{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZIC3 is a zinc‐finger transcription factor that plays a central role in early embryogenesis by regulating left–right axis formation and cardiac morphogenesis. Mutations in ZIC3 have been repeatedly linked to heterotaxy and a spectrum of congenital heart defects, with aberrant subcellular trafficking and loss of normal nuclear localization being prominent features. In affected patients, both missense and truncating mutations disrupt key zinc‐finger and N‐terminal domains, leading to diminished or lost transactivation activity and consequent malformations such as situs ambiguus, dextrocardia, and other laterality defects. Such studies, including investigations in familial cases and sporadic cohorts, indicate that although ZIC3 mutations account for only a small percentage of affected individuals, the consequences are clinically significant."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "13"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, ZIC3 functions as a transcriptional regulator whose activity depends on precise nuclear import and post‐translational modifications. Detailed mechanistic studies have highlighted that ZIC3 contains a bipartite nuclear localization signal within its zinc finger domains and is subject to sumoylation, a modification that enhances its nuclear retention and repressive function on key target gene promoters involved in cardiac development. Moreover, physical and functional interactions with other transcription factors such as GLI3 and serum response factor (SRF) help integrate signaling pathways during heart and neural development, underscoring the importance of its regulated nucleocytoplasmic shuttling."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its well‐established role in laterality and heart formation, ZIC3 has additional functions in several developmental and pathological contexts. In the organizer region, cis‐regulatory enhancer studies have demonstrated that elements controlling ZIC3 expression are critical for meso‐ectodermal specification. In the retina, ZIC3 is expressed in a gradient that is essential for proper retinal ganglion axon targeting, while in other models, perturbation of ZIC3 impacts ventral body wall formation and vascular smooth muscle cell viability. Furthermore, emerging data suggest that dysregulation of ZIC3 contributes not only to congenital malformations seen in disorders such as OAVS/VACTERL associations but also to processes relevant to tumor suppression and stem cell pluripotency through enhancer activation and cooperation with chromatin remodeling complexes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "28"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stephanie M Ware, Jianlan Peng, Lirong Zhu, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Situs ambiguus in a female fetus with balanced (X;21) translocation--evidence for functional nullisomy of the ZIC3 gene?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.ejhg.5201213"}], "href": "https://doi.org/10.1038/sj.ejhg.5201213"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15470371"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15470371"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "James E J Bedard, Jennifer D Purnell, Stephanie M Ware "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddl461"}], "href": "https://doi.org/10.1093/hmg/ddl461"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17185387"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17185387"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Brigitte Chhin, Minoru Hatayama, Dominique Bozon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elucidation of penetrance variability of a ZIC3 mutation in a family with complex heart defects and functional analysis of ZIC3 mutations in the first zinc finger domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20480"}], "href": "https://doi.org/10.1002/humu.20480"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17295247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17295247"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Minoru Hatayama, Tadashi Tomizawa, Kumiko Sakai-Kato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddn239"}], "href": "https://doi.org/10.1093/hmg/ddn239"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18716025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18716025"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "James E J Bedard, Allison M Haaning, Stephanie M Ware "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel ZIC3 isoform and mutation screening in patients with heterotaxy and congenital heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0023755"}], "href": "https://doi.org/10.1371/journal.pone.0023755"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21858219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21858219"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lijiang Ma, Elif Seda Selamet Tierney, Teresa Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in ZIC3 and ACVR2B are a common cause of heterotaxy and associated cardiovascular anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiol Young (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1017/S1047951111001181"}], "href": "https://doi.org/10.1017/S1047951111001181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21864452"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21864452"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Lisa C A D'Alessandro, Brett Casey, Victoria Mok Siu "}, {"type": "b", "children": [{"type": "t", "text": "Situs inversus totalis and a novel ZIC3 mutation in a family with X-linked heterotaxy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Congenit Heart Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1747-0803.2011.00602.x"}], "href": "https://doi.org/10.1111/j.1747-0803.2011.00602.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22171628"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22171628"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lisa C A D'Alessandro, Brande C Latney, Prasuna C Paluru, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The phenotypic spectrum of ZIC3 mutations includes isolated d-transposition of the great arteries and double outlet right ventricle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.35849"}], "href": "https://doi.org/10.1002/ajmg.a.35849"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23427188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23427188"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jason Cowan, Muhammad Tariq, Stephanie M Ware "}, {"type": "b", "children": [{"type": "t", "text": "Genetic and functional analyses of ZIC3 variants in congenital heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22457"}], "href": "https://doi.org/10.1002/humu.22457"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24123890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24123890"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Alina C Hilger, Jan Halbritter, Tracie Pennimpede, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted Resequencing of 29 Candidate Genes and Mouse Expression Studies Implicate ZIC3 and FOXF1 in Human VATER/VACTERL Association."