HGNC Family | Homeoboxes, Zinc fingers |
Name | zinc finger E-box binding homeobox 1 |
Description | This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010] |
Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZEB1 is a pivotal transcription factor that orchestrates epithelial‐to‐mesenchymal transition (EMT) by directly repressing key epithelial markers such as E‐cadherin and critical cell–cell adhesion and polarity genes. Its up‐regulation in a variety of cancers—including breast, colorectal, pancreatic, and lung carcinomas—is strongly associated with dedifferentiation, increased motility, invasiveness, and ultimately metastatic dissemination, thereby contributing to poor clinical outcomes. This early role of ZEB1 in driving the mesenchymal phenotype is underscored by its direct transcriptional repression of epithelial determinants and its correlation with tumor progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "15"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nZEB1 is intricately regulated by microRNAs—most notably the miR-200 family and miR-205—that form reciprocal feedback loops with it to fine-tune the balance between epithelial and mesenchymal states. Attenuation or loss of these microRNAs leads to sustained high levels of ZEB1, which not only reinforces EMT but also promotes tumor-initiating properties, stemness, drug resistance, and radioresistance across multiple cancer types. In addition, ZEB1 modulates key signaling pathways such as those mediated by transforming growth factor-β (TGF-β) and p53, integrating diverse upstream signals to further drive malignant progression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "31"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its cell‐intrinsic effects, ZEB1 critically shapes the tumor microenvironment. It orchestrates interactions that lead to remodeling of the extracellular matrix—such as enhanced collagen deposition and crosslinking via lysyl oxidase family members—and activates downstream kinases (e.g., FAK/SRC) that further potentiate invasion and metastatic spread. Moreover, ZEB1 can collaborate with other transcriptional regulators (for example, partnering with YAP to act as a co-activator) and respond to stimuli from hypoxic and inflammatory conditions, thereby enabling tumor cells to adapt dynamically to environmental cues. Collectively, these multifaceted roles designate ZEB1 not only as a master inducer of EMT but also as a central hub integrating signals that promote tumor aggressiveness, metastasis, and therapeutic resistance—rendering it a promising target for future clinical interventions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "32", "end_ref": "41"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra Guaita, Isabel Puig, Clara Franci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206400200"}], "href": "https://doi.org/10.1074/jbc.M206400200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12161443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12161443"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Antonio A Postigo "}, {"type": "b", "children": [{"type": "t", "text": "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg225"}], "href": "https://doi.org/10.1093/emboj/cdg225"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12743038"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12743038"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Antonio A Postigo, Jennifer L Depp, Jennifer J Taylor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg226"}], "href": "https://doi.org/10.1093/emboj/cdg226"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12743039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12743039"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Simone Spaderna, Otto Schmalhofer, Falk Hlubek, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2006.06.016"}], "href": "https://doi.org/10.1053/j.gastro.2006.06.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16952552"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16952552"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "K Aigner, B Dampier, L Descovich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210508"}], "href": "https://doi.org/10.1038/sj.onc.1210508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17486063"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17486063"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Simone Spaderna, Otto Schmalhofer, Mandy Wahlbuhl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-07-5682"}], "href": "https://doi.org/10.1158/0008-5472.CAN-07-5682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18199550"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18199550"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Philip A Gregory, Andrew G Bert, Emily L Paterson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1722"}], "href": "https://doi.org/10.1038/ncb1722"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18376396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18376396"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Manav Korpal, Esther S Lee, Guohong Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C800074200"}], "href": "https://doi.org/10.1074/jbc.C800074200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18411277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18411277"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ulrike Burk, Jörg Schubert, Ulrich Wellner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/embor.2008.74"}], "href": "https://doi.org/10.1038/embor.2008.74"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18483486"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18483486"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Cameron P Bracken, Philip A Gregory, Natasha Kolesnikoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-1942"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-1942"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18829540"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18829540"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Otto Schmalhofer, Simone Brabletz, Thomas Brabletz "}, {"type": "b", "children": [{"type": "t", "text": "E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Metastasis Rev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10555-008-9179-y"}], "href": "https://doi.org/10.1007/s10555-008-9179-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19153669"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19153669"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Justin M Drake, Garth Strohbehn, Thomas B Bair, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.e08-10-1076"}], "href": "https://doi.org/10.1091/mbc.e08-10-1076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19225155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19225155"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thiruvengadam Arumugam, Vijaya Ramachandran, Keith F