ZFYVE26 Gene

HGNC Family	Zinc fingers
Name	zinc finger, FYVE domain containing 26
Description	This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZFYVE26—also known as spastizin or FYVE‐CENT—is a multifunctional protein whose activity centers on the regulation of membrane trafficking during cell division. Its FYVE domain binds phosphatidylinositol 3‑phosphate (PI3P), enabling its localization to the midbody during cytokinesis where it is recruited by the PI(3)K‑III complex. At the midbody, ZFYVE26 forms part of a machinery that includes binding partners such as TTC19, the microtubule motor KIF13A, and components of the ESCRT‑III complex, thereby promoting abscission and ensuring faithful cell division. In addition, ZFYVE26 interacts with elements of a coat‐like complex (including components of the AP‑5 complex and SPG11/spatacsin) and shows partial colocalization with early endosomes and the endoplasmic reticulum, suggesting a broader role in intracellular protein sorting and membrane dynamics."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n\nZFYVE26 plays a pivotal role in maintaining cellular homeostasis through its regulation of autophagy and lysosomal biogenesis. The protein is critical for autophagic lysosome reformation (ALR) by facilitating the maturation of autophagosomes and promoting their fusion with endosomes and lysosomes—a process that depends on its direct binding to PI3P via its FYVE domain. In this way, ZFYVE26 associates with the Beclin 1–UVRAG–Rubicon complex and modulates the activity of key endocytic regulators such as RAB5A and RAB11, ensuring proper membrane flow and clearance of autophagic substrates. Supporting these molecular observations, loss of ZFYVE26 function in cells (and neuronal models) leads to the accumulation of immature autophagosomes, defects in organellar recycling, and even secondary mitochondrial abnormalities that compromise axonal integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n\nMutations in ZFYVE26 underlie SPG15, an autosomal recessive form of hereditary spastic paraplegia characterized by early developmental delays, progressive spastic paraparesis, cognitive impairment, thinning of the corpus callosum, and other neurological deficits. Genetic mapping and clinical studies in diverse populations have documented a wide spectrum of truncating mutations that abrogate ZFYVE26 function, linking disruption of both cytokinesis and autophagic clearance to neurodegeneration. Patient‐derived cells and animal models further reveal that loss of spastizin impairs intracellular trafficking and autophagosome maturation, thereby contributing to axonal degeneration and the complex phenotype of SPG15. These findings highlight ZFYVE26 as a key mediator of membrane dynamics at the crossroad of cell division, endocytosis, and autophagy, and underscore its importance in neuronal survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Antonia P Sagona, Ioannis P Nezis, Nina Marie Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb2036"}], "href": "https://doi.org/10.1038/ncb2036"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20208530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20208530"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jennifer Hirst, Georg H H Borner, James Edgar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E13-03-0170"}], "href": "https://doi.org/10.1091/mbc.E13-03-0170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23825025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23825025"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chiara Vantaggiato, Claudia Crimella, Giovanni Airoldi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awt227"}], "href": "https://doi.org/10.1093/brain/awt227"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24030950"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24030950"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Reena Prity Murmu, Elodie Martin, Agnès Rastetter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mcn.2011.04.004"}], "href": "https://doi.org/10.1016/j.mcn.2011.04.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21545838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21545838"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Antonia P Sagona, Ioannis P Nezis, Kristi G Bache, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0017086"}], "href": "https://doi.org/10.1371/journal.pone.0017086"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21455500"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21455500"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jaerak Chang, Seongju Lee, Craig Blackstone "}, {"type": "b", "children": [{"type": "t", "text": "Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI77598"}], "href": "https://doi.org/10.1172/JCI77598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25365221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25365221"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chiara Vantaggiato, Elena Panzeri, Marianna Castelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZFYVE26/SPASTIZIN and SPG11/SPATACSIN mutations in hereditary spastic paraplegia types AR-SPG15 and AR-SPG11 have different effects on autophagy and endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2018.1507438"}], "href": "https://doi.org/10.1080/15548627.2018.1507438"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30081747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30081747"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Chiara Vantaggiato, Emilio Clementi, Maria Teresa Bassi "}, {"type": "b", "children": [{"type": "t", "text": "ZFYVE26/SPASTIZIN: a close link between complicated hereditary spastic paraparesis and autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/auto.27173"}], "href": "https://doi.org/10.4161/auto.27173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24284334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24284334"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Kyle Denton, Yongchao Mou, Chong-Chong Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddy156"}], "href": "https://doi.org/10.1093/hmg/ddy156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29726929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29726929"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Afshin Saffari, Melanie Kellner, Catherine Jordan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The clinical and molecular spectrum of ZFYVE26-associated hereditary spastic paraplegia: SPG15."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brain (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/brain/awac391"}], "href": "https://doi.org/10.1093/brain/awac391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36315648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36315648"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Sylvain Hanein, Elodie Martin, Amir Boukhris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2008.03.004"}], "href": "https://doi.org/10.1016/j.ajhg.2008.03.