| HGNC Family | Zinc fingers |
| Name | zinc finger protein 442 |
| Description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Mar 2025] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nA careful review of the provided abstracts reveals no mention or characterization of ZNF442. Instead, the studies exclusively focus on vascular endothelial protein tyrosine phosphatase (VE‐PTP) and its critical role in maintaining endothelial cell junction integrity, regulating tyrosine phosphorylation of key adhesion molecules, and modulating vascular permeability and remodeling. These articles demonstrate that VE‐PTP interacts with proteins such as VE‐cadherin and the receptor Tie2 to influence endothelial barrier function and angiogenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nSeveral of these reports delineate the molecular mechanisms by which VE‐PTP modulates endothelial signaling. In particular, they show that VE‐PTP’s association with VE‐cadherin and Tie2 regulates key downstream pathways—including those involving Src family kinases, Rap1/Rac1, and other effectors—to sustain endothelial junction cohesion, control leukocyte transmigration, and influence neovascularization. This intricate regulation is central to both normal vascular development and the endothelial response to inflammatory or angiogenic stimuli."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAdditional investigations highlighted in these abstracts underscore the therapeutic potential of targeting VE‐PTP in various vascular disorders—including diabetic nephropathy, ocular neovascular diseases, atherosclerosis, and glaucoma—by stabilizing endothelial function and reducing pathological vessel leakage. In summary, while the collective literature provides detailed insights into VE‐PTP signaling and its vascular functions, none of the presented abstracts address or elucidate any biological role for ZNF442."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Roman Nawroth, Gregor Poell, Alexander Ranft, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/emboj/cdf497"}], "href": "https://doi.org/10.1093/emboj/cdf497"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12234928"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12234928"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Sebastian Bäumer, Linda Keller, Astrid Holtmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2006-01-0141"}], "href": "https://doi.org/10.1182/blood-2006-01-0141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16514057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16514057"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melissa G Dominguez, Virginia C Hughes, Li Pan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0611510104"}], "href": "https://doi.org/10.1073/pnas.0611510104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17360632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17360632"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroki Ishiguro, Jian-Ping Gong, F Scott Hall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of PTPRB gene polymorphism with drug addiction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet B Neuropsychiatr Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.b.30742"}], "href": "https://doi.org/10.1002/ajmg.b.30742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18361428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18361428"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Astrid F Nottebaum, Giuseppe Cagna, Mark Winderlich, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20080406"}], "href": "https://doi.org/10.1084/jem.20080406"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19015309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19015309"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mark Winderlich, Linda Keller, Giuseppe Cagna, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-PTP controls blood vessel development by balancing Tie-2 activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200811159"}], "href": "https://doi.org/10.1083/jcb.200811159"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19451274"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19451274"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Munemasa Mori, Yoji Murata, Takenori Kotani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22122"}], "href": "https://doi.org/10.1002/jcp.22122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20301196"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20301196"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Xinchun Shen, Gang Xi, Laura A Maile, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insulin-like growth factor (IGF) binding protein 2 functions coordinately with receptor protein tyrosine phosphatase β and the IGF-I receptor to regulate IGF-I-stimulated signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.01011-12"}], "href": "https://doi.org/10.1128/MCB.01011-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22869525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22869525"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Makoto Hayashi, Arindam Majumdar, Xiujuan Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms2683"}], "href": "https://doi.org/10.1038/ncomms2683"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23575676"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23575676"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Matthias Vockel, Dietmar Vestweber "}, {"type": "b", "children": [{"type": "t", "text": "How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-04-499228"}], "href": "https://doi.org/10.1182/blood-2013-04-499228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23908467"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23908467"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jikui Shen, Maike Frye, Bonnie L Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI74527"}], "href": "https://doi.org/10.1172/JCI74527"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25180601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25180601"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Shohei Yaji, Hiroshi Manya, Naoki Nakagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPβ."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwu118"}], "href": "https://doi.org/10.1093/glycob/cwu118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25361541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25361541"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Maike Frye, Martina Dierkes, Verena Küppers, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20150718"}], "href": "https://doi.org/10.1084/jem.20150718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26642851"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26642851"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dheeraj Soni, Sushil C Regmi, Dong-Mei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "2+"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " entry regulates disassembly of adherens junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00008.2017"}], "href": "https://doi.org/10.1152/ajplung.00008.2017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28385807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28385807"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Kelly J Soady, Giusy Tornillo, Howard Kendrick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Development (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/dev.149120"}], "href": "https://doi.org/10.1242/dev.149120"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28870991"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28870991"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Tomokazu Souma, Benjamin R Thomson, Stefan Heinen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1714446115"}], "href": "https://doi.org/10.1073/pnas.1714446115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29358379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29358379"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Isabel A Carota, Yael Kenig-Kozlovsky, Tuncer Onay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting VE-PTP phosphatase protects the kidney from diabetic injury."