ZFYVE9 Gene

HGNC Family Zinc fingers
Name zinc finger, FYVE domain containing 9
Description This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZFYVE9, also known as Smad Anchor for Receptor Activation (SARA), is a FYVE domain‐containing adaptor protein that primarily localizes to early endosomes by binding phosphatidylinositol 3‐phosphate. Its intrinsically flexible, largely disordered Smad‐binding domain enables it to recruit non‑phosphorylated Smad2/3 to activated TGF‑β receptors, thereby facilitating their phosphorylation and proper downstream signal transduction. In addition, related FYVE proteins—such as endofin, which preferentially modulates BMP–Smad signaling—underscore the versatility and context‐dependent functions of this protein family. Intriguingly, beyond its canonical role in TGF‑β signaling, ZFYVE9 has been implicated in specialized membrane trafficking events, such as orchestrating vesicular delivery during photoreceptor outer segment disc formation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nLocalizing to endosomes not only positions ZFYVE9 for Smad recruitment but also integrates it into the regulation of receptor trafficking and signal modulation. For example, its interactions with endocytic regulators—including PI3K subunits and the small GTPase Rab5—are critical for the internalization of TGF‑β receptors and formation of productive SARA–Smad complexes. Alterations in ZFYVE9 expression, whether through proteasome‐dependent degradation mediated by Smurf2/Smad7 complexes or via PI3K pathway perturbation, have been linked to impaired Smad2 activation. These changes are especially consequential in cellular models where high glucose or similar stressors provoke epithelial–mesenchymal transition (EMT) and extracellular matrix reorganization. Furthermore, binding partners such as ERBIN have been shown to interact with ZFYVE9, shifting the balance of Smad-dependent transcription and fine-tuning cellular responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its central roles in receptor trafficking and Smad activation, ZFYVE9 is implicated in diverse physiological and pathological contexts. In the retina, it contributes to the precise vesicular targeting of rhodopsin required for outer segment disc biogenesis, whereas in the central nervous system elevated ZFYVE9 expression and consequent Smad3 activation have been associated with temporal lobe epilepsy. Moreover, structural studies reveal that its disordered Smad-binding region mediates interactions via hydrophobic patches on the MH2 domains of Smads, providing a flexible mechanism for recognition of diverse targets. Notably, conflicting findings in certain B-cell lymphomas have suggested that ZFYVE9 may be dispensable for TGF‑β signaling under specific conditions. Finally, it is important to recognize that the acronym “SARA” is also used to denote the Scale for Assessment and Rating of Ataxia—a clinical instrument entirely distinct from the ZFYVE9 adaptor protein."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Ekaterini Panopoulou, David J Gillooly, Jeffrey L Wrana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early endosomal regulation of Smad-dependent signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M107983200"}], "href": "https://doi.org/10.1074/jbc.M107983200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11877415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11877415"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yang Hu, Jen-Zen Chuang, Kai Xu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M404375200"}], "href": "https://doi.org/10.1074/jbc.M404375200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15231848"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15231848"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Constance E Runyan, H William Schnaper, Anne-Christine Poncelet "}, {"type": "b", "children": [{"type": "t", "text": "The role of internalization in transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M407939200"}], "href": "https://doi.org/10.1074/jbc.M407939200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15613484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15613484"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Weibin Shi, Chenbei Chang, Shuyi Nie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endofin acts as a Smad anchor for receptor activation in BMP signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.03400"}], "href": "https://doi.org/10.1242/jcs.03400"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17356069"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17356069"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jen-Zen Chuang, Yu Zhao, Ching-Hwa Sung "}, {"type": "b", "children": [{"type": "t", "text": "SARA-regulated vesicular targeting underlies formation of the light-sensing organelle in mammalian rods."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2007.06.030"}], "href": "https://doi.org/10.1016/j.cell.2007.06.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17693260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17693260"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Constance E Runyan, Tomoko Hayashida, Susan Hubchak, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "[SARA expression in high glucose induced epithelium to mesenchymal transition of proximal tubule cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhong Nan Da Xue Xue Bao Yi Xue Ban (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3969/j.issn.1672-7347.2010.12.005"}], "href": "https://doi.org/10.3969/j.issn.1672-7347.2010.12.