Fournier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-08-2819"}], "href": "https://doi.org/10.1158/0008-5472.CAN-08-2819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19584296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19584296"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ulrich Wellner, Jörg Schubert, Ulrike C Burk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1998"}], "href": "https://doi.org/10.1038/ncb1998"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19935649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19935649"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "E Sánchez-Tilló, A Lázaro, R Torrent, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.102"}], "href": "https://doi.org/10.1038/onc.2010.102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20418909"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20418909"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Nora E Renthal, Chien-Cheng Chen, Koriand'r C Williams, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1008301107"}], "href": "https://doi.org/10.1073/pnas.1008301107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21079000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21079000"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Simone Brabletz, Karolina Bajdak, Simone Meidhof, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2010.349"}], "href": "https://doi.org/10.1038/emboj.2010.349"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21224848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21224848"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Natàlia Dave, Sandra Guaita-Esteruelas, Susana Gutarra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.168625"}], "href": "https://doi.org/10.1074/jbc.M110.168625"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21317430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21317430"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Philip A Gregory, Cameron P Bracken, Eric Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E11-02-0103"}], "href": "https://doi.org/10.1091/mbc.E11-02-0103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21411626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21411626"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Taewan Kim, Angelo Veronese, Flavia Pichiorri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p53 regulates epithelial-mesenchymal transition through microRNAs targeting ZEB1 and ZEB2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20110235"}], "href": "https://doi.org/10.1084/jem.20110235"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21518799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21518799"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "A Magenta, C Cencioni, P Fasanaro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2011.42"}], "href": "https://doi.org/10.1038/cdd.2011.42"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21527937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21527937"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Ester Sánchez-Tilló, Oriol de Barrios, Laura Siles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "β-catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1108977108"}], "href": "https://doi.org/10.1073/pnas.1108977108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22080605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22080605"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Hua Xiong, Jie Hong, Wan Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.295964"}], "href": "https://doi.org/10.1074/jbc.M111.295964"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22205702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22205702"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "P Dong, M Karaayvaz, N Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.334"}], "href": "https://doi.org/10.1038/onc.2012.334"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22847613"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22847613"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Ningning Cong, Ping Du, Anling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2013.2267"}], "href": "https://doi.org/10.3892/or.2013.2267"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23381389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23381389"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Florian A Siebzehnrubl, Daniel J Silver, Bugra Tugertimur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/emmm.201302827"}], "href": "https://doi.org/10.1002/emmm.201302827"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23818228"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23818228"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Christine L Chaffer, Nemanja D Marjanovic, Tony Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2013.06.005"}], "href": "https://doi.org/10.1016/j.cell.2013.06.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23827675"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23827675"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Yunshan Wang, Mingxin Wen, Yongwon Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CUL4A induces epithelial-mesenchymal transition and promotes cancer metastasis by regulating ZEB1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-13-2182"}], "href": "https://doi.org/10.1158/0008-5472.CAN-13-2182"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24305877"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24305877"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Wen-Dong Bai, Xing-Ming Ye, Meng-Yao Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-200c suppresses TGF-β signaling and counteracts trastuzumab resistance and metastasis by targeting ZNF217 and ZEB1 in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28782"}], "href": "https://doi.org/10.1002/ijc.28782"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24615544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24615544"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Peijing Zhang, Yongkun Wei, Li Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb3013"}], "href": "https://doi.org/10.1038/ncb3013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25086746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25086746"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "J V Joseph, S Conroy, T Tomar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.395"}], "href": "https://doi.org/10.1038/cddis.2014.395"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25275602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25275602"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Wenjing Zhang, Xinpeng Shi, Ying Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HIF-1α Promotes Epithelial-Mesenchymal Transition and Metastasis through Direct Regulation of ZEB1 in Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0129603"}], "href": "https://doi.org/10.1371/journal.pone.0129603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26057751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26057751"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Bogdan-Tiberius Preca, Karolina