| HGNC Family | Zinc fingers |
| Name | zinc finger protein 431 |
| Description | This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts mention ZNF431, they collectively detail the versatile functions of the secreted factor osteocrin—also known as musclin—produced mainly in skeletal muscle and bone. This molecule has emerged as an important modulator that influences metabolism, skeletal development, cardiovascular conditioning, and even renal homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn skeletal muscle, osteocrin/musclin expression is exquisitely sensitive to metabolic and hormonal cues. Its mRNA levels decrease during fasting and are restored upon re‐feeding, while insulin upregulates its expression via mechanisms that involve the suppression of FoxO1. Moreover, exposure to ER stress—such as that triggered by saturated fatty acids—induces musclin expression through PERK-dependent pathways. Additionally, exercise robustly elevates musclin production, which in turn enhances physical endurance and even contributes to improved mitochondrial biogenesis in muscle; these actions further translate into benefits for glucose metabolism and overall metabolic homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn bone, osteocrin is secreted by osteoblasts and early osteocytes where it plays a key role in regulating skeletal growth and differentiation. By binding to natriuretic peptide clearance receptors (NPR-C), osteocrin prevents the degradation of C-type natriuretic peptide, thereby enhancing cGMP signaling. This cascade stimulates chondrocyte proliferation in the growth plate, promotes osteocyte dendrite formation, and ultimately contributes to elongation of long bones—actions that are also responsive to mechanical loading and are essential for proper osteocyte maturation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOsteocrin’s influence extends beyond muscle and bone. In the heart, the myokine is essential for exercise-induced cardioprotection; loss of musclin signaling blunts cGMP-mediated mitochondrial and contractile adaptations, whereas its restoration recapitulates the benefits of physical activity. In the kidney, osteocrin ameliorates injury by augmenting GC-A signaling and thereby reducing p38 MAPK activation, which protects against podocyte damage. In addition, musclin modulates adipose tissue by binding to transferrin receptor 1 in beige adipocytes, where it dampens cAMP/PKA-dependent thermogenic programs and indirectly affects systemic metabolic regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Gethin Thomas, Pierre Moffatt, Patrick Salois, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M307310200"}], "href": "https://doi.org/10.1074/jbc.M307310200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14523025"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14523025"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hitoshi Nishizawa, Morihiro Matsuda, Yukio Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musclin, a novel skeletal muscle-derived secretory factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.C400066200"}], "href": "https://doi.org/10.1074/jbc.C400066200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15044443"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15044443"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Atsutaka Yasui, Hitoshi Nishizawa, Yosuke Okuno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.10.013"}], "href": "https://doi.org/10.1016/j.bbrc.2007.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17950246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17950246"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ning Gu, Qian Guo, Ke Mao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Palmitate increases musclin gene expression through activation of PERK signaling pathway in C2C12 myotubes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2015.10.005"}], "href": "https://doi.org/10.1016/j.bbrc.2015.10.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26449458"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26449458"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Ekaterina Subbotina, Ana Sierra, Zhiyong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Musclin is an activity-stimulated myokine that enhances physical endurance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1514250112"}], "href": "https://doi.org/10.1073/pnas.1514250112"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26668395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26668395"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Charles J Kim, Chanpreet Singh, Christine Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mustn1 ablation in skeletal muscle results in increased glucose tolerance concomitant with upregulated GLUT expression in male mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Physiol Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14814/phy2.15674"}], "href": "https://doi.org/10.14814/phy2.15674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37170065"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37170065"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xia Kang, Jin Qian, You-Xing Shi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exercise-induced Musclin determines the fate of fibro-adipogenic progenitors to control muscle homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2023.12.011"}], "href": "https://doi.org/10.1016/j.stem.2023.12.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38232727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38232727"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Pierre Moffatt, Gethin Thomas, Karine Sellin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M708596200"}], "href": "https://doi.org/10.1074/jbc.M708596200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17951249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17951249"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yugo Kanai, Akihiro Yasoda, Keita P Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI94912"}], "href": "https://doi.org/10.1172/JCI94912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28990933"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28990933"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Haruko Watanabe-Takano, Hiroki Ochi, Ayano Chiba, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanical load regulates bone growth via periosteal Osteocrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2021.109380"}], "href": "https://doi.org/10.1016/j.celrep.2021.109380"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34260913"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34260913"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jialiang S Wang, Tushar Kamath, Courtney M Mazur, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-26571-7"}], "href": "https://doi.org/10.1038/s41467-021-26571-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34725346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34725346"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yoshihiko Nishiguchi, Yusuke Hata, Ryosuke Date, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nephrol Dial Transplant (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/ndt/gfab286"}], "href": "https://doi.org/10.1093/ndt/gfab286"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34610136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34610136"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Takaya Handa, Keita P Mori, Akira Ishii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-01095-8"}], "href": "https://doi.org/10.1038/s41598-021-01095-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34750411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34750411"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Malgorzata Szaroszyk, Badder Kattih, Abel Martin-Garrido, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Skeletal muscle derived Musclin protects the heart during pathological overload."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-27634-5"}], "href": "https://doi.org/10.1038/s41467-021-27634-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35013221"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35013221"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Matthew P Harris, Shemin Zeng, Zhiyong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myokine Musclin Is Critical for Exercise-Induced Cardiac Conditioning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms24076525"}], "href": "https://doi.org/10.3390/ijms24076525"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37047496"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37047496"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Lu Jin, Shuang Han, Xue Lv, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-023-39710-z"}], "href": "https://doi.org/10.1038/s41467-023-39710-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37468484"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37468484"}]}]}]}
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| Proteins | ZN431_HUMAN |
| NCBI Gene ID | 170959 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF431 has 3,774 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 79 datasets.
Click the + buttons to view associations for ZNF431 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF431 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF431 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF431 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF431 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ZNF431 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF431 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ZNF431 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF431 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF431 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF431 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF431 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of ZNF431 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with ZNF431 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF431 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF431 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF431 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZNF431 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZNF431 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF431 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ZNF431 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF431 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZNF431 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF431 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ZNF431 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF431 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF431 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing ZNF431 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ZNF431 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF431 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF431 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ZNF431 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF431 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF431 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with ZNF431 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with ZNF431 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF431 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF431 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF431 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZNF431 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HPM Cell Type and Tissue Protein Expression Profiles | cell types and tissues with high or low expression of ZNF431 protein relative to other cell types and tissues from the HPM Cell Type and Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF431 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF431 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF431 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF431 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF431 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF431 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZNF431 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| NURSA Protein Complexes | protein complexs containing ZNF431 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ZNF431 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF431 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving ZNF431 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving ZNF431 protein from the Wikipathways PFOCR 2024 dataset. | |
| Reactome Pathways 2014 | pathways involving ZNF431 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving ZNF431 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF431 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF431 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of ZNF431 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF431 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF431 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ZNF431 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF431 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF431 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Sci-Plex Drug Perturbation Signatures | drug perturbations changing expression of ZNF431 gene from the Sci-Plex Drug Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of ZNF431 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ZNF431 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ZNF431 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZNF431 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF431 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF431 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF431 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF431 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with ZNF431 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF431 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
