ZNF24 Gene

HGNC Family	Zinc fingers
Name	zinc finger protein 24
Description	Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZNF24 is a SCAN domain‐containing zinc finger transcription factor that functions as an important negative regulator of key oncogenic and angiogenic signals. In gastric cancer, for example, miR‑940 downregulates ZNF24, thereby enhancing cell migration, invasion, and metastasis; conversely, restoration of ZNF24 can reverse these aggressive behaviors. In addition, ZNF24 directly binds an 11‐bp fragment within the proximal promoter of VEGF, repressing its transcription, and also negatively regulates PDGFR‑β expression, highlighting its tumor‐suppressive and antiangiogenic roles."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn endothelial cells, ZNF24 is critical for modulating the angiogenic potential by regulating cell migration, invasion, and proliferation—processes linked to VEGFR2 signaling and cell cycle progression. Structural and functional analyses have revealed that the first two zinc finger motifs (ZF1–2) are necessary and sufficient for ZNF24’s nuclear localization and transcriptional activity, with mutations in key basic residues (e.g., K286, R290) impairing its ability to activate target gene promoters."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nFurther studies in colorectal cancer models demonstrate that ectopic expression of ZNF24 suppresses malignant phenotypes and drug resistance by inhibiting the Wnt pathway and activating p53 signaling. Moreover, evidence of an interaction between ZNF24 and the histone variant H2A.Z suggests a broader role in transcriptional regulation that may impact developmental processes and oncogenesis. Collectively, these findings underscore ZNF24’s multifunctional role as an inhibitor of tumor angiogenesis and progression across different contexts."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xinyang Liu, Xiaoxiao Ge, Zhe Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.4456"}], "href": "https://doi.org/10.18632/oncotarget.4456"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26317898"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26317898"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Di Jia, Sean M Hasso, Joanne Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-05-433045"}], "href": "https://doi.org/10.1182/blood-2012-05-433045"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23212515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23212515"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jianzhong Li, Xia Chen, Ying Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2010.05.110"}], "href": "https://doi.org/10.1016/j.bbrc.2010.05.110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20510677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20510677"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Di Jia, Lan Huang, Joyce Bischoff, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.14-258947"}], "href": "https://doi.org/10.1096/fj.14-258947"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25550468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25550468"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jian-Zhong Li, Xia Chen, Xue-Lian Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0079910"}], "href": "https://doi.org/10.1371/journal.pone.0079910"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24224020"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24224020"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jianzhong Li, Xia Chen, Jielu He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A yeast two-hybrid screen identifies histone H2A.Z as a transcription factor ZNF24 interactor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.24217"}], "href": "https://doi.org/10.1002/jcb.24217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22678762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22678762"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fanqi Meng, Chunlong Ai, Guoqiang Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2023.113796"}], "href": "https://doi.org/10.1016/j.yexcr.2023.113796"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37774763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37774763"}]}]}]}
Synonyms	KOX17, ZSCAN3, ZFP191, ZNF191, RSG-A
Proteins	ZNF24_HUMAN
NCBI Gene ID	7572
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZNF24 has 5,868 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 114 datasets.

Click the + buttons to view associations for ZNF24 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZNF24 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF24 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF24 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZNF24 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZNF24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZNF24 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF24 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF24 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF24 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF24 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZNF24 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF24 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF24 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with ZNF24 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ZNF24 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF24 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZNF24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZNF24 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZNF24 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZNF24 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing ZNF24 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZNF24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZNF24 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF24 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZNF24 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ZNF24 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ZNF24 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of ZNF24 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by ZNF24 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZNF24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZNF24 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZNF24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ZNF24 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZNF24 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF24 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZNF24 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ZNF24 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ZNF24 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF24 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ZNF24 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing ZNF24 from the GeneSigDB Published Gene Signatures dataset.