Bajdak, Kerstin Mock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A self-enforcing CD44s/ZEB1 feedback loop maintains EMT and stemness properties in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.29642"}], "href": "https://doi.org/10.1002/ijc.29642"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26077342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26077342"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Linghua Wang, Xiao Ni, Kyle R Covington, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3444"}], "href": "https://doi.org/10.1038/ng.3444"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26551670"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26551670"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Yaoyong Lu, Tao Li, Ganbao Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The long non-coding RNA NEAT1 regulates epithelial to mesenchymal transition and radioresistance in through miR-204/ZEB1 axis in nasopharyngeal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4773-4"}], "href": "https://doi.org/10.1007/s13277-015-4773-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27020592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27020592"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Shi-Peng Li, Hai-Xu Xu, Yao Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.9883"}], "href": "https://doi.org/10.18632/oncotarget.9883"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27285757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27285757"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Jill E Larsen, Vaishnavi Nathan, Jihan K Osborne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1 drives epithelial-to-mesenchymal transition in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI76725"}], "href": "https://doi.org/10.1172/JCI76725"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27500490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27500490"}]}, {"type": "r", "ref": 38, "children": [{"type": "t", "text": "D H Peng, C Ungewiss, P Tong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2016.358"}], "href": "https://doi.org/10.1038/onc.2016.358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27694892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27694892"}]}, {"type": "r", "ref": 39, "children": [{"type": "t", "text": "Julie Caramel, Maud Ligier, Alain Puisieux "}, {"type": "b", "children": [{"type": "t", "text": "Pleiotropic Roles for ZEB1 in Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-17-2476"}], "href": "https://doi.org/10.1158/0008-5472.CAN-17-2476"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29254997"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29254997"}]}, {"type": "r", "ref": 40, "children": [{"type": "t", "text": "Shi-Jiang Deng, Heng-Yu Chen, Zeng Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hypoxia-induced LncRNA-BX111 promotes metastasis and progression of pancreatic cancer through regulating ZEB1 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-018-0382-1"}], "href": "https://doi.org/10.1038/s41388-018-0382-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29970904"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29970904"}]}, {"type": "r", "ref": 41, "children": [{"type": "t", "text": "Yingmin Wu, Xiangling Yang, Zhuojia Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1014-2"}], "href": "https://doi.org/10.1186/s12943-019-1014-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30979372"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30979372"}]}]}]}
|
Synonyms | AREB6, BZP, PPCD3, TCF8, NIL2A, DELTAEF1, FECD6, ZFHEP, ZFHX1A |
Proteins | ZEB1_HUMAN |
NCBI Gene ID | 6935 |
API | |
Download Associations | |
Predicted Functions |
![]() |
Co-expressed Genes |
![]() |
Expression in Tissues and Cell Lines |
![]() |
ZEB1 has 12,284 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.
Click the + buttons to view associations for ZEB1 from the datasets below.
If available, associations are ranked by standardized value
Dataset | Summary | |
---|---|---|
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZEB1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZEB1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZEB1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
Biocarta Pathways | pathways involving ZEB1 protein from the Biocarta Pathways dataset. | |
BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZEB1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZEB1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZEB1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
CCLE Cell Line Proteomics | Cell lines associated with ZEB1 protein from the CCLE Cell Line Proteomics dataset. | |
CellMarker Gene-Cell Type Associations | cell types associated with ZEB1 gene from the CellMarker Gene-Cell Type Associations dataset. | |
ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZEB1 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
ChEA Transcription Factor Targets | transcription factors binding the promoter of ZEB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZEB1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
ClinVar Gene-Phenotype Associations | phenotypes associated with ZEB1 gene from the curated ClinVar Gene-Phenotype Associations dataset. | |
CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZEB1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZEB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing ZEB1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing ZEB1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with ZEB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZEB1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
CORUM Protein Complexes | protein complexs containing ZEB1 protein from the CORUM Protein Complexes dataset. | |
COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZEB1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
COSMIC Cell Line Gene Mutation Profiles | cell lines with ZEB1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
CTD Gene-Chemical Interactions | chemicals interacting with ZEB1 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
CTD Gene-Disease Associations | diseases associated with ZEB1 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
dbGAP Gene-Trait Associations | traits associated with ZEB1 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of ZEB1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZEB1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
DISEASES Curated Gene-Disease Association Evidence Scores 2025 | diseases involving ZEB1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset. | |
DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with ZEB1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with ZEB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZEB1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
DisGeNET Gene-Disease Associations | diseases associated with ZEB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
