{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZNF217 is a Kruppel‐like zinc finger protein frequently amplified on chromosome 20q13 that acts as a potent modulator of gene expression. It functions both as a transcriptional repressor and as an epigenetic regulator by assembling multi‐protein complexes with co‐repressors such as CtBP, LSD1, CoREST and histone deacetylases. Structural studies reveal that ZNF217 binds specific DNA targets—including promoters of tumor‐suppressive genes like E‑cadherin and p15INK4b—via noncanonical zinc finger interactions, thereby rewiring the transcriptional landscape to favor cell survival and dedifferentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its core role in chromatin modification, ZNF217 drives aggressive tumor behavior by promoting epithelial‐to‐mesenchymal transition (EMT), enhancing cancer stem cell characteristics, and fostering metastatic potential. In breast cancer models, for instance, ZNF217 contributes to hypoxia‐induced pluripotency by interfering with m⁶A RNA methylation of key transcripts, and it cooperates with TGF‑β signaling to mediate resistance to targeted therapies such as trastuzumab. Furthermore, its overexpression has been linked to augmented Akt signaling in response to matrix stiffness, upregulated ErbB3 levels, deregulation of telomere‐associated apoptotic signals, and chromosomal amplification—all of which correlate with invasive behavior and poor clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to these direct oncogenic functions, ZNF217 expression and activity are subject to multilayered regulatory control by non‐coding RNAs—including microRNAs, long non‐coding RNAs, and circular RNAs—and by post‐transcriptional modifications. Such regulatory circuits (involving axes like miR‑200c, miR‑503, miR‑135 and competitive endogenous RNAs) have been shown to impact ZNF217 levels in a range of tumor types including ovarian clear cell carcinoma, colorectal, prostate, gastric, hepatocellular, and even certain lymphomas. Clinically, aberrantly elevated ZNF217 correlates with enhanced invasion, chemoresistance, and poor prognosis, highlighting its potential as both a prognostic biomarker and a therapeutic target across multiple malignancies."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "19", "end_ref": "35"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "J J M Cowger, Q Zhao, M Isovic, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI129249"}], "href": "https://doi.org/10.1172/JCI129249"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32721948"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32721948"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kate G R Quinlan, Alexis Verger, Paul Yaswen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amplification of zinc finger gene 217 (ZNF217) and cancer: when good fingers go bad."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbcan.2007.05.001"}], "href": "https://doi.org/10.1016/j.bbcan.2007.05.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17572303"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17572303"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Guiqing Huang, Sheryl Krig, David Kowbel, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-12-0093"}], "href": "https://doi.org/10.1158/2159-8290.CD-12-0093"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22728437"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22728437"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "S R Krig, J K Miller, S Frietze, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2010.289"}], "href": "https://doi.org/10.1038/onc.2010.289"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20661224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20661224"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Aurélie Bellanger, Caterina F Donini, Julie A Vendrell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The critical role of the ZNF217 oncogene in promoting breast cancer metastasis to the bone."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4882"}], "href": "https://doi.org/10.1002/path.4882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28207159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28207159"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Masayuki Shimada, Johji Imura, Takazumi Kozaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15756435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15756435"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wenzhe Si, Yang Zhao, Jiansuo Zhou, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Interferon regulatory factor 5‑induced upregulation of zinc‑finger protein 217 promotes pancreatic carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2022.12705"}], "href": "https://doi.org/10.3892/mmr.2022.12705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35362545"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35362545"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hsien-Neng Huang, Ming-Chieh Lin, Wen-Chih Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.2013.216"}], "href": "https://doi.org/10.1038/modpathol.2013.216"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24336158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24336158"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Hua-Yu Zhu, Wen-Dong Bai, Chao Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The dark side of ZNF217, a key regulator of tumorigenesis with powerful biomarker value."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.5893"}], "href": "https://doi.org/10.18632/oncotarget.5893"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26431164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26431164"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Xing-gang Mao, Ming Yan, Xiao-yan Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lab Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/labinvest.2011.56"}], "href": "https://doi.org/10.1038/labinvest.2011.56"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21483406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21483406"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Xingkang Jiang, Yue Chen, E Du, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "ZNF217 is overexpressed and enhances cell migration and invasion in colorectal carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7314/apjcp.2015.16.6.2459"}], "href": "https://doi.org/10.7314/apjcp.2015.16.6.2459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25824781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25824781"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Mohammed Tanjimur Rahman, Kentaro Nakayama, Munmun Rahman, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Elevated expression of ZNF217 promotes prostate cancer growth by restraining ferroportin-conducted iron egress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.12753"}], "href": "https://doi.org/10.18632/oncotarget.12753"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27768596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27768596"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Jing Li, Lanlin Song, Yuwen Qiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF217 is associated with poor prognosis and enhances proliferation and metastasis in ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Clin Exp Pathol (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25031722"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25031722"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Atsuo Shida, Shuichi Fujioka, Hideaki Kurihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of ZNF217 expression in gastric carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2014)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25202062"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25202062"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Junyu Zhai, Jiansheng Liu, Xiaoyue Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "2"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " Synthesis and Inhibiting Thrombospondin-1 (TSP-1)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-03555-6"}], "href": "https://doi.org/10.1038/s41598-017-03555-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28607476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28607476"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Li-Ming Xu, Jiao Zhang, Yue Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-135 inhibits initiation of epithelial-mesenchymal transition in breast cancer by targeting ZNF217 and promoting m6A modification of NANOG."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-022-02211-2"}], "href": "https://doi.org/10.1038/s41388-022-02211-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35121826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35121826"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Huaqing Ou, Jialing Li, Qinhua Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.repbio.2022.100708"}], "href": "https://doi.org/10.1016/j.repbio.2022.100708"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36356557"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36356557"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "R Ramírez-Ramírez, M Gutiérrez-Angulo, M T Magaña, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Effect of ZNF217 gene polymorphisms on colorectal cancer development in a Mexican population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Mol Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4238/2015.January.23.9"}], "href": "https://doi.org/10.4238/2015.January.23.9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25729968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25729968"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Franziska Briest, Daniel Noerenberg, Cornelius Hennch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent ZNF217 mutations lead to transcriptional deregulation of interferon signal transduction via altered chromatin accessibility in B cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41375-023-02013-9"}], "href": "https://doi.org/10.1038/s41375-023-02013-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37648814"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37648814"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Gui-qin Sun, Mei Zhong, Yan-qing Ding, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Expression of ZNF217 in human ovarian cystadenocarcinoma and its clinical significance]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nan Fang Yi Ke Da Xue Xue Bao (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19403395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19403395"}]}]}]}