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20180009"}], "href": "https://doi.org/10.1084/jem.20180009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30886059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30886059"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Benjamin R Thomson, Isabel A Carota, Tomokazu Souma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.48474"}], "href": "https://doi.org/10.7554/eLife.48474"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31621585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31621585"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Francisco Llavero Bernal, Miriam Luque Montoro, Alazne Arrazola Sastre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Tyrosine Phosphatase hPTPRβ Controls the Early Signals and Dopaminergic Cells Viability via the P2X"}, {"type": "a", "children": [{"type": "t", "text": "sub"}], "href": "sub"}, {"type": "t", "text": "7"}, {"type": "a", "children": [{"type": "t", "text": "/sub"}], "href": "/sub"}, {"type": "t", "text": " Receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms222312936"}], "href": "https://doi.org/10.3390/ijms222312936"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34884741"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34884741"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Keisuke Shirakura, Peter Baluk, Astrid F Nottebaum, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Shear stress control of vascular leaks and atheromas through Tie2 activation by VE-PTP sequestration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Mol Med (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/emmm.202216128"}], "href": "https://doi.org/10.15252/emmm.202216128"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36740996"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36740996"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Peter Baluk, Keisuke Shirakura, Dietmar Vestweber, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heterogeneity of endothelial VE-PTP downstream polarization, Tie2 activation, junctional claudin-5, and permeability in the aorta and vena cava."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Tissue Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00441-023-03844-9"}], "href": "https://doi.org/10.1007/s00441-023-03844-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38032480"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38032480"}]}]}]}
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| Proteins | ZN442_HUMAN |
| NCBI Gene ID | 79973 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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ZNF442 has 4,144 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets.
Click the + buttons to view associations for ZNF442 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF442 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of ZNF442 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF442 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF442 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of ZNF442 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF442 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF442 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of ZNF442 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of ZNF442 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of ZNF442 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF442 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing ZNF442 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with ZNF442 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF442 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with ZNF442 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with ZNF442 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by ZNF442 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with ZNF442 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with ZNF442 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF442 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of ZNF442 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of ZNF442 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing ZNF442 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing ZNF442 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF442 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of ZNF442 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of ZNF442 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF442 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of ZNF442 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving ZNF442 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving ZNF442 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving ZNF442 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing ZNF442 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing ZNF442 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing ZNF442 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by ZNF442 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by ZNF442 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by ZNF442 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of ZNF442 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of ZNF442 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of ZNF442 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of ZNF442 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for ZNF442 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of ZNF442 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of ZNF442 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of ZNF442 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of ZNF442 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of ZNF442 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of ZNF442 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain ZNF442 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting ZNF442 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of ZNF442 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for ZNF442 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of ZNF442 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Reactome Pathways 2014 | pathways involving ZNF442 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving ZNF442 protein from the Reactome Pathways 2024 dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of ZNF442 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of ZNF442 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at ZNF442 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of ZNF442 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of ZNF442 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of ZNF442 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of ZNF442 gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of ZNF442 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of ZNF442 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of ZNF442 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF442 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of ZNF442 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with ZNF442 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
