ZFP36L1 Gene

HGNC Family	Zinc fingers
Name	ZFP36 ring finger protein-like 1
Description	This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZFP36L1 is a CCCH‐type zinc finger RNA‑binding protein that plays a central role in post‑transcriptional gene regulation by binding to AU‑rich elements (AREs) located in the 3′‑untranslated regions of many target mRNAs. By accelerating mRNA degradation, it controls the expression levels of key mediators involved in inflammation, oncogenic signaling, cell cycle progression, and differentiation. For instance, in inflammatory and osteoarthritic contexts, ZFP36L1 regulates mRNAs encoding heat shock proteins, thereby influencing chondrocyte apoptosis and joint pathology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, overexpression studies in various cancer cell types show that ZFP36L1 can suppress cell proliferation and induce G1 arrest by downregulating cyclins and other cell‑cycle factors, and it promotes monocyte/macrophage differentiation via targeting transcripts such as CDK6."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn several hematologic and solid tumor models, ZFP36L1 engages in pro‑apoptotic and differentiative processes. By promoting the decay of mRNAs encoding survival proteins such as BCL2, it facilitates apoptosis in malignant cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In hematopoiesis, its binding to STAT5b mRNA attenuates erythroid differentiation and colony formation, suggesting potential avenues for therapeutic intervention in myeloproliferative disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in keratinocytes, ZFP36L1 modulates the stability of VEGF transcripts, thereby contributing to the regulation of wound repair processes, while its altered expression has been linked to the inflammatory phenotypes observed in multiple sclerosis and psoriasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in controlling endogenous mRNA stability, ZFP36L1 functions as a critical antiviral factor by binding to viral transcripts—such as those of influenza A virus, flaviviruses (including Japanese encephalitis and dengue viruses), and human coronaviruses—and promoting their degradation via recruitment of cellular decay machineries."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": " In glioblastoma, deregulated expression of ZFP36L1, which is influenced by microRNAs such as miR‑129‑5p, correlates with poor survival, underscoring its complex role in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " Moreover, in gastric adenocarcinoma cells, ZFP36L1 participates in feedback regulation of key transcription factors by negatively controlling factors like NR4A2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and in renal cells it mediates the decay of mineralocorticoid receptor mRNA to modulate hormone‑responsive signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " Other studies have demonstrated that signaling pathways, epigenetic modifications, and microRNAs (e.g., those regulating butyrate response in osteoblasts and senescence in lung fibroblasts) impact ZFP36L1 expression and function, highlighting its multifaceted role in cell proliferation, survival, and differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "18", "end_ref": "22"}]}, {"type": "t", "text": " Recent work further extends the antiviral spectrum of ZFP36L1 to include direct destabilization of viral genomes and highlights its regulation by cellular decay complexes, thereby offering novel insights into host–virus interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": " Finally, in chronic obstructive pulmonary disease, ZFP36L1 has been implicated as a target of miR‑377‑3p in promoting fibroblast senescence and disease progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": ", while its overexpression in epithelial cells can suppress human coronavirus replication."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandhya Sanduja, Fernando F Blanco, Dan A Dixon "}, {"type": "b", "children": [{"type": "t", "text": "The roles of TTP and BRF proteins in regulated mRNA decay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Wiley Interdiscip Rev RNA (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/wrna.28"}], "href": "https://doi.org/10.1002/wrna.28"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21278925"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21278925"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Young-Ok Son, Hyo-Eun Kim, Wan-Su Choi, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jb/mvaa072"}], "href": "https://doi.org/10.1093/jb/mvaa072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32687160"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32687160"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Han Chiu, Hsin-Ping Chiu, Han-Pang Yu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-377-3p exacerbates chronic obstructive pulmonary disease through suppressing ZFP36L1 expression and inducing lung fibroblast senescence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Respir Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12931-024-02696-3"}], "href": "https://doi.org/10.1186/s12931-024-02696-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38317146"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38317146"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Tooba Momin, Andrew Villasenor, Amit Singh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZFP36 ring finger protein like 1 significantly suppresses human coronavirus OC43 replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PeerJ (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7717/peerj.14776"}], "href": "https://doi.org/10.7717/peerj.14776"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36846448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36846448"}]}]}]}
Synonyms	BERG36, BRF1, ERF-1, TIS11B, cMG1, RNF162B, ERF1
Proteins	TISB_HUMAN
NCBI Gene ID	677
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZFP36L1 has 15,247 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 136 datasets.

Click the + buttons to view associations for ZFP36L1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZFP36L1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by ZFP36L1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFP36L1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFP36L1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZFP36L1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZFP36L1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZFP36L1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFP36L1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZFP36L1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZFP36L1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZFP36L1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZFP36L1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZFP36L1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZFP36L1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ZFP36L1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ZFP36L1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFP36L1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZFP36L1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZFP36L1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of ZFP36L1 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZFP36L1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZFP36L1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ZFP36L1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZFP36L1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZFP36L1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZFP36L1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZFP36L1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ZFP36L1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ZFP36L1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ZFP36L1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ZFP36L1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ZFP36L1 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ZFP36L1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ZFP36L1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZFP36L1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZFP36L1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZFP36L1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ZFP36L1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZFP36L1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFP36L1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZFP36L1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.