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21200089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21200089"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "George Sflomos, Eleftherios Kostaras, Ekaterini Panopoulou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.062307"}], "href": "https://doi.org/10.1242/jcs.062307"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21878490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21878490"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Maren Bakkebø, Kanutte Huse, Vera I Hilden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SARA is dispensable for functional TGF-β signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2012.07.027"}], "href": "https://doi.org/10.1016/j.febslet.2012.07.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22819827"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22819827"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "E Kostaras, G Sflomos, N M Pedersen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.554"}], "href": "https://doi.org/10.1038/onc.2012.554"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23222715"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23222715"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sho Aki, Kazuaki Yoshioka, Yasuo Okamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced Smad signaling in endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.601484"}], "href": "https://doi.org/10.1074/jbc.M114.601484"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25614622"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25614622"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Wen-bin Tang, Guang-hui Ling, Lin Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smad Anchor for Receptor Activation Regulates High Glucose-Induced EMT via Modulation of Smad2 and Smad3 Activities in Renal Tubular Epithelial Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephron (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000431105"}], "href": "https://doi.org/10.1159/000431105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26159183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26159183"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stephanie Wojtowicz, Sanghyun Lee, Eddie Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SMURF2 and SMAD7 induce SARA degradation via the proteasome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2020.109627"}], "href": "https://doi.org/10.1016/j.cellsig.2020.109627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32283253"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32283253"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Justin B Goh, Daniel F Wallace, Wanjin Hong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endofin, a novel BMP-SMAD regulator of the iron-regulatory hormone, hepcidin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep13986"}], "href": "https://doi.org/10.1038/srep13986"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26358513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26358513"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Wenbo Zhang, Yingshi Du, Yan Zou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Smad Anchor for Receptor Activation and Phospho-Smad3 Were Upregulated in Patients with Temporal Lobe Epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12031-019-01285-0"}], "href": "https://doi.org/10.1007/s12031-019-01285-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30847724"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30847724"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Luca Porcu, Mario Fichera, Lorenzo Nanetti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Longitudinal changes of SARA scale in Friedreich ataxia: Strong influence of baseline score and age at onset."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Clin Transl Neurol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/acn3.51886"}], "href": "https://doi.org/10.1002/acn3.51886"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37641437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37641437"}]}]}]}
Synonyms SARA, PPP1R173, SMADIP, MADHIP
Proteins ZFYV9_HUMAN
NCBI Gene ID 9372
API
Download Associations
Predicted Functions View ZFYVE9's ARCHS4 Predicted Functions.
Co-expressed Genes View ZFYVE9's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View ZFYVE9's ARCHS4 Predicted Functions.

Functional Associations

ZFYVE9 has 5,538 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 111 datasets.

Click the + buttons to view associations for ZFYVE9 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
Achilles Cell Line Gene Essentiality Profiles cell lines with fitness changed by ZFYVE9 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ZFYVE9 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles tissues with high or low expression of ZFYVE9 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles tissues with high or low expression of ZFYVE9 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
BioGPS Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
BioGPS Human Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ZFYVE9 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
BioGPS Mouse Cell Type and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ZFYVE9 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of ZFYVE9 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
CCLE Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
CCLE Cell Line Gene Mutation Profiles cell lines with ZFYVE9 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
CCLE Cell Line Proteomics Cell lines associated with ZFYVE9 protein from the CCLE Cell Line Proteomics dataset.
