| HGNC Family | Zinc fingers |
| Name | zinc finger protein 439 |
| Description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nAlthough none of the provided abstracts directly mention ZNF439, they collectively detail a broad spectrum of functions for phospholipase C (PLC) isoforms—primarily the δ1 variant—that may offer conceptual parallels for studying regulatory factors such as ZNF439. In skin, for example, loss or down‐regulation of PLCδ1 leads to progressive hair loss accompanied by abnormal keratin expression, defective hair canal formation, epidermal hyperplasia, sebaceous gland dysregulation, and even tumor development. These observations underline a key role for PLCδ1 in skin stem cell lineage commitment and in maintaining local as well as systemic immune homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn endocrine and developmental contexts, PLCδ1 contributes to sustained receptor‐mediated signaling in insulin‐secreting β‐cells by amplifying phosphoinositide hydrolysis in a Ca2+‐dependent manner, thus reinforcing hormone and neurotransmitter signals via store‐operated Ca2+ influx. Moreover, the enzyme displays cell cycle–dependent nuclear localization that correlates with a transient increase in nuclear phosphatidylinositol 4,5-bisphosphate levels—suggesting roles in proliferation and differentiation. Complementing these functions, synergistic loss of PLCδ isoforms (such as PLCδ1 and PLCδ3) in extra‐embryonic or cardiac tissues leads to trophoblast defects, placental vascular impairments, and cardiomyocyte apoptosis, underscoring their essential roles during embryogenesis and normal cardiac function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional studies expand the repertoire of PLCδ1 functions to neuronal and immunological domains. Alternative splicing and differences in pleckstrin homology–dependent lipid binding (as seen in comparisons between PLCδ1’s isoforms and related PLCδ4) highlight the capacity for differential subcellular regulation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "13"}]}, {"type": "t", "text": " In macrophages, reduced PLCδ1 expression leads to amplified IL-1β production and augmented phagocytosis, while in neurons, PLCδ1 is crucial for Ca2+-dependent activation of TRP cation channels and osmosensory transduction. Moreover, its deregulation has been implicated in conditions ranging from obesity and neurodegenerative motor neuron disease to the suppression of tumorigenic cellular behaviors in pancreatic cancer."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "14", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nCollectively, these studies underscore that PLCδ1 is a central mediator of phosphoinositide turnover and downstream Ca2+– and PKC–dependent signaling cascades in multiple tissues—including skin, endocrine, neural, and cardiovascular systems. Although ZNF439 is not directly addressed in these abstracts, understanding the multifaceted roles of PLCδ1 may provide valuable insight into how analogous regulatory proteins like ZNF439 could influence similar signaling networks.\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yoshikazu Nakamura, Kiyoko Fukami, Haiyan Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase Cdelta1 is required for skin stem cell lineage commitment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdg302"}], "href": "https://doi.org/10.1093/emboj/cdg302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12805213"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12805213"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Manabu Ichinohe, Yoshikazu Nakamura, Kentaro Sai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lack of phospholipase C-delta1 induces skin inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2007.03.082"}], "href": "https://doi.org/10.1016/j.bbrc.2007.03.082"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17397799"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17397799"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yoshikazu Nakamura, Manabu Ichinohe, Masayuki Hirata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C-delta1 is an essential molecule downstream of Foxn1, the gene responsible for the nude mutation, in normal hair development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.07-9239com"}], "href": "https://doi.org/10.1096/fj.07-9239com"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17938256"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17938256"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Fabian Runkel, Maik Hintze, Sebastian Griesing, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0039203"}], "href": "https://doi.org/10.1371/journal.pone.0039203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22723964"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22723964"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yu-Min Liu, Wei Liu, Jun-Shuang Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-018-1512-9"}], "href": "https://doi.org/10.1186/s12967-018-1512-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29793503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29793503"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jonathan D Stallings, Edward G Tall, Srinivas Pentyala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Nuclear translocation of phospholipase C-delta1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5-bisphosphate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413813200"}], "href": "https://doi.org/10.1074/jbc.M413813200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15809301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15809301"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sophia Thore, Oleg Dyachok, Erik Gylfe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting beta-cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.02577"}], "href": "https://doi.org/10.1242/jcs.02577"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16159958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16159958"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yoshikazu Nakamura, Yoshio Hamada, Takashi Fujiwara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C-delta1 and -delta3 are essential in the trophoblast for placental development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.25.24.10979-10988.2005"}], "href": "https://doi.org/10.1128/MCB.25.24.10979-10988.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16314520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16314520"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Y Nakamura, K Kanemaru, R Kojima, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cddis.2014.181"}], "href": "https://doi.org/10.1038/cddis.2014.181"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24810051"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24810051"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Meng Zhu, Chuen Yan Leung, Marta N Shahbazi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00977-8"}], "href": "https://doi.org/10.1038/s41467-017-00977-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29030553"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29030553"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jin Young Kim, Hongtae Kim, Seok Geun Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2003.09.100"}], "href": "https://doi.org/10.1016/j.bbrc.2003.09.100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14550290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14550290"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sang Bong Lee, Péter Várnai, Andras Balla, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pleckstrin homology domain of phosphoinositide-specific phospholipase Cdelta4 is not a critical determinant of the membrane localization of the enzyme."