| HGNC Family | Zinc fingers |
| Name | zinc finger protein 358 |
| Description | Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic forelimb morphogenesis; neural tube development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nNote that none of the provided abstracts describe a role for ZNF358; rather, they consistently focus on tafazzin (TAZ), a mitochondrial transacylase essential for cardiolipin remodeling. TAZ governs the maturation of cardiolipin—a phospholipid uniquely enriched in the inner mitochondrial membrane—that is crucial for maintaining mitochondrial structure, efficient electron transport, and overall cellular bioenergetics. Disruption of TAZ function leads to aberrant cardiolipin composition, compromised cristae architecture, and elevated reactive oxygen species, which in turn contribute to the development of cardiomyopathy, skeletal myopathy, and other manifestations of Barth syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n \nDisruption of TAZ not only impairs mitochondrial bioenergetics through altered oxidative phosphorylation and electron transport chain instability but also perturbs several intracellular signaling cascades. Experimental models have revealed that TAZ deficiency interferes with mitophagosome biogenesis and activates stress–responsive pathways—including NF‑κB, mTORC2, and YAP/TAZ signaling—that are critical for cell survival, differentiation, and adaptation. Moreover, deficiencies in TAZ have been linked to defects in sarcomere assembly in cardiomyocytes, impaired germ cell differentiation, and altered proteasomal as well as immunoproteasomal activities in various cell types."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "11"}]}, {"type": "t", "text": "\n \nCollectively, the literature underscores TAZ as a pivotal regulator of mitochondrial lipid composition and function with far‐reaching consequences in multiple tissues. Beyond its established role in cardiac and skeletal muscle pathology, TAZ deficiency has been associated with defects in pancreatic islet insulin secretion, altered brain mitochondrial respiration and cognitive deficits, as well as impaired immune cell activation and fibrosis. These multifaceted roles have spurred investigations into gene replacement, targeted antioxidant therapies, and modulation of downstream signaling as potential corrective strategies for disorders such as Barth syndrome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "26"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Devrim Acehan, Zaza Khuchua, Riekelt H Houtkooper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mitochondrion (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.mito.2008.12.001"}], "href": "https://doi.org/10.1016/j.mito.2008.12.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19114128"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19114128"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Devrim Acehan, Frederic Vaz, Riekelt H Houtkooper, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.171439"}], "href": "https://doi.org/10.1074/jbc.M110.171439"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21068380"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21068380"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Gang Wang, Megan L McCain, Luhan Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.3545"}], "href": "https://doi.org/10.1038/nm.3545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24813252"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24813252"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Meghan S Soustek, Celine Baligand, Darin J Falk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Inherit Metab Dis (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10545-015-9834-8"}], "href": "https://doi.org/10.1007/s10545-015-9834-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25860817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25860817"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Paul Hsu, Xiaolei Liu, Jun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autophagy (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15548627.2015.1023984"}], "href": "https://doi.org/10.1080/15548627.2015.1023984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25919711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25919711"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Laurence C Cadalbert, Farah Naz Ghaffar, David Stevenson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0131066"}], "href": "https://doi.org/10.1371/journal.pone.0131066"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26114544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26114544"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Karol Szczepanek, Jeremy Allegood, Hema Aluri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbalip.2015.12.004"}], "href": "https://doi.org/10.1016/j.bbalip.2015.12.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26692032"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26692032"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tomohiro Kimura, Atsuko K Kimura, Mindong Ren, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Substantial Decrease in Plasmalogen in the Heart Associated with Tafazzin Deficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.8b00042"}], "href": "https://doi.org/10.1021/acs.biochem.8b00042"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29557170"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29557170"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jordan M Johnson, Patrick J Ferrara, Anthony R P Verkerke, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Cell Cardiol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yjmcc.2018.07.001"}], "href": "https://doi.org/10.1016/j.yjmcc.2018.07.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30008435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30008435"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Laura K Cole, Jin Hee Kim, Andrew A Amoscato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Mol Basis Dis (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2018.07.022"}], "href": "https://doi.org/10.1016/j.bbadis.2018.07.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30055293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30055293"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Silveli Suzuki-Hatano, Madhurima Saha, Skylar A Rizzo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AAV-Mediated TAZ Gene Replacement Restores Mitochondrial and Cardioskeletal Function in Barth Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Gene Ther (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/hum.2018.020"}], "href": "https://doi.org/10.1089/hum.2018.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30070157"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30070157"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yuan Gui, Jianzhong Li, Qingmiao Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA118.004073"}], "href": "https://doi.org/10.1074/jbc.RA118.004073"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30154246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30154246"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Arpita Chowdhury, Abhishek Aich, Gaurav Jain, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2018.09.057"}], "href": "https://doi.org/10.1016/j.celrep.2018.09.057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30332638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30332638"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Wenguang Chang, Dandan Xiao, Xiang Ao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat-Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Nutr Food Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mnfr.201801322"}], "href": "https://doi.org/10.1002/mnfr.201801322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30632304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30632304"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Catherine H Le, Lindsay G Benage, Kalyn S Specht, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.011229"}], "href": "https://doi.org/10.1074/jbc.RA119.011229"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32665401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32665401"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Toshihiro Sakurai, Zhen Chen, Arisa Yamahata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A mouse model of short-term, diet-induced fatty liver with abnormal cardiolipin remodeling via downregulated Tafazzin gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Sci Food Agric (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jsfa.11144"}], "href": "https://doi.org/10.1002/jsfa.11144"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33543498"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33543498"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Aindriu R R Maguire, Robert W E Crozier, Katie D Hunter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin Modulates Allergen-Induced Mast Cell Inflammatory Mediator Secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Immunohorizons (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/immunohorizons.2000040"}], "href": "https://doi.org/10.4049/immunohorizons.2000040"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33895725"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33895725"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Laura