.120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33602872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33602872"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Katia Y Cáceres-Gorriti, Euridice Carmona, Véronique Barrès, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RAN nucleo-cytoplasmic transport and mitotic spindle assembly partners XPO7 and TPX2 are new prognostic biomarkers in serous epithelial ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0091000"}], "href": "https://doi.org/10.1371/journal.pone.0091000"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24625450"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24625450"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yu Lin, Ming Zhan, Bin Xu "}, {"type": "b", "children": [{"type": "t", "text": "Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-04705-2"}], "href": "https://doi.org/10.1007/s00432-023-04705-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37000263"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37000263"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xinjun Hu, Jiaxin Wang, Ke Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The GWAS SNP rs80207740 modulates erythrocyte traits via allele-specific binding of IKZF1 and targeting XPO7 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202302017R"}], "href": "https://doi.org/10.1096/fj.202302017R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38780091"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38780091"}]}]}]}
Synonyms	RANBP16, EXP7
Proteins	XPO7_HUMAN
NCBI Gene ID	23039
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

XPO7 has 9,216 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for XPO7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

XPO7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of XPO7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of XPO7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of XPO7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of XPO7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of XPO7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of XPO7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of XPO7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of XPO7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of XPO7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of XPO7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of XPO7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of XPO7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with XPO7 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of XPO7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of XPO7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of XPO7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of XPO7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing XPO7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing XPO7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with XPO7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with XPO7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of XPO7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with XPO7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with XPO7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with XPO7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with XPO7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by XPO7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with XPO7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with XPO7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with XPO7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with XPO7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with XPO7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at XPO7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of XPO7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of XPO7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing XPO7 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with XPO7 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with XPO7 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of XPO7 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with XPO7 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.