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18394578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18394578"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "C Goizet, A Boukhris, D Maltete, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurology (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1212/WNL.0b013e3181bacf59"}], "href": "https://doi.org/10.1212/WNL.0b013e3181bacf59"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19805727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19805727"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "R Schüle, N Schlipf, M Synofzik, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Neurosurg Psychiatry (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jnnp.2008.167528"}], "href": "https://doi.org/10.1136/jnnp.2008.167528"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19917823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19917823"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Amir Boukhris, Giovanni Stevanin, Imed Feki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hereditary spastic paraplegia with mental impairment and thin corpus callosum in Tunisia: SPG11, SPG15, and further genetic heterogeneity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Neurol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archneur.65.3.393"}], "href": "https://doi.org/10.1001/archneur.65.3.393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18332254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18332254"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Daliya Kancheva, Derek Atkinson, Peter De Rijk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel mutations in genes causing hereditary spastic paraplegia and Charcot-Marie-Tooth neuropathy identified by an optimized protocol for homozygosity mapping based on whole-exome sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gim.2015.139"}], "href": "https://doi.org/10.1038/gim.2015.139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26492578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26492578"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Nizar Elleuch, Naima Bouslam, Sylvain Hanein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Refinement of the SPG15 candidate interval and phenotypic heterogeneity in three large Arab families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurogenetics (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10048-007-0097-x"}], "href": "https://doi.org/10.1007/s10048-007-0097-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17661097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17661097"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Farah Bibi, Stephanie Efthymiou, Thomas Bourinaris, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare novel CYP2U1 and ZFYVE26 variants identified in two Pakistani families with spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jns.2020.116669"}], "href": "https://doi.org/10.1016/j.jns.2020.116669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32006740"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32006740"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Mahdieh Pashaei, Atefeh Davarzani, Reza Hajati, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Description of clinical features and genetic analysis of one ultra-rare (SPG64) and two common forms (SPG5A and SPG15) of hereditary spastic paraplegia families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurogenet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/01677063.2021.1895146"}], "href": "https://doi.org/10.1080/01677063.2021.1895146"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33771085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33771085"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Shao-Lun Hsu, Yi-Jiun Lu, Yu-Shuen Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Investigating ZFYVE26 mutations in a Taiwanese cohort with hereditary spastic paraplegia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Formos Med Assoc (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jfma.2021.02.005"}], "href": "https://doi.org/10.1016/j.jfma.2021.02.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33637369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33637369"}]}]}]}
Synonyms	SPG15, FYVE-CENT
Proteins	ZFY26_HUMAN
NCBI Gene ID	23503
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZFYVE26 has 6,267 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 119 datasets.

Click the + buttons to view associations for ZFYVE26 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZFYVE26 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFYVE26 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFYVE26 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZFYVE26 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZFYVE26 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZFYVE26 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZFYVE26 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZFYVE26 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZFYVE26 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZFYVE26 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZFYVE26 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZFYVE26 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZFYVE26 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ZFYVE26 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ZFYVE26 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFYVE26 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZFYVE26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZFYVE26 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with ZFYVE26 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with ZFYVE26 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZFYVE26 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZFYVE26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ZFYVE26 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZFYVE26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZFYVE26 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZFYVE26 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZFYVE26 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ZFYVE26 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ZFYVE26 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ZFYVE26 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ZFYVE26 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving ZFYVE26 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving ZFYVE26 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZFYVE26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZFYVE26 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZFYVE26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ZFYVE26 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZFYVE26 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFYVE26 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZFYVE26 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ZFYVE26 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.