ChEA Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFYVE9 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
ChEA Transcription Factor Targets transcription factors binding the promoter of ZFYVE9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
ChEA Transcription Factor Targets 2022 transcription factors binding the promoter of ZFYVE9 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
CMAP Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of ZFYVE9 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores cellular components containing ZFYVE9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
COMPARTMENTS Curated Protein Localization Evidence Scores 2025 cellular components containing ZFYVE9 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores cellular components co-occuring with ZFYVE9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 cellular components co-occuring with ZFYVE9 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
CORUM Protein Complexes protein complexs containing ZFYVE9 protein from the CORUM Protein Complexes dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of ZFYVE9 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene Mutation Profiles cell lines with ZFYVE9 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
CTD Gene-Disease Associations diseases associated with ZFYVE9 gene/protein from the curated CTD Gene-Disease Associations dataset.
dbGAP Gene-Trait Associations traits associated with ZFYVE9 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
DeepCoverMOA Drug Mechanisms of Action small molecule perturbations with high or low expression of ZFYVE9 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
DepMap CRISPR Gene Dependency cell lines with fitness changed by ZFYVE9 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores diseases co-occuring with ZFYVE9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 diseases co-occuring with ZFYVE9 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
DisGeNET Gene-Disease Associations diseases associated with ZFYVE9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
DisGeNET Gene-Phenotype Associations phenotypes associated with ZFYVE9 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
ENCODE Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ZFYVE9 gene from the ENCODE Histone Modification Site Profiles dataset.
ENCODE Transcription Factor Binding Site Profiles transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZFYVE9 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
ENCODE Transcription Factor Targets transcription factors binding the promoter of ZFYVE9 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
ESCAPE Omics Signatures of Genes and Proteins for Stem Cells PubMedIDs of publications reporting gene signatures containing ZFYVE9 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
GAD Gene-Disease Associations diseases associated with ZFYVE9 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
GDSC Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with ZFYVE9 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing ZFYVE9 from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of ZFYVE9 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GO Biological Process Annotations 2015 biological processes involving ZFYVE9 gene from the curated GO Biological Process Annotations 2015 dataset.
GO Biological Process Annotations 2023 biological processes involving ZFYVE9 gene from the curated GO Biological Process Annotations 2023 dataset.
GO Biological Process Annotations 2025 biological processes involving ZFYVE9 gene from the curated GO Biological Process Annotations2025 dataset.
GO Cellular Component Annotations 2015 cellular components containing ZFYVE9 protein from the curated GO Cellular Component Annotations 2015 dataset.
GO Cellular Component Annotations 2023 cellular components containing ZFYVE9 protein from the curated GO Cellular Component Annotations 2023 dataset.
GO Cellular Component Annotations 2025 cellular components containing ZFYVE9 protein from the curated GO Cellular Component Annotations 2025 dataset.
GO Molecular Function Annotations 2015 molecular functions performed by ZFYVE9 gene from the curated GO Molecular Function Annotations 2015 dataset.
GO Molecular Function Annotations 2023 molecular functions performed by ZFYVE9 gene from the curated GO Molecular Function Annotations 2023 dataset.
GO Molecular Function Annotations 2025 molecular functions performed by ZFYVE9 gene from the curated GO Molecular Function Annotations 2025 dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of ZFYVE9 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Gene Expression Profiles 2023 tissues with high or low expression of ZFYVE9 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
GTEx Tissue-Specific Aging Signatures tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset.
GWASdb SNP-Disease Associations diseases associated with ZFYVE9 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.
GWASdb SNP-Phenotype Associations phenotypes associated with ZFYVE9 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.
Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset.
HPA Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
HPA Tissue Gene Expression Profiles tissues with high or low expression of ZFYVE9 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset.
HPA Tissue Protein Expression Profiles tissues with high or low expression of ZFYVE9 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset.
HPA Tissue Sample Gene Expression Profiles tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset.
Hub Proteins Protein-Protein Interactions interacting hub proteins for ZFYVE9 from the curated Hub Proteins Protein-Protein Interactions dataset.
InterPro Predicted Protein Domain Annotations protein domains predicted for ZFYVE9 protein from the InterPro Predicted Protein Domain Annotations dataset.
