ZNF365 Gene

HGNC Family	Zinc fingers
Name	zinc finger protein 365
Description	This gene encodes a zinc finger protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast cancer susceptibility. [provided by RefSeq, Mar 2020]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nZNF365 is a multifunctional protein that plays a pivotal role in preserving genomic stability. It is rapidly induced by DNA damage signals – both by telomere dysfunction and double‐strand breaks – and is directly activated by p53 under conditions of telomere erosion. In these settings, ZNF365 suppresses the expression of common fragile sites, including telomeres, thereby preventing aberrant recombination events. Moreover, it participates in the homologous recombination repair pathway by interacting with poly(ADP‐ribose) polymerase 1 (PARP1) to tether MRE11 at the DNA end resection sites. Loss of ZNF365 function has been shown to delay mitotic progression, result in cytokinesis failure, bring about centrosomal re‐duplication, and ultimately lead to increased aneuploidy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its central role in DNA repair, ZNF365 is also implicated in cell cycle control and cellular senescence. In models of idiopathic pulmonary fibrosis, for instance, upregulation of ZNF365 in lung fibroblasts and alveolar epithelial cells appears to act in a protective manner by promoting timely cell proliferation and delaying the onset of senescence markers such as p53, p21, and γH2AX. In line with these findings, loss of ZNF365 in nasal mucosal epithelial cells hampers proliferation and compromises defense against pathogens like Staphylococcus aureus, suggesting that ZNF365 is essential for maintaining tissue integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its vital cellular functions, genetic association studies have linked variants in ZNF365 with susceptibility to several diseases including breast cancer, where its alterations may contribute to the disruption of DNA damage responses in BRCA1/2 mutation carriers. These findings, along with associations with Crohn’s disease and uric acid nephrolithiasis, underscore the clinical relevance of ZNF365. Collectively, these observations support a model in which intact ZNF365 function is essential for proper DNA repair, cell cycle progression, and maintenance of genomic integrity, while its perturbation may contribute to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yuqing Zhang, Sandra J Shin, Debra Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF365 promotes stability of fragile sites and telomeres."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Discov (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/2159-8290.CD-12-0536"}], "href": "https://doi.org/10.1158/2159-8290.CD-12-0536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23776040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23776040"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yuqing Zhang, Eunmi Park, Christopher S Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ZNF365 promotes stalled replication forks recovery to maintain genome stability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cc.25882"}], "href": "https://doi.org/10.4161/cc.25882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23966166"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23966166"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Juan Urista, Mariel Maldonado, Fernanda Toscano-Marquez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells11182848"}], "href": "https://doi.org/10.3390/cells11182848"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36139424"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36139424"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoyun Du, Longgang Yu, Lin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced Proliferative Capacity and Defense against Staphylococcus aureus in Human Nasal Mucosal Epithelium Lacking ZNF365."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Arch Allergy Immunol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000536106"}], "href": "https://doi.org/10.1159/000536106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38354721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38354721"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Fergus J Couch, Mia M Gaudet, Antonis C Antoniou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Common variants at the 19p13.1 and ZNF365 loci are associated with ER subtypes of breast cancer and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-11-0888"}], "href": "https://doi.org/10.1158/1055-9965.EPI-11-0888"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22351618"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22351618"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Seyed Reza Ghadamgahi, Leila Hosseinzadeh, Sahar Ardalan Khales, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Potential Role of Zinc Finger 365 "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "rs10822013"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "rs10995190"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Mammographic Density, Sporadic Breast Cancer Risk, and Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Iran J Med Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.30476/IJMS.2023.96141.2767"}], "href": "https://doi.org/10.30476/IJMS.2023.96141.2767"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38094285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38094285"}]}]}]}
Synonyms	SU48, UAN, ZNF365D
Proteins	TALAN_HUMAN
NCBI Gene ID	22891
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

ZNF365 has 4,951 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.

Click the + buttons to view associations for ZNF365 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

ZNF365 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF365 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF365 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of ZNF365 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of ZNF365 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of ZNF365 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of ZNF365 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF365 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF365 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of ZNF365 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of ZNF365 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF365 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF365 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with ZNF365 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF365 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of ZNF365 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of ZNF365 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of ZNF365 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing ZNF365 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing ZNF365 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with ZNF365 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with ZNF365 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of ZNF365 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with ZNF365 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with ZNF365 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with ZNF365 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with ZNF365 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with ZNF365 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with ZNF365 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with ZNF365 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with ZNF365 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with ZNF365 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with ZNF365 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at ZNF365 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF365 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of ZNF365 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing ZNF365 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with ZNF365 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with ZNF365 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of ZNF365 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with ZNF365 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.