K Cole, Prasoon Agarwal, Christine A Doucette, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin Deficiency Reduces Basal Insulin Secretion and Mitochondrial Function in Pancreatic Islets From Male Mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrinology (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/endocr/bqab102"}], "href": "https://doi.org/10.1210/endocr/bqab102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34019639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34019639"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Hana M Zegallai, Ejlal Abu-El-Rub, Laura K Cole, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin deficiency impairs mitochondrial metabolism and function of lipopolysaccharide activated B lymphocytes in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202100811RR"}], "href": "https://doi.org/10.1096/fj.202100811RR"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34767647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34767647"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Jihee Sohn, Jelena Milosevic, Thomas Brouse, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2021005720"}], "href": "https://doi.org/10.1182/bloodadvances.2021005720"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34979560"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34979560"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Hana M Zegallai, Ejlal Abu-El-Rub, Folayemi Olayinka-Adefemi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin deficiency in mouse mesenchymal stem cells promote reprogramming of activated B lymphocytes toward immunosuppressive phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.202200145R"}], "href": "https://doi.org/10.1096/fj.202200145R"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35816277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35816277"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hana M Zegallai, Ejlal Abu-El-Rub, Edgard M Mejia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tafazzin deficiency attenuates anti-cluster of differentiation 40 and interleukin-4 activation of mouse B lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-022-03692-z"}], "href": "https://doi.org/10.1007/s00441-022-03692-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36129532"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36129532"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Wenyu Li, Pengfei Xu, Lingqi Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elabela-APJ axis mediates angiogenesis via YAP/TAZ pathway in cerebral ischemia/reperfusion injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Res (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.trsl.2023.02.002"}], "href": "https://doi.org/10.1016/j.trsl.2023.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36813109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36813109"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Brian C Leonard, Sangwan Park, Soohyun Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mice Deficient in TAZ (Wwtr1) Demonstrate Clinical Features of Late-Onset Fuchs' Endothelial Corneal Dystrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Invest Ophthalmol Vis Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1167/iovs.64.4.22"}], "href": "https://doi.org/10.1167/iovs.64.4.22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37074694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37074694"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Jiayue Hong, Julia M Kirkland, Jenica Acheta, et al. "}, {"type": "b", "children": [{"type": "t", "text": "YAP and TAZ regulate remyelination in the central nervous system."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glia (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/glia.24467"}], "href": "https://doi.org/10.1002/glia.24467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37724047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37724047"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Mahbubul H Shihan, Sachin Sharma, Carson Cable, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AMPK stimulation inhibits YAP/TAZ signaling to ameliorate hepatic fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-024-55764-5"}], "href": "https://doi.org/10.1038/s41598-024-55764-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38433278"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38433278"}]}]}]}
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| Synonyms | ZFEND |
| Proteins | ZN358_HUMAN |
| NCBI Gene ID | 140467 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF358 has 4,246 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 89 datasets.
Click the + buttons to view associations for ZNF358 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by ZNF358 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF358 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF358 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF358 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF358 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF358 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of ZNF358 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF358 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF358 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ZNF358 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF358 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI U2OS Cell Map Protein Localization Assemblies | assemblies containing ZNF358 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF358 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF358 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Experimental Protein Localization Evidence Scores | cellular components containing ZNF358 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF358 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF358 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF358 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZNF358 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF358 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF358 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF358 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZNF358 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing ZNF358 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZNF358 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZNF358 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF358 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ZNF358 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF358 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF358 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF358 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF358 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ZNF358 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF358 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF358 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ZNF358 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF358 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZNF358 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF358 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF358 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF358 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF358 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate ZNF358 protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF358 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF358 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with ZNF358 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF358 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ZNF358 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing ZNF358 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZNF358 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF358 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of ZNF358 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ZNF358 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| NURSA Protein Complexes | protein complexs containing ZNF358 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ZNF358 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF358 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of ZNF358 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving ZNF358 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ZNF358 protein from the Wikipathways PFOCR 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF358 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF358 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF358 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ZNF358 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF358 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF358 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF358 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF358 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ZNF358 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZNF358 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF358 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF358 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF358 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF358 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF358 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