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M312772200"}], "href": "https://doi.org/10.1074/jbc.M312772200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15037625"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15037625"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Na Young Kim, Sang Jung Ahn, Moo-Sang Kim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLC-δ1-Lf, a novel N-terminal extended phospholipase C-δ1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2013.07.022"}], "href": "https://doi.org/10.1016/j.gene.2013.07.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23892088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23892088"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Masayuki Hirata, Mutsumi Suzuki, Rika Ishii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic defect in phospholipase Cδ1 protects mice from obesity by regulating thermogenesis and adipogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db10-1500"}], "href": "https://doi.org/10.2337/db10-1500"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21617180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21617180"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kim A Staats, Lawrence Van Helleputte, Ashley R Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Dis (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.nbd.2013.08.006"}], "href": "https://doi.org/10.1016/j.nbd.2013.08.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23969236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23969236"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Kohya Kudo, Takafumi Uchida, Mayu Sawada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phospholipase C δ1 in macrophages negatively regulates TLR4-induced proinflammatory cytokine production and Fcγ receptor-mediated phagocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Biol Regul (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbior.2015.11.004"}], "href": "https://doi.org/10.1016/j.jbior.2015.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26643908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26643908"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Dan Hu, Zheng Jiang "}, {"type": "b", "children": [{"type": "t", "text": "[Phospholipase C δ1 (PLCD1) inhibits the proliferation, invasion and migration of CAPAN-1 and BXPC-3 pancreatic cancer cells]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi (2016)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27371838"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27371838"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Dhananjay P Thakur, Qiaochu Wang, Jaepyo Jeon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " -dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1113/JP279658"}], "href": "https://doi.org/10.1113/JP279658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32338378"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32338378"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sung Jin Park, Kirk D Haan, Yoshikazu Nakamura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PLCδ1 Plays Central Roles in the Osmotic Activation of ΔN-TRPV1 Channels in Mouse Supraoptic Neurons and in Murine Osmoregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2892-20.2021"}], "href": "https://doi.org/10.1523/JNEUROSCI.2892-20.2021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33707294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33707294"}]}]}]}
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| Proteins | ZN439_HUMAN |
| NCBI Gene ID | 90594 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF439 has 2,339 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 70 datasets.
Click the + buttons to view associations for ZNF439 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Achilles Cell Line Gene Essentiality Profiles | cell lines with fitness changed by ZNF439 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset. | |
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF439 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF439 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF439 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF439 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF439 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ZNF439 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF439 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ZNF439 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF439 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF439 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF439 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF439 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZNF439 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF439 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF439 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF439 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZNF439 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZNF439 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF439 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF439 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZNF439 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF439 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ZNF439 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF439 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF439 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ZNF439 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF439 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF439 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ZNF439 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF439 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF439 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with ZNF439 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF439 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF439 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF439 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZNF439 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for ZNF439 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF439 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF439 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF439 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF439 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF439 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF439 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZNF439 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ZNF439 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF439 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving ZNF439 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving ZNF439 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ZNF439 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF439 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF439 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ZNF439 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF439 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF439 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ZNF439 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of ZNF439 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ZNF439 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZNF439 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF439 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF439 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF439 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF439 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF439 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