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.22859"}], "href": "https://doi.org/10.1002/humu.22859"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26294094"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26294094"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Aimee D C Paulussen, Anja Steyls, Jo Vanoevelen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rare novel variants in the ZIC3 gene cause X-linked heterotaxy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2016.91"}], "href": "https://doi.org/10.1038/ejhg.2016.91"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27406248"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27406248"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yu Wang, Xiaohui Dai, Hanmin Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ZIC3 mutation in a Chinese family with heterotaxy and multiple types of congenital heart defect."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Prenat Diagn (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pd.6294"}], "href": "https://doi.org/10.1002/pd.6294"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36567274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36567274"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Lirong Zhu, Karine G Harutyunyan, Jian Lan Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a novel role of ZIC3 in regulating cardiac development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddm106"}], "href": "https://doi.org/10.1093/hmg/ddm106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17468179"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17468179"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Lirong Zhu, Guisheng Zhou, Suzanne Poole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the interactions of human ZIC3 mutants with GLI3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mutat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/humu.20606"}], "href": "https://doi.org/10.1002/humu.20606"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17764085"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17764085"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Li Chen, Yanlin Ma, Ling Qian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sumoylation regulates nuclear localization and function of zinc finger transcription factor ZIC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2013.07.009"}], "href": "https://doi.org/10.1016/j.bbamcr.2013.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23872418"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23872418"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Helen M Bellchambers, Stephanie M Ware "}, {"type": "b", "children": [{"type": "t", "text": "ZIC3 in Heterotaxy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Exp Med Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/978-981-10-7311-3_15"}], "href": "https://doi.org/10.1007/978-981-10-7311-3_15"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29442328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29442328"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Shuolin Li, Sida Liu, Weicheng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-30204-3"}], "href": "https://doi.org/10.1038/s41598-018-30204-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30120289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30120289"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Joseph R Weber, Sergei Y Sokol "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a phylogenetically conserved activin-responsive enhancer in the Zic3 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mech Dev (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0925-4773(03)00082-0"}], "href": "https://doi.org/10.1016/s0925-4773(03"}, {"type": "t", "text": "00082-0) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12963115"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12963115"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Riko Klootwijk, Pascal Groenen, Mascha Schijvenaars, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.20402"}], "href": "https://doi.org/10.1002/ajmg.a.20402"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14679585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14679585"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jinhua Zhang, Zhe Jin, Zheng-Zheng Bao "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of gradient expression of Zic3 resulted in abnormal intra-retinal axon projection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.01041"}], "href": "https://doi.org/10.1242/dev.01041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14985256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14985256"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Takashi Doi, Prem Puri, John Bannigan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of GLI3-ZIC3 interaction in the cadmium-induced omphalocele chick model."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pediatr Surg Int (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00383-010-2779-y"}], "href": "https://doi.org/10.1007/s00383-010-2779-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21069353"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21069353"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Bin Yang, Lin Jia, Qiaojuan Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-564 functions as a tumor suppressor in human lung cancer by targeting ZIC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.10.082"}], "href": "https://doi.org/10.1016/j.bbrc.2015.10.082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26498524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26498524"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Yuri S Odaka, Takahide Tohmonda, Atsushi Toyoda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-33235-y"}], "href": "https://doi.org/10.1038/s41598-018-33235-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30297839"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30297839"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lei Zhao, Yang Ouyang, Yang Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-155-5p inhibits the viability of vascular smooth muscle cell via targeting FOS and ZIC3 to promote aneurysm formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Pharmacol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejphar.2019.03.030"}], "href": "https://doi.org/10.1016/j.ejphar.2019.03.030"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30898623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30898623"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Aurélien Trimouille, Angèle Tingaud-Sequeira, Didier Lacombe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Description of a family with X-linked oculo-auriculo-vertebral spectrum associated with polyalanine tract expansion in ZIC3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13811"}], "href": "https://doi.org/10.1111/cge.13811"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32639022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32639022"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Jianya Gao, Lei Liu, Zecheng Wu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zic family member 3 attenuates oxidative stress-induced vascular smooth muscle cell apoptosis in patients with chronic kidney disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tissue Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.tice.2023.102286"}], "href": "https://doi.org/10.1016/j.tice.2023.102286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38091851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38091851"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Ishtiaque Hossain, Pierre Priam, Sofia C Reynoso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-52431-1"}], "href": "https://doi.org/10.1038/s41467-024-52431-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39358345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39358345"}]}]}]}