DisGeNET Gene-Phenotype Associations | phenotypes associated with ZEB1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZEB1 gene from the ENCODE Histone Modification Site Profiles dataset. | |
ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZEB1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZEB1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing ZEB1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
GAD Gene-Disease Associations | diseases associated with ZEB1 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
GeneRIF Biological Term Annotations | biological terms co-occuring with ZEB1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZEB1 from the GeneSigDB Published Gene Signatures dataset. | |
GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZEB1 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
GO Biological Process Annotations 2015 | biological processes involving ZEB1 gene from the curated GO Biological Process Annotations 2015 dataset. | |
GO Biological Process Annotations 2023 | biological processes involving ZEB1 gene from the curated GO Biological Process Annotations 2023 dataset. | |
GO Biological Process Annotations 2025 | biological processes involving ZEB1 gene from the curated GO Biological Process Annotations2025 dataset. | |
GO Cellular Component Annotations 2015 | cellular components containing ZEB1 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
GO Cellular Component Annotations 2023 | cellular components containing ZEB1 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
GO Cellular Component Annotations 2025 | cellular components containing ZEB1 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
GO Molecular Function Annotations 2015 | molecular functions performed by ZEB1 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
GO Molecular Function Annotations 2023 | molecular functions performed by ZEB1 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
GO Molecular Function Annotations 2025 | molecular functions performed by ZEB1 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
GTEx eQTL 2025 | SNPs regulating expression of ZEB1 gene from the GTEx eQTL 2025 dataset. | |
GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZEB1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZEB1 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
GWASdb SNP-Disease Associations | diseases associated with ZEB1 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
GWASdb SNP-Phenotype Associations | phenotypes associated with ZEB1 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
HMDB Metabolites of Enzymes | interacting metabolites for ZEB1 protein from the curated HMDB Metabolites of Enzymes dataset. | |
HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZEB1 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZEB1 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
HPO Gene-Disease Associations | phenotypes associated with ZEB1 gene by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset. | |
Hub Proteins Protein-Protein Interactions | interacting hub proteins for ZEB1 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
HuGE Navigator Gene-Phenotype Associations | phenotypes associated with ZEB1 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
InterPro Predicted Protein Domain Annotations | protein domains predicted for ZEB1 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZEB1 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
KEA Substrates of Kinases | kinases that phosphorylate ZEB1 protein from the curated KEA Substrates of Kinases dataset. | |
Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate ZEB1 protein from the Kinase Library Serine Threonine Atlas dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZEB1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZEB1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with ZEB1 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZEB1 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ZEB1 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of ZEB1 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZEB1 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
LOCATE Curated Protein Localization Annotations | cellular components containing ZEB1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZEB1 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by ZEB1 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
MiRTarBase microRNA Targets | microRNAs targeting ZEB1 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ZEB1 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by ZEB1 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of ZEB1 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ZEB1 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
NURSA Protein Complexes | protein complexs containing ZEB1 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
NURSA Protein-Protein Interactions | interacting proteins for ZEB1 from the NURSA Protein-Protein Interactions dataset. | |
OMIM Gene-Disease Associations | phenotypes associated with ZEB1 gene from the curated OMIM Gene-Disease Associations dataset. | |
Pathway Commons Protein-Protein Interactions | interacting proteins for ZEB1 from the Pathway Commons Protein-Protein Interactions dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZEB1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of ZEB1 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
PFOCR Pathway Figure Associations 2023 | pathways involving ZEB1 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
PFOCR Pathway Figure Associations 2024 | pathways involving ZEB1 protein from the Wikipathways PFOCR 2024 dataset. | |
PID Pathways | pathways involving ZEB1 protein from the PID Pathways dataset. | |
Reactome Pathways 2024 | pathways involving ZEB1 protein from the Reactome Pathways 2024 dataset. | |
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZEB1 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZEB1 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZEB1 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ZEB1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZEB1 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZEB1 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZEB1 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZEB1 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ZEB1 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ZEB1 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ZEB1 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZEB1 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZEB1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZEB1 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ZEB1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZEB1 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with ZEB1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZEB1 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
WikiPathways Pathways 2014 | pathways involving ZEB1 protein from the Wikipathways Pathways 2014 dataset. | |
WikiPathways Pathways 2024 | pathways involving ZEB1 protein from the WikiPathways Pathways 2024 dataset. | |