ZBTB18 Gene

HGNC Family	Zinc fingers, BTB (POZ) domain containing (BTBD)
Name	zinc finger and BTB domain containing 18
Description	This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZBTB18, also known as RP58 or ZNF238, is a zinc‐finger transcriptional repressor that plays a critical role in mammalian brain development by ensuring the timely differentiation of neural precursors. It acts by repressing key proneurogenic genes (such as pax6, ngn2 and neuroD1), thereby promoting the exit of neuronal progenitors from the cell cycle and favoring their maturation into postmitotic neurons. Loss or diminished expression of ZBTB18 disrupts this balance, leading to an accumulation of immature precursors and manifesting in developmental defects such as microencephaly, abnormalities of the corpus callosum, and intellectual disability. In patients with 1q43q44 microdeletions and in mouse models, haploinsufficiency or dysfunction of ZBTB18 is associated with these neurodevelopmental phenotypes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "8"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its developmental functions, ZBTB18 serves as an important tumor suppressor in brain malignancies such as medulloblastoma and glioblastoma. In these tumors, ZBTB18 is typically expressed at low levels or silenced via promoter hypermethylation, a loss that correlates with enhanced proliferation, an aggressive mesenchymal phenotype, and resistance to conventional therapies. Re‐expression of ZBTB18 in tumor cells restores cell cycle arrest, promotes differentiation and apoptosis, and concomitantly alters oncogenic signaling pathways by engaging co‐repressors like CtBP2 and LSD1. These interactions ultimately modulate metabolic processes including fatty acid synthesis and PI3K signaling, thereby limiting tumor growth."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural and functional studies have further illuminated how genetic variants in ZBTB18 underpin neurodevelopmental disorders. In silico modeling and structure‐based analyses reveal that both de novo and inherited missense as well as truncating mutations frequently disrupt the zinc finger domain, impairing its sequence‐specific DNA binding capacity. These mutations compromise the formation of essential transcriptional repressive complexes – for instance, by altering interactions at E‐box binding sites – and thereby lead to aberrant gene regulatory activities that impair neuronal migration and circuit formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "C Xiang, V Baubet, S Pal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2011.144"}], "href": "https://doi.org/10.1038/cdd.2011.144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22095278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22095278"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Christel Depienne, Caroline Nava, Boris Keren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and phenotypic dissection of 1q43q44 microdeletion syndrome and neurodevelopmental phenotypes associated with mutations in ZBTB18 and HNRNPU."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-017-1772-0"}], "href": "https://doi.org/10.1007/s00439-017-1772-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28283832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28283832"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "J S Cohen, S Srivastava, K D Farwell Hagman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Further evidence that de novo missense and truncating variants in ZBTB18 cause intellectual disability with variable features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.12861"}], "href": "https://doi.org/10.1111/cge.12861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27598823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27598823"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Isabel A Hemming, Olivier Clément, Ivan E Gladwyn-Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disease-associated missense variants in ZBTB18 disrupt DNA binding and impair the development of neurons within the embryonic cerebral cortex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.23803"}], "href": "https://doi.org/10.1002/humu.23803"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31112317"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31112317"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Julian I-T Heng, Leon Viti, Kye Pugh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Understanding the impact of ZBTB18 missense variation on transcription factor function in neurodevelopment and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jnc.15572"}], "href": "https://doi.org/10.1111/jnc.15572"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35083747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35083747"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nadja Ehmke, Sylvio Karge, Johannes Buchmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A de novo nonsense mutation in ZBTB18 plus a de novo 15q13.3 microdeletion in a 6-year-old female."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.38145"}], "href": "https://doi.org/10.1002/ajmg.a.38145"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28345786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28345786"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nana Li, Hong Kang, Yanna Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel heterozygous ZBTB18 missense mutation in a family with non-syndromic intellectual disability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-023-00727-7"}], "href": "https://doi.org/10.1007/s10048-023-00727-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37525067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37525067"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Alejandro J Brea-Fernández, Federica A Souto-Trinei, Elba Iglesias, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expanding the Clinical and Molecular Spectrum of FOXG1- and ZBTB18-Associated Neurodevelopmental Disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cytogenet Genome Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000535660"}], "href": "https://doi.org/10.1159/000535660"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38056433"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38056433"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Valérie M Tatard, Chaomei Xiang, Jaclyn A Biegel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF238 is expressed in postmitotic brain cells and inhibits brain tumor growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-2249"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-2249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20103640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20103640"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Vita Fedele, Fangping Dai, Anie P Masilamani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-16-0494"}], "href": "https://doi.org/10.1158/1541-7786.MCR-16-0494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28512252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28512252"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Liang Chen, Lu Wang, Jun Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CtBP2 interacts with ZBTB18 to promote malignancy of glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lfs.2020.118477"}], "href": "https://doi.org/10.1016/j.lfs.2020.118477"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32971103"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32971103"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sarah Bazzocco, Higinio Dopeso, Águeda Martínez-Barriocanal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Epigenetics (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13148-021-01070-0"}], "href": "https://doi.org/10.1186/s13148-021-01070-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33892786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33892786"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Roberto Ferrarese, Annalisa Izzo, Geoffroy Andrieux, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Life Sci Alliance (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26508/lsa.202201400"}], "href": "https://doi.org/10.26508/lsa.202201400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36414381"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36414381"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Bin Xie, Tariq E Khoyratty, Enas Abu-Shah, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.2000367"}], "href": "https://doi.org/10.4049/jimmunol.2000367"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33608456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33608456"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Isabel A Hemming, Steven Blake, Mark Agostino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "General population ZBTB18 missense variants influence DNA binding and transcriptional regulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.24069"}], "href": "https://doi.org/10.1002/humu.24069"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32598555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32598555"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Steven Blake, Isabel Hemming, Julian Ik-Tsen Heng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structure-Based Approaches to Classify the Functional Impact of ZBTB18 Missense Variants in Health and Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Chem Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acschemneuro.0c00758"}], "href": "https://doi.org/10.1021/acschemneuro.0c00758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33621064"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33621064"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Mark N Cruickshank, James Dods, Rhonda L Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2015.03.016"}], "href": "https://doi.org/10.1016/j.biocel.2015.03.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25817480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25817480"}]}]}]}
Synonyms	ZNF238, RP58, TAZ-1, C2H2-171, MRD22
Proteins	ZBT18_HUMAN
NCBI Gene ID	10472
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZBTB18 has 8,810 functional associations with biological entities spanning 7 categories (molecular profile, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 105 datasets.

Click the + buttons to view associations for ZBTB18 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZBTB18 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZBTB18 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZBTB18 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZBTB18 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZBTB18 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZBTB18 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZBTB18 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZBTB18 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZBTB18 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZBTB18 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZBTB18 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZBTB18 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZBTB18 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ZBTB18 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZBTB18 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZBTB18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZBTB18 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ZBTB18 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ZBTB18 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZBTB18 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZBTB18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ZBTB18 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing ZBTB18 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZBTB18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZBTB18 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZBTB18 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZBTB18 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ZBTB18 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ZBTB18 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ZBTB18 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ZBTB18 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ZBTB18 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZBTB18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZBTB18 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZBTB18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ZBTB18 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZBTB18 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZBTB18 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZBTB18 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ZBTB18 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ZBTB18 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.