JASPAR Predicted Transcription Factor Targets transcription factors regulating expression of ZFYVE9 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
KEGG Pathways pathways involving ZFYVE9 protein from the KEGG Pathways dataset.
Kinase Library Serine Threonine Kinome Atlas kinases that phosphorylate ZFYVE9 protein from the Kinase Library Serine Threonine Atlas dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of ZFYVE9 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of ZFYVE9 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles cell lines with ZFYVE9 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset.
KnockTF Gene Expression Profiles with Transcription Factor Perturbations transcription factor perturbations changing expression of ZFYVE9 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
LINCS L1000 CMAP Chemical Perturbation Consensus Signatures small molecule perturbations changing expression of ZFYVE9 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset.
LINCS L1000 CMAP CRISPR Knockout Consensus Signatures gene perturbations changing expression of ZFYVE9 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
LOCATE Curated Protein Localization Annotations cellular components containing ZFYVE9 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain ZFYVE9 protein from the LOCATE Predicted Protein Localization Annotations dataset.
MiRTarBase microRNA Targets microRNAs targeting ZFYVE9 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of ZFYVE9 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles drug perturbations changing expression of ZFYVE9 gene from the NIBR DRUG-seq U2OS MoA Box dataset.
NURSA Protein Complexes protein complexs containing ZFYVE9 protein recovered by IP-MS from the NURSA Protein Complexes dataset.
PANTHER Pathways pathways involving ZFYVE9 protein from the PANTHER Pathways dataset.
Pathway Commons Protein-Protein Interactions interacting proteins for ZFYVE9 from the Pathway Commons Protein-Protein Interactions dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of ZFYVE9 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations gene perturbations changing expression of ZFYVE9 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
PFOCR Pathway Figure Associations 2023 pathways involving ZFYVE9 protein from the PFOCR Pathway Figure Associations 2023 dataset.
PFOCR Pathway Figure Associations 2024 pathways involving ZFYVE9 protein from the Wikipathways PFOCR 2024 dataset.
PID Pathways pathways involving ZFYVE9 protein from the PID Pathways dataset.
Reactome Pathways 2014 pathways involving ZFYVE9 protein from the Reactome Pathways dataset.
Reactome Pathways 2024 pathways involving ZFYVE9 protein from the Reactome Pathways 2024 dataset.
Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ZFYVE9 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ZFYVE9 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset.
Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures gene perturbations changing expression of ZFYVE9 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of ZFYVE9 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.
Roadmap Epigenomics Cell and Tissue Gene Expression Profiles cell types and tissues with high or low expression of ZFYVE9 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset.
Roadmap Epigenomics Histone Modification Site Profiles histone modification site profiles with high histone modification abundance at ZFYVE9 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset.
RummaGEO Drug Perturbation Signatures drug perturbations changing expression of ZFYVE9 gene from the RummaGEO Drug Perturbation Signatures dataset.
RummaGEO Gene Perturbation Signatures gene perturbations changing expression of ZFYVE9 gene from the RummaGEO Gene Perturbation Signatures dataset.
TargetScan Predicted Conserved microRNA Targets microRNAs regulating expression of ZFYVE9 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset.
TargetScan Predicted Nonconserved microRNA Targets microRNAs regulating expression of ZFYVE9 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
TCGA Signatures of Differentially Expressed Genes for Tumors tissue samples with high or low expression of ZFYVE9 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores tissues with high expression of ZFYVE9 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
TISSUES Curated Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ZFYVE9 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores tissues with high expression of ZFYVE9 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.
TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 tissues with high expression of ZFYVE9 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores tissues co-occuring with ZFYVE9 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.
TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 tissues co-occuring with ZFYVE9 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.
WikiPathways Pathways 2014 pathways involving ZFYVE9 protein from the Wikipathways Pathways 2014 dataset.
WikiPathways Pathways 2024 pathways involving ZFYVE9 protein from the WikiPathways Pathways 2024 dataset.